Anti-tumor effects of polyphenolic compounds of Camellia sinensis, Nigella sativa, Matricaria chamomilla and Triticum aesativum against Ehrlich ascites carcinoma mouse model

2017 ◽  
pp. 1
Author(s):  
Mohamed Salem ◽  
Abeer Khamis ◽  
AbdelHalim Mostafa ◽  
Ehab Ali
Keyword(s):  
Mouse Model ◽  
Camellia Sinensis ◽  
Nigella Sativa ◽  
Ehrlich Ascites Carcinoma ◽  
Polyphenolic Compounds ◽  
Matricaria Chamomilla ◽  
Ehrlich Ascites

Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma

2019 ◽  
Vol 46 (5) ◽  
pp. 496-505 ◽  
Author(s):  
Huda Mohammed Alkreathy ◽  
Mayson H. Alkhatib ◽  
Safaa Ahmed Al Musaddi ◽  
Khadijah Saeed A. Balamash ◽  
Nadia Nour Osman ◽  
...  
Keyword(s):  
Mouse Model ◽  
Antitumour Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Swiss Albino Mouse ◽  
Ehrlich Ascites

scholarly journals Immunomodulatory and anti-tumor effects ofNigella glanduliferafreyn and sint seeds on ehrlich ascites carcinoma in mouse model

2013 ◽  
Vol 9 (35) ◽  
pp. 187 ◽  
Author(s):  
Dilinuer Maimaitiyiming ◽  
Meiliwan Abudureyimu ◽  
Ainiwaer Aikemu ◽  
Xiadiya Xiaerfuding ◽  
Chengyufeng Shiwenhui
Keyword(s):  
Mouse Model ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites

scholarly journals Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

2020 ◽  
Vol 7 (11) ◽  
pp. 4100-4113
Author(s):  
Hamed A. Abosharaf ◽  
Mohammed Salah ◽  
Thoria Diab ◽  
Motonari Tsubaki ◽  
Tarek M. Mohamed
Keyword(s):  
Silver Nanoparticles ◽  
Mouse Model ◽  
Combined Treatment ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Liver And Kidney ◽  
Mango Leaves ◽  
Eac Cells

Introduction: Plant-mediated synthesis of silver nanoparticles (AgNPs) is accounted as an ecofriendly process. The present study was conducted to estimate the potency of biogenic AgNPs against Ehrlich ascites carcinoma (EAC) cells in vitro and EAC-bearing mice in vivo. Methods: AgNPs were prepared using mango leaves extract and characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscopy (TEM). Ehrlich ascites carcinoma (EAC) mouse model was established by intraperitoneal injection of 1 x 106 EAC cells. Biogenic AgNPs- alone or combined with Doxorubicin (DOX)- was administered intraperitoneally day by day for two weeks. Results: Biologically synthesized AgNPs showed a cytotoxic effect against cultured EAC cells but with less toxicity toward normal cells compared to DOX, which had strong cytotoxicity against both cells. Biogenic AgNPs alone or combined with DOX triggered the cytotoxicity against the EAC-bearing mouse model via decreasing body weight, tumor volume, and the number of viable tumor cells. The combined treatment (AgNPs-DOX) ameliorated the drastic effect induced by injection of EAC cells through improving liver and kidney functions compared to those treated with DOX alone. In addition, the combined treatment showed an elevation in the expression of Bax and caspase-3, and a reduction in the expression of Bcl-2 protein in the EAC cells. Furthermore, this combined treatment effectively arrested the cell cycle at the G0/G1 phase. Moreover, the combined treatment with AgNPs-DOX caused a significant reduction in the activity of ornithine decarboxylase (ODC). Conclusion: These findings suggest that biogenic AgNPs could be useful in developing a potent combination therapy against different types of cancers.

Trichosanthes dioica seed lectin inhibits Ehrlich ascites carcinoma cells growth in vivo in mice by inducing G 0 /G 1 cell cycle arrest

2021 ◽  
Author(s):  
Shaikh Shohidul Islam ◽  
Md. Rezaul Karim ◽  
A. K. M. Asaduzzaman ◽  
A. H. M. Khurshid Alam ◽  
Zahid Hayat Mahmud ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Ehrlich Ascites ◽  
Trichosanthes Dioica

Antioxidant, cytotoxic and apoptotic potentials of seeds of Momordica subangulata subsp. renigera inhibit the growth of Ehrlich ascites carcinoma in mice

2019 ◽  
Vol 13 (4) ◽  
pp. 3049-3059
Author(s):  
Polash Chandra Karmakar ◽  
Rumana Yesmin ◽  
Hanif Ali ◽  
M. Rowshanul Habib ◽  
Dhirendra Nath Barman ◽  
...  
Keyword(s):  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites
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