DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF RAMOSETRON HYDROCHLORIDE IN BULK AND TABLETS
Keyword(s):
Rp Hplc
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A RP-HPLC method was developed and validated for the determination of ramosetron hydrochloride in pharmaceutical formulation as per ICH and FDA guidelines. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (95:5) in an isocratic mode. The flow rate is 0.8 mL/min and the detection was done at 302 nm. The linearity range was observed in the range of 1-6 mcg/mL. The accuracy of the method was found to be 99.0 to 99.5% and %RSD was found to be less than 2% indicating high degree of accuracy and precision for the proposed HPLC method. Limit of detection and limit of quantification of the method were found to be 0.028 and 0.0851 mcg/mL respectively.
2016 ◽
Vol 10
(1)
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pp. 33-43
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Keyword(s):
2014 ◽
Vol 50
(4)
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pp. 793-797
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2018 ◽
Vol 13
(1)
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pp. 36-44
2020 ◽
Vol 10
(6)
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pp. 49-56
2018 ◽
Vol 3
(2)
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pp. 14-18