The influence of antioxidant vitamin E on immunocompetence and oxidative stress of healthy Hong Kong individuals

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.

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Role of vitamin E and oxidative stress in exercise

Nutrition ◽

10.1016/s0899-9007(01)00639-6 ◽

2001 ◽

Vol 17 (10) ◽

pp. 809-814 ◽

Cited By ~ 75

Author(s):

Jennifer M. Sacheck ◽

Jeffrey B. Blumberg

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

And Oxidative Stress

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Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons

Medicina ◽

10.3390/medicina44050051 ◽

2008 ◽

Vol 44 (5) ◽

pp. 392 ◽

Cited By ~ 2

Author(s):

Liucija Černiauskienė ◽

Dalia Lukšienė ◽

Abdonas Tamošiūnas ◽

Regina Rėklaitienė ◽

Lilija Margevičienė

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Heart Disease ◽

Vitamin E ◽

Ischemic Heart Disease ◽

Odds Ratio ◽

Ischemic Heart ◽

Middle Aged ◽

Men And Women ◽

And Oxidative Stress

The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45–64 years). Material and methods. In this study, we have used data of 533 persons (247 men and 286 women) aged 45– 64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001–2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (≥5 mmol/L) and decreased level of lipid-standardized vitamin E (<20 mmol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods. Results. Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age. Conclusion. Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45–64-year-old persons.

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Vitamin E requirement in relation to dietary fish oil and oxidative stress in elderly

Free Radicals and Aging ◽

10.1007/978-3-0348-7460-1_39 ◽

1992 ◽

pp. 411-418 ◽

Cited By ~ 1

Author(s):

Mohsen Meydani

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Fish Oil ◽

Dietary Fish ◽

And Oxidative Stress

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The Silybin-Phospholipids-Vitamin E Complex Protects Against Fatty Degeneration, Nitrosative and Oxidative Stress in Rat Models of Liver Steatosis

Gastroenterology ◽

10.1016/s0016-5085(11)64084-5 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-985

Author(s):

Ignazio Grattagliano ◽

Catia V. Diogo ◽

Domenico Ferri ◽

David Q. Wang ◽

Piero Portincasa

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Liver Steatosis ◽

Fatty Degeneration ◽

Rat Models ◽

And Oxidative Stress

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Role of Anti-oxidants in the Treatment of Vitiligo

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v17i1.23132 ◽

2019 ◽

Vol 17 (1) ◽

pp. 49-57

Author(s):

Amit Kumar ◽

Sudha Agrawal ◽

Tapan Kumar Dhali ◽

Shankar Kumr Majhi

Keyword(s):

Oxidative Stress ◽

Placebo Group ◽

Vitamin E ◽

Primary Outcome ◽

Antioxidant Supplementation ◽

Significant Difference ◽

Anti Oxidant ◽

And Oxidative Stress

Introduction: The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies. Antioxidant supplementation has been reported to be useful in the treatment of vitiligo. Objective: To evaluate the role of oral antioxidants supplementation therapy in the treatment of vitiligo by assessing the onset of repigmentation and oxidative stress. Materials and Methods: A total of 80 cases of vitiligo randomized into two groups: antioxidant and placebo comprising 40 patients each and were followed up for 8 weeks for the assessment of onset of repigmentation of vitiliginous lesions as primary outcome. The activities of Malondialdehyde (MDA), Vitamin C, and Vitamin E in serum and of Catalase (CAT) in erythrocytes of patients at baseline and at end of eight weeks were also assessed by using the spectrophotometric assay. Results: The onset of repigmentation was noted significantly earlier among the anti-oxidant group as compared to the placebo group (p=0.015). At the baseline, between the two groups, no significant difference was found in the different biochemical parameters. However, at the end of 2 months the level of MDA (p<0.001) was found to be significantly lower and that of Vitamin E (p<0.001) and CAT (p=0.005) was significantly higher among the anti-oxidants group as compared to the placebo group. Conclusion: Antioxidant supplementation carried a better response in terms of early onset of repigmentation and significant decrease in the oxidative stress, in the short follow up of two months.

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