Fasciitis by Lactococcus garvieae on an immunosuppressed patient by Diabetes Mellitus

Lactococcus garvieae, a gram-positive anaerobe facultative coccus, is a well-known pathogen in the aquaculture and cattle sector, being extremely rare for human beings. There are some case reports of infections caused by this microorganism, however, there are no fasciitis cases up to date. This is a case of a 24-year-old patient with uncontrolled diabetes mellitus and previous COVID-19 pneumonia without sequelae, admitted to the emergency room for a case compatible with fasciitis. Three cultures for L. garvieae were obtained from surgical debridement and microbiological studies were performed using automated VITEK-2 equipment. No posterior complications were documented. The patient went through a skin graft with a favorable response without evidence of clinical relapse.

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Primary mitochondrial disorders and diabetes mellitus - two case reports

Endocrine Abstracts ◽

10.1530/endoabs.56.ep36 ◽

2018 ◽

Author(s):

Lucia Fadiga ◽

Joana Saraiva ◽

Diana Oliveira ◽

Adriana Lages ◽

Mara Ventura ◽

...

Keyword(s):

Diabetes Mellitus ◽

Case Reports ◽

Mitochondrial Disorders

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Plasma vasopressin in uncontrolled diabetes mellitus

Diabetes ◽

10.2337/diabetes.28.5.503 ◽

1979 ◽

Vol 28 (5) ◽

pp. 503-508 ◽

Cited By ~ 29

Author(s):

R. L. Zerbe ◽

F. Vinicor ◽

G. L. Robertson

Keyword(s):

Diabetes Mellitus ◽

Plasma Vasopressin ◽

Uncontrolled Diabetes

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Decreased phospholipase A2 activity in plasma and liver in uncontrolled diabetes mellitus. A defect in the early steps of prostaglandin synthesis?

Diabetes ◽

10.2337/diabetes.35.4.403 ◽

1986 ◽

Vol 35 (4) ◽

pp. 403-410 ◽

Cited By ~ 11

Author(s):

K. M. Shakir ◽

H. L. Reed ◽

J. T. O'Brian

Keyword(s):

Diabetes Mellitus ◽

Phospholipase A2 ◽

Prostaglandin Synthesis ◽

Uncontrolled Diabetes ◽

Phospholipase A2 Activity

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Association Between Awareness of Informal Caregivers and Falls in Elderly Patients with Uncontrolled Diabetes Mellitus

The Open Public Health Journal ◽

10.2174/1874944502013010658 ◽

2020 ◽

Vol 13 (1) ◽

pp. 658-666

Author(s):

Tossapon Chamnankit ◽

Parichat Ong-artborirak ◽

Jukkrit Wangrath

Keyword(s):

Diabetes Mellitus ◽

Elderly Patients ◽

Elderly People ◽

Informal Caregivers ◽

Multivariable Analysis ◽

P Value ◽

Uncontrolled Diabetes ◽

Risk Of Falls ◽

The Mean ◽

Falls In Elderly

Background: Elderly people with uncontrolled diabetes mellitus (DM) are at risk of falls, which can lead to injury and disability. Not much is known of informal caregivers’ awareness of falls in elderly patients with DM. Objective: This study aims to identify an association between caregiver’s awareness and falls in elderly patients with DM. Methods: A total of 136 pairs of DM patients and their respective family caregivers were recruited from a clinical service center at Chiang Mai University, Thailand. The questionnaire regarding the caregiver’s awareness of the risk of falls in elderly patients was given via a face-to-face interview. Each elderly patient was asked about their history of falls in the prior year, and the risk of falls was assessed by Time Up & Go (TUG) test. Logistic regression analysis was performed to determine association. Results: The mean age of the DM patients was 65.7 years. Sixty-two patients (45.6%) had fallen at least once in the prior year. The mean TUG test result was 12.67±1.83 second. Most caregivers demonstrated a high level of awareness regarding the risk of falls in elderly patients. The results of the multivariable analysis showed that three variables – balance problems, risk of falls assessed by TUG test, and scores of caregiver’s awareness of risk of falls – were significantly related to falls in the previous year among elderly patients with DM (p-value<0.05). Conclusion: The caregivers’ awareness of fall risk may influence fall occurrence among older adults with DM. An intervention program to improve awareness among informal caregivers should be considered for fall prevention in elderly people.

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When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis

Journal of Fungi ◽

10.3390/jof7040298 ◽

2021 ◽

Vol 7 (4) ◽

pp. 298

Author(s):

Teny M. John ◽

Ceena N. Jacob ◽

Dimitrios P. Kontoyiannis

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Clinical Features ◽

The Other ◽

Diabetic Patients ◽

Epidemiological Factors ◽

Uncontrolled Diabetes ◽

Diagnostic Certainty ◽

Patients With Diabetes ◽

Perfect Storm

Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19.

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Bittersweet: infective complications of drug-induced glycosuria in patients with diabetes mellitus on SGLT2-inhibitors: two case reports

BMC Infectious Diseases ◽

10.1186/s12879-021-05982-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Caroline Bartolo ◽

Victoria Hall ◽

N. Deborah Friedman ◽

Chloe Lanyon ◽

Andrew Fuller ◽

...

Keyword(s):

Diabetes Mellitus ◽

Fungal Infections ◽

Case Reports ◽

Sglt2 Inhibitor ◽

Sglt2 Inhibitors ◽

Urogenital Tract ◽

Hypoglycemic Agents ◽

Drug Induced ◽

First Case ◽

Increased Risk

Abstract Background Sodium-glucose co-transporter 2 (SGLT2) inhibitors are novel hypoglycemic agents which reduce reabsorption of glucose at the renal proximal tubule, resulting in significant glycosuria and increased risk of genital mycotic infections (GMI). These infections are typically not severe as reported in large systematic reviews and meta-analyses of the medications. These reviews have also demonstrated significant cardiovascular benefits through other mechanisms of action, making them attractive options for the management of Type 2 diabetes mellitus (T2DM). We present two cases with underlying abnormalities of the urogenital tract in which the GMI were complicated and necessitated cessation of the SGLT2 inhibitor. Case presentations Both cases are patients with T2DM on empagliflozin, an SGLT2 inhibitor. The first case is a 64 year old man with Candida albicans balanitis and candidemia who was found to have an obstructing renal calculus and prostatic abscess requiring operative management. The second case describes a 72 year old man with Candida glabrata candidemia who was found to have prostatomegaly, balanitis xerotica obliterans with significant urethral stricture and bladder diverticulae. His treatment was more complex due to fluconazole resistance and concerns about urinary tract penetration of other antifungals. Both patients recovered following prolonged courses of antifungal therapy and in both cases the SGLT2 inhibitor was ceased. Conclusions Despite their cardiovascular benefits, SGLT2 inhibitors can be associated with complicated fungal infections including candidemia and patients with anatomical abnormalities of the urogenital tract may be more susceptible to these infections as demonstrated in these cases. Clinicians should be aware of their mechanism of action and associated risk of infection and prior to prescription, assessment of urogenital anatomical abnormalities should be performed to identify patients who may be at risk of complicated infection.

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Staphylococcal Sepsis with Multiple Abscesses, Urinary Tract Infection, and Bilateral Renal Vein Thrombosis in a Patient with Uncontrolled Diabetes Mellitus

Case Reports in Medicine ◽

10.1155/2012/357502 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Malik A. A. Khan ◽

Jonathan Michael Hunter ◽

Christopher Tan ◽

Mostafa Seleem ◽

Peter J. O. Stride

Keyword(s):

Diabetes Mellitus ◽

Staphylococcus Aureus ◽

Renal Vein ◽

Medical Condition ◽

Vascular Complications ◽

Renal Vein Thrombosis ◽

Intravenous Antibiotic ◽

Incision And Drainage ◽

Vein Thrombosis ◽

Uncontrolled Diabetes

We report a case of staphylococcal sepsis with vascular complications including peripheral emboli and renal vein thrombosis. Bilateral renal vein thrombosis has not been reported as a complication ofStaphylococcus aureus(SA) axillary abscess. Uncontrolled diabetes was the only detected predisposing medical condition. The patient was treated successfully with incision and drainage of soft-tissue abscesses and intravenous antibiotic for six weeks and with anticoagulation for renal vein thrombosis.

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