scholarly journals Sexual Dimorphism in Hematocrit Response Following Red Blood Cell Transfusion of Critically Ill Surgical Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Fredric M. Pieracci ◽  
Carlton C. Barnett ◽  
Nicole Townsend ◽  
Ernest E. Moore ◽  
Jeffery Johnson ◽  
...  
Keyword(s):  
Immune Response ◽  
Sexual Dimorphism ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Red Blood Cell Transfusion ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
The Relationship

The change in hematocrit (ΔHct) following packed red blood cell (pRBCs) transfusion is a clinically relevant measurement of transfusion efficacy that is influenced by post-transfusion hemolysis. Sexual dimorphism has been observed in critical illness and may be related to gender-specific differences in immune response. We investigated the relationship between both donor and recipient gender and ΔHct in an analysis of all pRBCs transfusions in our surgical intensive care unit (2006–2009). The relationship between both donor and recipient gender and ΔHct (% points) was assessed using both univariate and multivariable analysis. A total of 575 units of pRBCs were given to 342 patients; 289 (49.9%) donors were male. By univariate analysis, ΔHct was significantly greater for female as compared to male recipients (3.81% versus 2.82%, resp., ). No association was observed between donor gender and ΔHct, which was 3.02% following receipt of female blood versus 3.23% following receipt of male blood (). By multivariable analysis, recipient gender remained associated significantly with ΔHct (). In conclusion, recipient gender is independently associated with ΔHct following pRBCs transfusion. This association does not appear related to either demographic or anthropomorphic factors, raising the possibility of gender-related differences in recipient immune response to transfusion.

Immune Response to Chronic Red Blood Cell Transfusion

Vox Sanguinis ◽  
1983 ◽  
Vol 44 (4) ◽  
pp. 212-217 ◽  
Author(s):  
Neil Blumberg ◽  
Kathy Peck ◽  
Karen Ross ◽  
Eduardo Avila
Keyword(s):  
Immune Response ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion

scholarly journals Risk factors of necrotizing enterocolitis in neonates with sepsis: A retrospective case-control study

2020 ◽  
Vol 34 ◽  
pp. 205873842096381
Author(s):  
Zheng-Li Wang ◽  
Yao An ◽  
Yu He ◽  
Xiao-Yu Hu ◽  
Lu Guo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Blood Cell ◽  
Necrotizing Enterocolitis ◽  
Red Blood Cell ◽  
Late Onset ◽  
Univariate Analysis ◽  
Red Blood Cell Transfusion ◽  
Control Group ◽  
Retrospective Case

Sepsis, a severe infectious disease in the neonatal period, is considered a risk factor for necrotizing enterocolitis (NEC). To investigate the specific risk factors for NEC in septic infants, septic infants admitted to our center from January 2010 to April 2018 were included. Septic neonates with proven NEC (Bell’s stage ⩾II) were enrolled in the NEC group, and those without NEC were enrolled in the control group. Demographics, clinical characteristics, and risk factors were compared between the two groups. Univariate and logistic regression analyses were used to evaluate the potential risk factors for NEC. A total of 610 septic neonates were included, of whom 78 (12.8%) had complicated NEC. The univariate analysis indicated that infants with NEC had a lower birth weight, a lower gestational age, and older age on admission than those without NEC ( P < 0.05). Higher rates of anemia, prolonged rupture of membranes (PROM) (⩾18 h), pregnancy-induced hypertension, late-onset sepsis (LOS), red blood cell transfusion and hypoalbuminemia were observed in the NEC group than in the non-NEC group (P<0.05). Logistic regression analysis revealed LOS ( P = 0.000), red blood cell transfusion ( P = 0.001) and hypoalbuminemia ( P = 0.001) were associated with the development of NEC. Among NEC infants, those who needed red blood cell transfusion had a longer hospitalization duration than those who did not need transfusion ( P < 0.05). LOS, red blood cell transfusion and hypoalbuminemia were independent risk factors for the development of NEC in infants with sepsis. Taking measures to reduce the occurrence of hypoproteinemia and severe anemia may help to reduce the occurrence of NEC in septic neonates.

Packed Red Blood Cell Transfusion and Decreased Mortality in Intracerebral Hemorrhage

Neurosurgery ◽  
2011 ◽  
Vol 68 (5) ◽  
pp. 1286-1292 ◽  
Author(s):  
Kevin N. Sheth ◽  
Aaron J. Gilson ◽  
Yuchiao Chang ◽  
Mona A. Kumar ◽  
Rosanna M. Rahman ◽  
...  
Keyword(s):  
Blood Cell ◽  
Intracerebral Hemorrhage ◽  
Red Blood Cell ◽  
Odds Ratio ◽  
Multivariable Analysis ◽  
Red Blood Cell Transfusion ◽  
Do Not Resuscitate ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen ◽  
Improved Outcome

Abstract BACKGROUND: Accumulating data suggest that anemia worsens outcomes in critically ill patients, including those with subarachnoid and intracerebral hemorrhage (ICH). Although packed red blood cell (PRBC) transfusion appears to increase brain tissue oxygen, it is unknown whether such transfusions, which are commonly administered in patients with intracranial hemorrhage, alter outcome. OBJECTIVE: Following up on our observation that anemia is associated with poor outcome in patients with ICH, we investigated whether PRBC transfusion was associated with any benefit. METHODS: Five hundred forty-six consecutive subjects were identified from an ongoing single-center, prospective cohort study of nontraumatic ICH over a 6-year period. Clinical and radiographic characteristics, laboratory values including admission and daily mean hemoglobin values, and all instances of PRBC transfusion were recorded. Aggressiveness of care was assessed by whether the patient had a “do not resuscitate” order activated during hospitalization. The primary endpoint was 30-day survival. RESULTS: Anemia was present in 144 of 546 patients (26%) on admission and developed subsequently in an additional 250, leaving just 152 of 546 patients (28%) who never developed anemia. PRBC transfusion was administered to 100 patients (18%) during their hospital stay, 98% of whom were anemic. In multivariable analysis, PRBC transfusion was associated with improved survival at 30 days (odds ratio: 2.76; 95% confidence interval: 1.45-5.26; P = .002). CONCLUSION: Anemia develops in the majority of patients with ICH at some point during their hospitalization. PRBC transfusion was associated with improved outcome in these patients.

Influence of Red Blood Cell Transfusion on CD4+ T-Helper Cells Immune Response in Patients Undergoing Cardiac Surgery

2010 ◽  
Vol 164 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Santiago R. Leal-Noval ◽  
Manuel Muñoz-Gómez ◽  
Victoria Arellano ◽  
Alejandro Adsuar ◽  
Mercedes Jiménez-Sánchez ◽  
...  
Keyword(s):  
Immune Response ◽  
Cardiac Surgery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
T Helper Cells ◽  
Red Blood Cell Transfusion ◽  
T Helper ◽  
Helper Cells

Red Blood Cell Transfusion and its Relationship with Pedicle Thrombosis in Microvascular Free Flaps

2021 ◽  
Author(s):  
Carlos Eduardo Torres Fuentes ◽  
Iván Enrique Rodríguez Mantilla ◽  
Diego Nicolás Guerrero Cáceres ◽  
Diego Felipe Camargo Gonzalez
Keyword(s):  
Blood Cell ◽  
Free Flap ◽  
Red Blood Cell ◽  
Cox Regression ◽  
Free Flaps ◽  
Perioperative Period ◽  
Red Blood Cell Transfusion ◽  
Flap Survival ◽  
Increased Risk ◽  
The Relationship

Abstract Background Free flaps have become a highly valuable tool for complex reconstructive surgeries. The requirement of red blood cell transfusion (RBCT) during the perioperative period is common and its effect on the free flap survival is debatable. The aim of this study was to determine the relationship between perioperative RBCT and vascular pedicle thrombosis (VPT). Methods For this study 302 free flaps performed between January 2006 and December 2019 were retrospectively analyzed. It included their characteristics from before, during, and after the surgical procedure. The incidence of VPT and flap survival were calculated based on Kaplan Meier's method and the relationship between VPT and perioperative variables were analyzed by Cox regression models. Results The transfusion group was represented by 62 flaps (20.5%) and no transfusion by 240 flaps. The overall transfusion requirement was 20.5% and the cumulative incidence of VPT was 9.11%. A statistically significant relationship was not demonstrated between flap survival and transfusion status (HR = 1.73 IC 95%: 0.5 to 3.96; p = 0.192) (p = 0.192) independently from the number of units transfused, the preoperative diagnosis of anemia, and the type of flap used and did not establish an increased risk of VPT. Conclusions This study did not demonstrate an association between RBCT during preoperative period and the risk for VPT or microvascular free flap survival rate on postoperative follow up.

The relationship of red blood cell transfusion to intestinal mucosal injury in premature infants

2017 ◽  
Vol 52 (7) ◽  
pp. 1152-1155 ◽  
Author(s):  
Nhan Hyung ◽  
Insiyah Campwala ◽  
Danilo S. Boskovic ◽  
Laurel Slater ◽  
Yayesh Asmerom ◽  
...  
Keyword(s):  
Blood Cell ◽  
Premature Infants ◽  
Red Blood Cell ◽  
Mucosal Injury ◽  
Red Blood Cell Transfusion ◽  
Intestinal Mucosal Injury ◽  
Relationship Of ◽  
The Relationship

scholarly journals Red blood cell transfusion practices in two surgical intensive care units: a mixed methods assessment of barriers to evidence-based practice

Transfusion ◽  
2014 ◽  
Vol 54 (10pt2) ◽  
pp. 2658-2667 ◽  
Author(s):  
David J. Murphy ◽  
Peter J. Pronovost ◽  
Christoph U. Lehmann ◽  
Ayse P. Gurses ◽  
Glenn J.R. Whitman ◽  
...  
Keyword(s):  
Intensive Care ◽  
Mixed Methods ◽  
Blood Cell ◽  
Intensive Care Units ◽  
Red Blood Cell ◽  
Evidence Based Practice ◽  
Red Blood Cell Transfusion ◽  
Evidence Based ◽  
Surgical Intensive Care
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