scholarly journals Associations between Macronutrient Intakes and Obesity/Metabolic Risk Phenotypes: Findings of the Korean National Health and Nutrition Examination Survey

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 628 ◽  
Author(s):  
Ha-Na Kim ◽  
Sang-Wook Song

Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. We used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted in 2014 and 2016, and data on a total of 7374 participants were analyzed. Macronutrient intakes were defined as the proportions of energy derived from carbohydrate, protein, and fat. Those exhibiting obesity/metabolic risk phenotypes (or not) were divided into four groups: normal weight without metabolic abnormalities; obese without metabolic abnormalities; normal weight with metabolic abnormalities; and obese with metabolic abnormalities. After adjusting for age, smoking status, alcohol consumption, extent of physical activity, household income, and daily fiber intake, no association was found between the proportions of carbohydrate, protein, or fat intakes and obesity/metabolic risk phenotypes except for a positive association between metabolically healthy but obese status and low protein intake in females. Further studies are required to evaluate the effects of macronutrient intakes on obesity/metabolic risk phenotypes and associated health outcomes.

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jeff A. Dennis ◽  
Lisaann S. Gittner ◽  
J. Drew Payne ◽  
Kenneth Nugent

Abstract Background Global 12-month psychosis prevalence is estimated at roughly 0.4%, although prevalence of antipsychotic use in the U.S. is estimated at roughly 1.7%. Antipsychotics are frequently prescribed for off label uses, but have also been shown to carry risk factors for certain comorbid conditions and with other prescription medications. The study aims to describe the socio-demographic and health characteristics of U.S. adults taking prescription antipsychotic medications, and to better understand the association of antipsychotic medications and comorbid chronic diseases. Methods The study pools 2013–2018 data from the National Health and Nutrition Examination Survey (NHANES), a nationally representative cross-sectional survey of non-institutionalized U.S. residents (n = 17,691). Survey staff record prescription medications taken within the past 30 days for each respondent, from which typical and atypical antipsychotic medications were identified. Results Prevalence of antipsychotic use among U.S. adults was 1.6% (n = 320). Over 90% of individuals taking antipsychotics reported having health insurance and a usual place for care, significantly more than their counterparts not taking antipsychotics. Further, those taking antipsychotics reported higher prevalence of comorbid chronic diseases and took an average of 2.3 prescription medications more than individuals not taking antipsychotics. Individuals taking antipsychotics were more likely to sleep 9 or more hours per night, be a current smoker, and have a body mass index greater than 30 kg/m2. Conclusions U.S. adults who take antipsychotic medications report more consistent health care access and higher prevalence of comorbid chronic diseases compared to those not taking antipsychotics. The higher comorbidity prevalence and number of total prescriptions highlight the need for careful assessment and monitoring of existing comorbidities and potential drug-drug interactions among adults taking antipsychotics in the U.S.


Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Heli Ghandehari ◽  
Sachin Kamal-Bahl ◽  
Nathan D Wong

Background: Recent U.S. population data are lacking regarding the achievement of recommended lipid levels according to demographic factors and comorbidities. We evaluated the extent of LDL-C, HDL-C, triglyceride, and overall lipid goal attainment in U.S. adults. Design, Setting, and Participants: Data analysis from adults aged ≥20 who had fasted for ≥8 hours (n=2987 representing 132.7 million) in the National Health and Nutrition Examination Survey 2003–2004, a representative cross-sectional survey of the non-institutionalized civilian U.S. population. Main Outcome Measures: The proportion of adults at recommended levels for LDL-C, HDL-C, triglycerides, and all lipids were examined by gender, age, ethnicity and the presence of cardiovascular disease (CVD), diabetes (DM) or metabolic syndrome (MetS). Goals were <100 mg/dl for LDL-C for DM, CVD, or 2+ risk factors and >20% 10-year risk for coronary heart disease (CHD), <130 mg/dl if 2+ risk factors and ≤20% 10-year risk for CHD, or <160 mg/dl if <2 risk factors; ≥40 mg/dl (male) or ≥50 mg/dl (female) for HDL-C; and <150 mg/dl for triglycerides. Results: The proportion at goal for LDL-C was 74.5%, HDL-C 73.2%, triglycerides 73.6%, and 47.5% for all lipids. Control of LDL-C and triglycerides was greater in females, and HDL-C greater in males. Mexican-Americans and persons with CVD, DM, or MetS were least likely to be at recommended levels (see Table ). Table . Proportion (%) of US adults 2003–2004 at recommended levels for LDL-C, HDL-C, triglycerides, and all lipids Conclusions: While three-fourths of U.S. adults are at recommended levels for LDL-C, HDL-C and triglycerides individually, less than half are at goal for all lipids. For persons with DM or CVD, only a third are at goal for LDL-C and only a sixth are at goal for all lipids. Improved treatment efforts to optimize goal attainment of all lipids are required.


Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1467 ◽  
Author(s):  
Sangah Shin ◽  
Seong-Ah Kim ◽  
Jinwoo Ha ◽  
Kyungjoon Lim

It is well known that the consumption of sugar-sweetened beverages (SSBs) increases the risk of developing obesity and metabolic syndrome (MetS). However, there are not many studies investigating the link between SSBs and increased incidences of diseases in the Asian population, and in particular, in Korea. We explored the association of SSB consumption with the risk of developing obesity and MetS among Korean adults (12,112 participants from the 2012–2016 Korean National Health and Nutrition Examination Survey). We calculated the total SSB consumption frequency by counting each beverage item, including soda beverages, fruit juices, and sweetened rice drinks. Obesity was defined as a body mass index ≥25 kg/m2, and MetS was defined using the National Cholesterol Education Program, Adult Treatment Panel III. A survey logistic regression analyses was conducted to examine the association of SSB consumption with obesity and MetS, adjusting for related confounders such as age, energy intake, household income, education, alcohol drinking, smoking status, and physical activity. The SSB consumption was positively associated with an increased risk of the prevalence for obesity (Odd ratio (OR): 1.60; 95% confidence interval (CI): 1.23–2.09; p for trend = 0.0009) and MetS (OR: 1.61; 95% CI: 1.20–2.16; p for trend = 0.0003) among women. In men, SSB consumption only contributed to a higher prevalence of obesity (OR: 1.38; 95% CI: 1.11–1.72; p for trend = 0.0041). In conclusion, increased consumption of SSBs was closely linked with a higher prevalence of obesity and MetS in the Korean population.


2021 ◽  
Author(s):  
Sunggun Lee ◽  
Min Wook So ◽  
Doo-Ho Lim ◽  
Mi-Young Kim ◽  
Jae-Ha Lee ◽  
...  

Abstract Objective As heritability of hyperuricemia remains largely unexplained, we analyzed the association between parental and offspring hyperuricemia at the phenotype level. Methods This cross-sectional study included data on 2373 offspring and both-parent pairs from the 7th Korean National Health and Nutrition Examination Survey. Logistic regression and generalized estimating equation analysis were used to evaluate the association between offspring and parental hyperuricemia adjusting for metabolic risk factors and alcohol intake. Results Both maternal and paternal hyperuricemia were associated with offspring hyperuricemia among teenagers, but from age of 20 years, a strong association was observed between offspring and paternal, rather than, maternal hyperuricemia, and this could not be explained by metabolic risk factors such as obesity. However, there was positive interaction between offspring alcohol intake and parental hyperuricemia, and there was a stronger association between terciles of offspring alcohol intake and hyperuricemia in the presence of parental hyperuricemia: T1 (reference), T2 OR 1.1 (0.3–4.6), and T3 OR 3.3 (1.4–7.9) (P for trend 0.017) vs. T1 (reference), T2 OR 0.7 (0.3–1.9), and T3 OR 1.1 (0.6–2.2) (P for trend 0.974). Conclusion These results suggest gene-environment interaction, especially with respect to alcohol intake for hyperuricemia in Korean adults.


1986 ◽  
Vol 65 (12) ◽  
pp. 1435-1440 ◽  
Author(s):  
A.I. Ismail

The purpose of this study was to investigate the association between the probability of having high DMFT scores and reported consumption of eight food groups. The sample included Americans (aged from 9 to 29 years) examined during the first National Health and Nutrition Examination Survey conducted between 1971 and 1974. Analysis was restricted to comparing those individuals having DMFT scores equal to or above the 80th percentile of the DMFT distribution with those having scores equal to or below the 20th percentile of the distribution. The strongest discriminator between the low- and high-DMFT groups was the between-meal consumption of table sugars and syrups. The between-meal consumption of sugary desserts was also significantly associated with high DMFT scores. Foods to which table sugars are usually added before consumption, such as coffee, chocolate, and tea drinks, were associated with high DMFT scores in the bivariate analysis. When the same-day consumption of table sugars and syrups was accounted for, the associations became nonsignificant. The reported consumption of breakfast cereals, bread, fruit juices, ice cream, and nuts and crackers was not associated with high DMFT scores, perhaps because they were consumed only infrequently.


Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1366
Author(s):  
Taehui Kim ◽  
Jiyoung Kim

This study aimed to provide basic data on the prevention of hepatitis C infection by identifying factors related to it based on the data from the National Health and Nutrition Examination Survey (KNHANES). The sixth (2013–2015) and seventh (2016–2018) Korean National Health and Nutrition Examination Surveys conducted by the Korean Disease Control and Prevention Agency were analyzed. This is a population-based, nationally representative, multistage, cross-sectional survey of noninstitutionalized persons in Korea. Multivariate regression analysis was used to assess the significance of the variables. A total of 32,942 persons aged >20 years were selected for this study. Among them, 282 tested positive for hepatitis C antibodies, while 32,660 tested negative. Of the 282 persons who tested positive, 48.6% were men and 51.4% were women. The factors associated with hepatitis C infection were age, education level, self-rated health status, and liver cirrhosis. Therefore, there is a need to educate people and implement preventive programs based on age and education levels to reduce the incidence of hepatitis C infections. In addition, it is necessary to include hepatitis C screening as part of the National Health Examination to diagnose hepatitis C infections.


Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 116
Author(s):  
Maaike van Gerwen ◽  
Naomi Alpert ◽  
Mathilda Alsen ◽  
Kimia Ziadkhanpour ◽  
Emanuela Taioli ◽  
...  

Perfluoroalkyl acids (PFAS) are known endocrine disrupting chemicals, potentially affecting thyroid function. Smoking has been associated with PFAS levels as well as with thyroid function. The impact of smoking on the association between PFAS and thyroid function remains to be elucidated, so the objective was to assess the effect of PFAS exposure on thyroid function in the general population, stratified by smoking status, using the National Health and Nutrition Examination Survey (NHANES). NHANES adult participants who were part of the 2011–2012 laboratory subsample and had PFAS and thyroid function measured were included (n = 1325). Adjusted linear regression models and stratified analyses were performed. There was a significant positive association between perfluorooctanesulfonic acid (PFOS) (p = 0.003), perfluorononanoic acid (PFNA) (p = 0.014), total PFAS (p = 0.004) concentrations and free T4 (FT4). No significant associations were found between perfluorooctanoic acid (PFOA), PFOS, perfluorohexane sulfonate (PFHxS), PFNA, total PFAS and total T4 (TT4) or thyroid stimulating hormone (TSH). In non-smokers, a significant positive association was found between PFOS (p = 0.003), PFHxS (p = 0.034), PFNA (p = 0.012), total PFAS (p = 0.003) and FT4 while no significant associations were found in smokers. The present study showed that increased PFAS exposure was associated with increased FT4 in non-smokers, while no association was found in smokers. These results confirm that smoking modifies the association between PFAS exposure and thyroid function.


Cardiology ◽  
2018 ◽  
Vol 141 (4) ◽  
pp. 177-182 ◽  
Author(s):  
Eric M. Hecht ◽  
Kristopher L. Arheart ◽  
David J. Lee ◽  
Charles H. Hennekens ◽  
WayWay M. Hlaing

The interrelationships between cadmium biomarker levels, smoking, and myocardial infarction and stroke have been established. In this cross-sectional analysis, we explored the interrelationships of blood cadmium levels, smoking, and angina. We analyzed the National Health and Nutrition Examination Survey (NHANES, 2003–2014) accounting for the multi-staged complex sampling design. Participants 40–79 years of age with blood cadmium levels but without a history of myocardial infarction and/or stroke were included (n = 14,832). We examined blood cadmium levels (3 tertile groups) in relation to 3 (diagnosed, undiagnosed, and composite diagnosed and/or undiagnosed) angina outcomes. Multivariable logistic regression models adjusted for age, diabetes, smoking status, and household income were used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Of 14,832 participants, 741 (4.2%) had positive composite angina. The crude and adjusted ORs comparing those in the lowest tertile (referent group) of blood cadmium to those in the highest tertile for the composite outcome were 1.82 (95% CI 1.42–2.34) and 1.45 (95% CI 1.12–1.88), respectively. These cross-sectional data from a nationally representative sample contribute to the hypothesis that there are interrelationships between smoking, cadmium, and angina.


2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Won Kyoung Cho ◽  
Hyo-Kyoung Nam ◽  
Jae Hyun Kim ◽  
Young-Jun Rhie ◽  
Sochung Chung ◽  
...  

Purpose. In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. Methods. Among 2679 subjects aged 10–19 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013–2015), 1067 adolescents (M=559, F=508) with available data on free T4 (FT4) and thyroid-stimulating hormone (TSH) were included. Study participants were classified into normal weight [body mass index (BMI) below 85th percentile, 80.7%], overweight (85th ≤ BMI< 95th percentile, 8.7%), and obesity (BMI ≥ 95th percentile, 10.6%). Results. With increasing levels of BMI category, the means of TSH increased (2.73 ± 0.06, 2.77 ± 0.02, and 3.24 ± 0.22 mIU/L, P=0.031) and FT4 decreased (1.30 ± 0.01, 1.26 ± 0.02, and 1.25 ± 0.02 ng/mL, P=0.001). Positive linear associations were observed between TSH and BMI z-score (P=0.031), waist circumference (P=0.013), waist-height ratio (P=0.002), systolic blood pressure (P=0.001), total cholesterol (P=0.008), and triglyceride (P=0.002) after adjusting for age and sex. With per-unit increase in TSH, the odds ratios of having abdominal obesity (OR = 1.18, 95% CI, 1.01–1.38) and triglyceride ≥ 150 mg/dL (OR = 1.18, 95% CI, 1.04–1.34) were significantly increased after adjusting for age, sex, and BMI. Conclusions. In adolescents with obesity, TSH was higher and FT4 was lower than in adolescents with normal weight. Hyperthyrotropinemia was associated with abnormal metabolic risk factors including abdominal obesity and elevated triglyceride.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Seung Jae Kim ◽  
Oh. Deog Kwon ◽  
Kyung-Soo Kim

Abstract Background This study aimed to investigate the prevalence, awareness, treatment, and control rates of dyslipidemia and identify the predictors of optimal control (low-density lipoprotein cholesterol < 100 mg/dL) among patients with diabetes mellitus (DM). Methods A cross-sectional study was conducted using the representative Korea National Health and Nutrition Examination Survey (2014–2018). Overall, 4311 patients with DM, aged ≥19 years, and without cardiovascular diseases were selected, and the prevalence, awareness, treatment, and control rates of dyslipidemia were calculated. Univariate and multivariate logistic regression analyses were conducted to evaluate the factors influencing the optimal control of dyslipidemia. Results Dyslipidemia was prevalent in 83.3% of patients with DM, but the awareness and treatment rates were 36.5 and 26.9%, respectively. The control rate among all patients with dyslipidemia was 18.8%, whereas it was 61.1% among those being treated. Prevalence and awareness rates were also significantly higher in women than in men. Dyslipidemia was most prevalent in those aged 19–39 years, but the rates of awareness, treatment, and control among all patients with dyslipidemia in this age group were significantly lower than those in other age groups. The predictors of optimal control were age ≥ 40 years [range 40–49 years: adjusted odds ratio (aOR) 3.73, 95% confidence interval (CI) 1.43–9.72; 50–59 years: aOR 6.25, 95% CI 2.50–15.65; 60–69 years: aOR 6.96, 95% CI 2.77–17.44; 70–79 years: aOR 9.21, 95% CI 3.58–23.74; and ≥ 80 years: aOR 4.43, 95% CI 1.60–12.27]; urban living (aOR 1.44, 95% CI 1.15–1.80); higher body mass index (aOR 1.27, 95% CI 1.13–1.42); lower glycated hemoglobin levels (aOR 0.71, 95% CI 0.67–0.76); hypertension (aOR 1.53, 95% CI 1.22–1.92); poorer self-rated health status (aOR 0.72, 95% CI 0.62–0.84); and receiving regular health check-ups (aOR 1.58, 95% CI 1.25–2.00). Conclusions Most patients with DM were diagnosed with dyslipidemia, but many were unaware of or untreated for their condition. Therefore, their control rate was suboptimal. Thus, by understanding factors influencing optimal control of dyslipidemia, physicians should make more effort to encourage patients to undergo treatment and thus, adequately control their dyslipidemia.


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