Ovary and Uterus, Rare Sites of Metastases from Breast Cancer: A Case Series

Abstract Background Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis. Claudins (CLDN) belong to tight junction integrity and are dysregulated in BrCa. Thus far, epidemiologic evidence regarding the association of different pro-metastatic genes with pathological phenotypes of BrCa is largely inconsistent. This study aimed to determine the possible transcriptional models of pro-metastatic genes incorporate in holding the integrity of epithelial cell–cell junctions (CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4), for the first time, in association with clinicopathological features of primary BrCa. Methods In a consecutive case-series design, 206 newly diagnosed non-metastatic eligible BrCa patients with histopathological confirmation (30–65 years) were recruited in Tabriz, Iran (2015–2017). Real-time RT-PCR was used. Then fold changes in the expression of target genes were measured. Results ROCK amplification was associated with the involvement of axillary lymph node metastasis (ALNM; ORadj. = 3.05, 95%CI 1.01–9.18). Consistently, inter-correlations of CTTN-ROCK (β = 0.226, P < 0.05) and RhoA-ROCK (β = 0.311, P < 0.01) were determined among patients diagnosed with ALNM+ BrCa. In addition, the overexpression of CLDN-4 was frequently observed in tumors identified by ALNM+ or grade III (P < 0.05). The overexpression of CTTN, CLDN-1, and CLDN-4 genes was correlated positively with the extent of tumor size. CTTN overexpression was associated with the increased chance of luminal-A positivity vs. non-luminal-A (ORadj. = 1.96, 95%CI 1.02–3.77). ROCK was also expressed in luminal-B BrCa tumors (P < 0.05). The estrogen receptor-dependent transcriptions were extended to the inter-correlations of RhoA-ROCK (β = 0.280, P < 0.01), ROCK-CLDN-2 (β = 0.267, P < 0.05), and CLDN-1-CLDN-4 (β = 0.451, P < 0.001). Conclusions For the first time, our findings suggested that the inter-correlations of CTTN-ROCK and RhoA-ROCK were significant transcriptional profiles determined in association with ALNM involvement; therefore the overexpression of ROCK may serve as a potential molecular marker for lymphatic metastasis. The provided binary transcriptional profiles need more approvals in different clinical features of BrCa metastasis.

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Case series: Breast and ovarian cancer syndrome

10.1055/s-0039-1685348 ◽

2016 ◽

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Brca Mutation ◽

Family Members ◽

Case Series ◽

Second Primary ◽

Time Interval ◽

Breast And Ovarian Cancer ◽

Ovarian Carcinomas ◽

Increased Risk

Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1,2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.

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High-dose intravenous methotrexate in the management of breast cancer with leptomeningeal disease: Case series and review of the literature

Hematology/Oncology and Stem Cell Therapy ◽

10.1016/j.hemonc.2019.08.008 ◽

2019 ◽

Vol 12 (4) ◽

pp. 189-193 ◽

Cited By ~ 3

Author(s):

Jonathan T. Kapke ◽

Robert J. Schneidewend ◽

Zeeshan A. Jawa ◽

Chiang-Ching Huang ◽

Jennifer M. Connelly ◽

...

Keyword(s):

Breast Cancer ◽

Case Series ◽

Leptomeningeal Disease ◽

High Dose ◽

Review Of The Literature ◽

Disease Case

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Breast Cancer in Transgender Veterans: A Ten-Case Series

LGBT Health ◽

10.1089/lgbt.2014.0123 ◽

2015 ◽

Vol 2 (1) ◽

pp. 77-80 ◽

Cited By ~ 26

Author(s):

George R. Brown

Keyword(s):

Breast Cancer ◽

Case Series

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Adjuvant endocrine therapy impact on bone health in premenopausal women with hormone receptor-positive breast cancer: Results of a case series

Endocrine Abstracts ◽

10.1530/endoabs.73.aep145 ◽

2021 ◽

Author(s):

Diana Lambrinoc ◽

Duşceac Roxana ◽

Alexandru Morea ◽

Poiană Cătălina

Keyword(s):

Breast Cancer ◽

Endocrine Therapy ◽

Bone Health ◽

Hormone Receptor ◽

Case Series ◽

Premenopausal Women ◽

Adjuvant Endocrine Therapy ◽

Hormone Receptor Positive ◽

Positive Breast Cancer

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Axillary Web Syndrome in Breast Cancer: A Prevalent But Under-Recognized Postoperative Complication

Breast Care ◽

10.1159/000485023 ◽

2018 ◽

Vol 13 (2) ◽

pp. 129-132 ◽

Cited By ~ 6

Author(s):

Susan R. Harris

Keyword(s):

Breast Cancer ◽

Cohort Studies ◽

Systematic Reviews ◽

Nurse Practitioners ◽

Case Reports ◽

Case Series ◽

Diagnosis And Management ◽

Oncology Nurse ◽

Management Interventions ◽

Axillary Web Syndrome

The purpose of this review is to define axillary web syndrome (AWS) and describe its diagnosis and management. The following databases were searched through July 2017: PubMed, EMBASE (OvidSP), Cumulative Index for Nursing and Allied Health Literature, Physiotherapy Evidence Database, and Cochrane Database of Systematic Reviews. Search terms included ‘axillary web syndrome', ‘axillary cording', and ‘lymphatic cording'. 49 articles were identified; 8 did not relate to breast cancer, and 3 were not in English. Of the remaining articles, the majority were case reports, case series, or descriptive reviews. 2 systematic reviews were located as well as 1 randomized trial, 6 prospective cohort studies, and 2 retrospective cohort studies. Although a common sequela after axillary surgery for breast cancer staging, AWS has been poorly described in the medical literature as to the underlying pathophysiology, diagnosis, and management. Interventions range from patient education and simple reassurance that the syndrome will resolve spontaneously to active physical or manual therapies to maintain upper extremity range-of-motion, especially adequate motion for undergoing radiation therapy. Oncologists, breast surgeons, family physicians, and oncology nurse practitioners that work with patients with breast cancer should educate them about this prevalent complication and inform them preoperatively about what to anticipate.

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Mimic Breast Cancer as the Location of a Penetrating Breast Artery: A Case Series

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2017.08.1030 ◽

2017 ◽

Vol 43 ◽

pp. S27

Author(s):

Chiaki Taniguchi ◽

Tomoyuki Ohta ◽

Makiko Nishioka ◽

Norio Nakata ◽

Takako Shirakawa ◽

...

Keyword(s):

Breast Cancer ◽

Case Series

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Successful treatment of cutaneous metastatic breast cancer with topical treatments that potentially synergize with systemic therapy: A case series

JAAD Case Reports ◽

10.1016/j.jdcr.2018.04.013 ◽

2018 ◽

Vol 4 (7) ◽

pp. 711-715 ◽

Cited By ~ 2

Author(s):

Shalini R. Krishnasamy ◽

Timothy H. Almazan ◽

Giselle A. Suero-Abreu ◽

Jae Y. Jung

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Successful Treatment ◽

Systemic Therapy ◽

Case Series ◽

Metastatic Breast ◽

Topical Treatments

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The effect of hyperbaric oxygen treatment on late radiation tissue injury after breast cancer: A case-series of 67 patients

Diving and Hyperbaric Medicine Journal ◽

10.28920/dhm50.3.206-213 ◽

2020 ◽

Vol 50 (3) ◽

pp. 206-213

Author(s):

Nicole E Spruijt ◽

◽

Roy van den Berg ◽

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Hyperbaric Oxygen ◽

Tissue Injury ◽

Case Series ◽

Shoulder Abduction ◽

Hyperbaric Oxygen Treatment ◽

Normal Tissues ◽

Oxygen Treatment ◽

Shoulder Motion

Introduction: Late radiation tissue injury (LRTI) after breast cancer may benefit from hyperbaric oxygen treatment (HBOT). This study aimed to report the LRTI symptom scores up to 12 months after HBOT and identify risk factors for poor scores. Methods: A case-series of 67 patients who underwent a mean of 44 sessions of HBOT was analysed. LRTI symptoms were scored at four time points using the LENT-SOMA scale (Late Effects in Normal Tissues – Subjective, Objective, Management, and Analytic), a visual analog scale for pain, and the range of shoulder motion. Results: Between starting HBOT and 12 months after HBOT 57 patients (85%) reported at least one point improvement in their LENT-SOMA score. Median pain and fibrosis scores improved significantly between the start and end of HBOT (P < 0.001), and remained stable three and 12 months after HBOT. The median breast oedema score improved significantly 12 months after HBOT (P = 0.003). Median shoulder abduction increased significantly from 90 to 165 degrees (P = 0.001) and median shoulder anteflexion increased significantly from 115 to 150 degrees (P = 0.004). Various risk factors were identified for poor scores despite HBOT; the most common risk factor was a poor score at start of HBOT. Conclusions: In this case-series, patients who underwent HBOT for LRTI after breast cancer reported significant improvement in pain, fibrosis, oedema, and shoulder movement. The improvement persisted up to 12 months after HBOT. A poor score at the start of HBOT was predictive for a poor score 12 months after HBOT.

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