Urinary Bisphenol A Levels and Measures of Obesity: Results from the National Health and Nutrition Examination Survey 2003–2008

Bisphenol A (BPA) is a widely used chemical. We examined the association between urinary BPA levels and obesity in the National Health and Nutritional Examination Survey (NHANES) 2003–2008. The main outcome of interest was obesity defined as (1) body mass index (BMI) ≥ 30 Kg/m2 and (2) waist circumference (WC) ≥ 102 cm in men and ≥ 88 cm in women. Urinary BPA levels were examined in quartiles. Overall, we observed a positive association between increasing levels of urinary BPA and both measures of obesity, independent of potential confounding factors including, smoking, alcohol consumption, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) associated with quartile 4 for BMI-based obesity was 1.69 (1.30–2.20); P-trend < 0.0001 and for WC-based obesity was 1.59 (1.21–2.09); P-trend = 0.0009. This association between BPA and both measures of obesity was consistently present across gender and race-ethnic groups (all P-trend < 0.05). Elevated levels of urinary BPA are associated with measures of obesity independent of traditional risk factors. This association is consistently present across gender and race-ethnic groups. Future prospective studies are needed to confirm or disprove this finding.

Download Full-text

Bisphenol A and Metabolic Syndrome: Results from NHANES

International Journal of Endocrinology ◽

10.1155/2012/598180 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 54

Author(s):

Srinivas Teppala ◽

Suresh Madhavan ◽

Anoop Shankar

Keyword(s):

Metabolic Syndrome ◽

Bisphenol A ◽

Odds Ratio ◽

Alcohol Intake ◽

Adjusted Odds Ratio ◽

Population Based ◽

Health And Nutrition ◽

Direct Association ◽

Race Ethnicity ◽

Traditional Risk Factors

Background. Bisphenol A (BPA) is detected in the urine of>95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS.Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003–2008. The main outcome was the presence of MetS (n=741).Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the multivariable adjusted odds ratio (95% confidence interval) of MetS in tertile 3 was 1.51 (1.07–2.12);P-trend was 0.02.Conclusions. Urinary BPA levels are positively associated with MetS, in a representative sample of US adults and independent of traditional risk factors for MetS. Future, prospective studies are needed to confirm our findings.

Download Full-text

Urinary Bisphenol A and Hypertension in a Multiethnic Sample of US Adults

Journal of Environmental and Public Health ◽

10.1155/2012/481641 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 77

Author(s):

Anoop Shankar ◽

Srinivas Teppala

Keyword(s):

Diabetes Mellitus ◽

Bisphenol A ◽

Animal Studies ◽

Smoking Status ◽

Human Study ◽

Positive Association ◽

Total Serum ◽

Total Serum Cholesterol ◽

Race Ethnicity ◽

Traditional Risk Factors

Background. Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, with >93% of US adults having detectable BPA levels in urine. Recent animal studies have suggested that BPA exposure may have a role in several mechanisms involved in the development of hypertension, including weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress. However, no previous human study has examined the association between markers of BPA exposure and hypertension.Methods. We examined urinary BPA levels in 1380 subjects from the National Health and Nutritional Examination Survey 2003-2004. Main outcome-of-interest was hypertension, defined as blood pressure-reducing medication use and/or blood pressures >140/90 mm of Hg (n=580).Results. We observed a positive association between increasing levels of urinary BPA and hypertension independent of confounding factors such as age, gender, race/ethnicity, smoking, body mass index (BMI), diabetes mellitus and total serum cholesterol levels. Compared to tertile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of hypertension associated with tertile 3 was 1.50 (1.12−2.00);P-trend = 0.007. The association was consistently present in subgroup analyses by race/ethnicity, smoking status, BMI, and diabetes mellitus.Conclusions. Urinary BPA levels are associated with hypertension, independent of traditional risk factors.

Download Full-text

Hemoglobin and Hematocrit Levels are Positively Associated with Blood Pressure in Children and Adolescents Aged 10 to 18 Years: The Korea National Health and Nutrition Examination Surveys 2007–2017.

10.21203/rs.3.rs-154577/v1 ◽

2021 ◽

Author(s):

Hwal Rim Jeong ◽

Hae Sang Lee ◽

Young Seok Shim ◽

Jin Soon Hwang

Keyword(s):

Blood Pressure ◽

Children And Adolescents ◽

National Health ◽

Household Income ◽

Positive Association ◽

Children And Adolescent ◽

Health And Nutrition ◽

Prevalence Of Obesity ◽

Study Population ◽

Hb Concentration

Abstract Objective: To investigate investigated the association of hemoglobin (Hb) concentration, hematocrit (Hct) and blood pressure (BP) in children and adolescents.Methods: The study population consisted of a total 7,950 subjects (4,229 boys, 3,721 girls) aged 10 to 18 years who participated in the Korea National Health and Nutrition Examination Surveys conducted between 2007 and 2017.Results: The prevalence of hypertension is estimated about 19.19% (21.51% for boys and 16.5% for girls). The prevalence of obesity is estimated about 9.59% (10.5% for boys and 8.6% for girls). Hb and Hct level tended to increase with the degree of obesity and blood pressure. The systolic BP (SBP) and diastolic BP (DBP) have positively correlated with Hb and Hct levels in both sex. In the multiple regression analysis, the Hb and Hct presented positive association with SBP and DBP after adjustment for for age, BMI SDS, alcohol consumption, smoking physical activity, rural residence, household income, diagnosis of T2DM, hypertension, and dyslipidemia.Conclusion: Hemoglobin and hematocrit levels were positively associated with SBP and DBP, in children and adolescent, aged 10- 18 year.

Download Full-text

The role of traditional risk factors in explaining the social disparities in cardiovascular death: The national health and Nutrition Examination Survey III (NHANES III)

American Journal of Preventive Cardiology ◽

10.1016/j.ajpc.2020.100094 ◽

2020 ◽

Vol 4 ◽

pp. 100094

Author(s):

Wei Zhang ◽

Muhammad Imtiaz Ahmad ◽

Elsayed Z. Soliman

Keyword(s):

Risk Factors ◽

National Health ◽

Cardiovascular Death ◽

Nhanes Iii ◽

Social Disparities ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

The Social ◽

Traditional Risk Factors

Download Full-text

Associations between Macronutrient Intakes and Obesity/Metabolic Risk Phenotypes: Findings of the Korean National Health and Nutrition Examination Survey

Nutrients ◽

10.3390/nu11030628 ◽

2019 ◽

Vol 11 (3) ◽

pp. 628 ◽

Cited By ~ 5

Author(s):

Ha-Na Kim ◽

Sang-Wook Song

Keyword(s):

National Health ◽

Smoking Status ◽

Positive Association ◽

Normal Weight ◽

Metabolic Risk ◽

Metabolic Abnormalities ◽

Nutrition Examination Survey ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Health And Nutrition

Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. We used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted in 2014 and 2016, and data on a total of 7374 participants were analyzed. Macronutrient intakes were defined as the proportions of energy derived from carbohydrate, protein, and fat. Those exhibiting obesity/metabolic risk phenotypes (or not) were divided into four groups: normal weight without metabolic abnormalities; obese without metabolic abnormalities; normal weight with metabolic abnormalities; and obese with metabolic abnormalities. After adjusting for age, smoking status, alcohol consumption, extent of physical activity, household income, and daily fiber intake, no association was found between the proportions of carbohydrate, protein, or fat intakes and obesity/metabolic risk phenotypes except for a positive association between metabolically healthy but obese status and low protein intake in females. Further studies are required to evaluate the effects of macronutrient intakes on obesity/metabolic risk phenotypes and associated health outcomes.

Download Full-text

Association of Urinary Bisphenol A Concentration with Allergic Asthma: Results from the National Health and Nutrition Examination Survey 2005–2006

Journal of Asthma ◽

10.3109/02770903.2012.721041 ◽

2012 ◽

Vol 49 (8) ◽

pp. 800-806 ◽

Cited By ~ 40

Author(s):

Swapnil V. Vaidya ◽

Hemant Kulkarni

Keyword(s):

Bisphenol A ◽

Allergic Asthma ◽

National Health ◽

Nutrition Examination Survey ◽

Health And Nutrition

Download Full-text

Declining serum total cholesterol levels among US adults. The National Health and Nutrition Examination Surveys

JAMA ◽

10.1001/jama.269.23.3002 ◽

1993 ◽

Vol 269 (23) ◽

pp. 3002-3008 ◽

Cited By ~ 81

Author(s):

C. L. Johnson

Keyword(s):

Total Cholesterol ◽

National Health ◽

Serum Total Cholesterol ◽

Health And Nutrition ◽

Cholesterol Levels

Download Full-text

Relationship between Egg Consumption and Body Composition as Well as Serum Cholesterol Level: Korea National Health and Nutrition Examination Survey 2008–2011

Journal of Clinical Medicine ◽

10.3390/jcm10245918 ◽

2021 ◽

Vol 10 (24) ◽

pp. 5918

Author(s):

Jung-Eun Shim ◽

Young-Gyun Seo

Keyword(s):

Body Composition ◽

Serum Cholesterol ◽

National Health ◽

Health Benefit ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Percentage Body Fat ◽

Egg Consumption ◽

Health And Nutrition ◽

Cholesterol Levels

We analyzed the relationship between egg consumption, body composition, and serum cholesterol levels. We obtained data on egg consumption by using a food frequency questionnaire (FFQ) (13,132 adults) and the 24-h dietary recall (24HR) (13,366 adults) from the fourth and fifth Korea National Health and Nutrition Examination Surveys (2008–2011). In men, consuming 2–3 eggs/week was associated with higher fat mass (FM), percentage body fat (PBF), and fat-to-muscle ratio (FtoM), compared to consuming <1 egg/week. In women, consuming 1–6 eggs/week was associated with higher low-density lipoprotein cholesterol, consuming 2–6 eggs/week was associated with higher total cholesterol, and consuming 4–6 eggs/week was associated with higher FM and high-density lipoprotein cholesterol, compared to consuming <1 egg/week. There was no relationship between egg consumption and the prevalence of dyslipidemia, and there was no relationship between egg consumption, body composition, and serum cholesterol levels according to the 24HR. However, there was some association with other cardiovascular diseases and consumption of certain amounts of eggs. Egg consumption investigated by FFQ was associated with body composition and serum cholesterol levels. However, the egg consumption investigated by the 24HR resulted in no health benefit or harm with respect to body composition and cholesterol.

Download Full-text