scholarly journals Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis

2021 ◽  
pp. 11-19
Author(s):  
Djuraev Jamolbek Abdukhakhorovich ◽  
Keyword(s):  
Quality Of Life ◽  
High Frequencies ◽  
Tlr2 Gene ◽  
Il10 Gene ◽  
Intracranial Complications ◽  
Hardy Weinberg Equilibrium ◽  
And Performance ◽  
High Level

Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.

scholarly journals Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis

2021 ◽  
Vol 1 (2) ◽  
pp. 11-19
Author(s):  
Djuraev Jamolbek Abdukhakhorovich* ◽  
Keyword(s):  
Quality Of Life ◽  
High Frequencies ◽  
Tlr2 Gene ◽  
Il10 Gene ◽  
Intracranial Complications ◽  
Hardy Weinberg Equilibrium ◽  
And Performance ◽  
High Level

Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.

When Your Ankle Becomes a Knee – Long-Term Functional Outcome and Quality of Life with a Rotationplasty after Resection of Malignant Limb Tumors

2021 ◽  
Author(s):  
Jennifer Gotta ◽  
Stefan Bielack ◽  
Stefanie Hecker-Nolting ◽  
Benjamin Sorg ◽  
Matthias Kevric ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Bone Cancer ◽  
Activity Level ◽  
Long Term Results ◽  
Level Scale ◽  
High Level

Abstract Background Increasing numbers of patients surviving malignant bone tumors around the knee joint have led to an increasing importance to investigate long-term results. This study assessed the long-term results of rotationplasty after resection of malignant bone tumors regarding functional outcome and quality of life to allow better comparison with other treatment options in bone cancer treatment. Procedure 60 participants who underwent rotationplasty due to bone cancer took part in this multicentric questionnaire-based study. The long-term functional outcome was measured by the Musculoskeletal tumor society score (MSTS) and the Tegner activity level scale. The health-related quality of life (HRQL) was assessed by using the Short Form Health Survey (SF-36). Results Patients treated with rotationplasty (median follow-up of 22 years, range 10–47 years) regained a high level of activity (median MSTS score of 24). Even a return to high level sports was possible (mean Tegner activity level scale of 4). Duration of follow-up did not influence the functional outcome. HRQL scores were comparable to the general German population. Concerns of psychological problems due to the unusual appearance of the rotated foot have not been confirmed. Conclusion Rotationplasty can be a good alternative to endoprosthetic replacement or amputation, either as primary surgery or as a salvage procedure. Especially for growing children and very active patients rotationplasty should be considered.

Long-Term Forecasting of World Economy

2014 ◽  
pp. 5-14
Author(s):  
Y. Lukashin ◽  
L. Rakhlina
Keyword(s):  
Quality Of Life ◽  
Life Quality ◽  
Developed Countries ◽  
New Era ◽  
Spare Time ◽  
Processing Gain ◽  
Long Term Forecasting ◽  
High Level

The paper considers contemporary approaches of long-term forecasting of world and national economics. Foreign practice is of especial interest of authors. Researches and results of PricewaterhouseCoopers and Goldman Sachs are exposed in details. Authors make the following conclusions: a production function model is used often to generate forecasts. The parameters of these models are postulated by experts in coincidence with their scenario of World development. Main indicators to forecast are GDP, GDP per capita and changes in country ranks. Authors consider GDP as not ideal indicator for the goal since it may be calculated by three methods. Besides, it has different structure and quality in different countries. Authors point to the need for estimation and comparison of quality of life. They suggest to take into account the revolutionary changing in technologies and to schedule the optimum and the most realistic path to improve the quality of life. Authors suggest that the most developed countries are entering a new era when robots will work more and more instead of people in industry, agriculture, and services. Many operations in control, management and data processing gain higher productivity due to endless progress in computer science. As a result authors foresee further shortening of the working week. On their opinion this is the way which leads to real success in struggle against unemployment. ICT technologies enable many employees to work now at home. Growing of spare time leads to new pattern of life, new possibilities of education, new types of creative work, new possibilities of communication, additional possibilities for health care, high level of life quality. So far, comparison of national economy development on the basis of measuring GDP seems to become obsolete and irrelevant to current social and economic conditions. Now we can expect to see negative rates of GDP growth and augmentation of life quality. Thus, to construct the countries’ ranks in world competition correctly it is of great importance to take into account the social factors and the role of innovation technologies in world economic development.

scholarly journals Diagnosis and Management of Neuroendocrine Disorders of Survivors of Brain Tumors

2021 ◽  
pp. 1-9
Author(s):  
Dana Erickson ◽  
Diane Donegan
Keyword(s):  
Quality Of Life ◽  
Growth Hormone ◽  
Brain Tumors ◽  
Hormone Deficiency ◽  
Adult Growth ◽  
Adults And Children ◽  
Receive Treatment ◽  
High Level

Advances in the treatment of brain tumors have led to an increase in the number of survivors of this disease. Consequently, the long-term complications associated with past and current treatments are becoming more apparent. Of relevance to patients who receive treatment of brain tumors are the potential neuroendocrine complications that develop either acutely or several years following treatment. Presentation may differ between adults and children (e.g., short stature or adult growth hormone deficiency) but in both settings can complicate treatment and impact quality of life. The risk for the development of these complications depends on the location of the tumor (proximity to the pituitary/hypothalamus) and/or the treatment delivered (chemotherapy/surgery/radiation). Given the potential overlap in symptoms attributable to the underlying brain tumor and neuroendocrine dysfunction, a high level of suspicion, appropriate investigation, and administration of treatment may reduce morbidity and mortality for patients with brain tumors experiencing neuroendocrine dysfunction.

scholarly journals Physical Activity and Performance Impact Long-term Quality of Life in Older Adults at Risk for Major Mobility Disability

2019 ◽  
Vol 56 (1) ◽  
pp. 141-146 ◽  
Author(s):  
Erik J. Groessl ◽  
Robert M. Kaplan ◽  
W. Jack Rejeski ◽  
Jeffrey A. Katula ◽  
Nancy W. Glynn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
At Risk ◽  
Mobility Disability ◽  
Performance Impact ◽  
And Performance

Long-term studies of antipsychotic drugs in schizophrenia

1996 ◽  
Vol 11 (3) ◽  
pp. 127-134 ◽  
Author(s):  
T Lewander
Keyword(s):  
Quality Of Life ◽  
Rating Scales ◽  
Assessment Instruments ◽  
Main Concern ◽  
Drug Induced ◽  
Safety Issues ◽  
And Performance ◽  
Long Term Studies

SummaryStudies on long-term efficacy and safety should be a main concern in the evaluation of novel antipsychotics. The present paper is a review of important issues related to the design and performance of such trials. The variability of the natural course of schizophrenia, the variability in treatment response, and the variability of actions of different neuroleptics need to be considered. Long-term studies need to address maintenance of efficacy, prevention of relapse and recurrence, health economics, quality of life and a large number of safety issues in order to get approval for new drug applications and reimbursement on expensive new medicines. Assessment instruments for efficacy, tolerability and safety, need to be supplemented with rating scales for various aspects of psychopathology (positive, negative, deficit symptoms), social and work functioning, drug induced mental side effects, quality of life and accounts of total treatment costs.

scholarly journals QUALITY OF LIFE OF HEMODIALYSIS PATIENTS WITH ARTERIOVENOUS FISTULA

2017 ◽  
pp. 47-52
Author(s):  
I. Rusyno ◽  
O. Tsiupiaka
Keyword(s):  
Quality Of Life ◽  
Arteriovenous Fistula ◽  
Chronic Hemodialysis ◽  
Daily Routine ◽  
Men And Women ◽  
Psychological Indicators ◽  
And Performance ◽  
High Level ◽  
The Impact

Objective: to study the basic quality of life in patients with chronic kidney disease and their relationship, with different numbers formed arteriovenous fistula. Materials and methods. Interviewed 56patients, who are treated with chronic hemodialysis department. To study the quality of life used (KDQOL-SF ™). Also used a questionnaire that enables presence fistula determine the impact on quality of life of patients. Results. Using statistical method cluster analysis, made differentiation studied three groups - clusters, which differ in different levels of the indicators of QOL, namely «Patients middle-manifestation of physical and psychological indicators of QOL» – 40%, «Patients with low the manifestation of physical and psychological QOL parameters «- 25% of subjects, and» Patients with high level of physical and psychological manifestations of QOL performance «- 35% sample of of the patients. Based on statistical comparative analysis revealed differences between the estimated quality of life in men and women. Role functioning due to physical condition in women is slightly lowered than men. In women, there is a greater level of pain than men. Men overall higher rate their health than women. Men are characterized by a higher level of social functioning than women. Conclusions. Patients with chronic hemodialysis age have difficulties in physical functioning and performance of daily affairs. Mental health by increasing the biological age becomes stronger and fitter. His attitude to the presence of fistula in upper limb showing men and women equally, that they feel discomfort and limitations in performing daily routine. The more surgeries performed to form vascular access in patients, the occurrence characteristically uncomfortable sensations in all aspects of life

scholarly journals When your ankle becomes a knee - a clinical study on long-term functional outcome and quality of life with a rotationplasty after resection of malignant limb tumors

2021 ◽  
Author(s):  
Jennifer Gotta ◽  
Stefan Bielack ◽  
Stefanie Hecker Nolting ◽  
Benjamin Sorg ◽  
Matthias Kevric ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Bone Cancer ◽  
Activity Level ◽  
Long Term Results ◽  
Level Scale ◽  
High Level

Background Increasing numbers of patients surviving malignant bone tumors around the knee joint have led to an increasing importance to investigate long-term results. This study assessed the long-term results of rotationplasty after resection of malignant bone tumors regarding functional outcome and quality of life to allow better comparison with other treatment options in bone cancer treatment. Procedure 60 participants who underwent rotationplasty due to bone cancer took part in this multicentric questionnaire-based study. The long-term functional outcome was measured by the Musculoskeletal tumor society score (MSTS) and the Tegner activity level scale. The health-related quality of life (HRQL) was assessed by using the Short Form Health Survey (SF-36). Results Patients treated with rotationplasty (median follow-up of 22 years, range 10-47 years) regained a high level of activity (median MSTS score of 24). Even a return to high level sports was possible (mean Tegner activity level scale of 4). Duration of follow-up did not influence the functional outcome. HRQL scores were comparable to the general German population. Concerns of psychological problems due to the unusual appearance of the rotated foot have not been confirmed. Conclusion Rotationplasty can be a good alternative to endoprosthetic replacement or amputation, either as primary surgery or as a salvage procedure. Especially for growing children and very active patients rotationplasty should be considered.

Integrated study of land use conditions in Nefteyugansk Khanty-Mansi autonomous okrug–Yugra

2021 ◽  
pp. 843-852
Author(s):  
Y.M. Rogatnev ◽  
V.N. Shcherba ◽  
S.Yu. Komarova ◽  
O.S. Abramova
Keyword(s):  
Quality Of Life ◽  
Land Use ◽  
The State ◽  
High Level ◽  
Integrated Study ◽  
Khanty Mansi Autonomous ◽  
Comprehensive Study

The article deals with the comprehensive study of the most valuable lands in Nefteyugansk. Determining the prospects for land use has long-term and significant implications for the quality of life. The high level of investment support for development leads to the need for accurate, comprehensive accounting not only of the state of lands, but especially the conditions of their functioning.

scholarly journals Evaluation of Human Capital in the Macroregion (on the Example of the Yenisey Siberia)

2020 ◽  
pp. 1808-1818
Author(s):  
Irina P. Vorontsova ◽  
Ludmila K. Vitkovskaya ◽  
Ivan A. Drobyshev
Keyword(s):  
Quality Of Life ◽  
Human Capital ◽  
Natural Resource ◽  
Statistical Data ◽  
Interdisciplinary Approach ◽  
Information Support ◽  
Key Indicator ◽  
High Level

The article is devoted to the problem of measuring and estimating the human capital of the natural resource macroregion, whose territory is characterized by a high level of social and economic asymmetry. It presents results of testing of modified index of human capital in context of interdisciplinary approach. The study was based on survey findings, along with statistical data. The satisfaction of the population with the quality of life is a key indicator of the dynamics of human capital in the long term. The authors give recommendations on the development of information support of territorial policy

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