scholarly journals Some effects of simultaneous administration of crude aqueous extracts of Mangifera indica leaves and tetracyline on the liver of adults wistar rats

1970 ◽  
Vol 6 (2) ◽  
pp. 934-942
Author(s):  
M.S. Peterson ◽  
Adesina J. Ajibade ◽  
Peter B. Olaitan
Keyword(s):  
Adverse Effect ◽  
Aqueous Extract ◽  
Therapeutic Dose ◽  
Wistar Rats ◽  
Mangifera Indica ◽  
Liver Histology ◽  
Central Vein ◽  
Hepatic Enzymes ◽  
Mango Leaves ◽  
Crude Aqueous Extract

This study was designed to determine the simultaneous effect of Mangifera indica crude aqueous extract and the therapeutic dose of tetracycline on some hepatic enzymes (ALT and AST) and histology of the liver of adult wistar rats. 25 wistar rats were divided into 5 groups: Group A was untreated and served as control group, group B was treated with only 2mL of mango leaves decoction, group C was treated with only 5.4mg/kg of tetracycline, group D was treated with 1mL of mango leaves decoction and 4.8mg/kg of tetracycline and group E was treated with 3mL of mango leaves decoction and 7.7mg/kg of tetracycline simultaneously. The administration period lasted for only 14 days which was given gavagely and the rats were sacrificed on the 15th day by cervical dislocation. The liver was removed, fixed in 10% formal saline and stained in H and E. The transaminase enzymes (the AST and ALT) were measured to determine possible changes in their hepatic leaves. The result shows that the crude aqueous extract of mango levels has adverse effect on the morphology and some hepatic enzyme (ALT and AST) of the liver (such as enlargement of the central vein, reduction in the size of sinusoids), the therapeutic dose of the tetracycline have no detrimental effect on the morphology and the hepatic enzymes of the liver. In conclusion, the extract of mango leaves decoction has adverse effect on the liver histology and the therapeutic dosage of tetracycline has no adverse effect on the histology of the liver.Keywords: Mango leaves, Tetracycline, Liver histology, Liver enzymes (AST and ALT)

scholarly journals Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227105
Author(s):  
Gustavo Roberto Villas Boas ◽  
João Marcos Rodrigues Lemos ◽  
Matheus William de Oliveira ◽  
Rafael Claudino dos Santos ◽  
Ana Paula Stefanello da Silveira ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Plasma Insulin ◽  
Mangifera Indica ◽  
Hypoglycemic Effect ◽  
Insulin Levels ◽  
Plasma Insulin Levels

scholarly journals Phytochemical Characterization, Hepatoprotective Activity on Alcohol-Induced Toxicity of the Aqueous Extract of Curcuma longa (Zingiberaceae) in Wistar Rats

2021 ◽  
pp. 134-149
Author(s):  
Ameaka Fatima Nkempu ◽  
Tembe Estella ◽  
Tchadji Mayoudom Vanessa Edwige ◽  
Bayaga Herve ◽  
Dobgima John Fonmboh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Secondary Metabolites ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Curcuma Longa ◽  
Hepatoprotective Activity ◽  
Bioactive Metabolites ◽  
Central Vein ◽  
Phytochemical Screening

Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chronic alcohol consumption is one of the most frequent causes of liver disease and accounts for about 55% of liver cirrhosis deaths recorded in Cameroon in 2020. Standard accessible treatments focus on end-stage liver disease with safety and efficacy obstacles. We have a research gap in Cameroon to understand the alternative use of natural products as treatment with a long traditional history of safe use. Curcuma longa has long been a source of traditional and modern medicine. It is commonly used in Cameroon as a spice and herbal product with some level of activity against various forms of liver disease. Objective: To phytochemically screen for bioactive metabolites and evaluate the hepatoprotective activity of the aqueous extract of Curcuma longaon alcohol-induced toxicity in Wistar rats. Methods: Phytochemical screening was carried out on the aqueous extract obtainedfrom maceration of plant rhizomes. Three doses (125, 250 and 500mg/Kg) of the plant extract and the reference (Silymarin 50mg/Kg) were administered daily (p.o) to rats 30 min before administration of 40% alcohol (2mL/100g p.o) for 21 days. Biochemical parameters such as ALAT, ASAT, GGT, Bilirubin and Lipid profile were quantified and histological studies of the liverwas carried out using standard procedures. Results: Phytochemical screening of the aqueous extract of C. longa revealed polyphenols such as flavonoids, tannins, quinones, saponins and phlobatanins. The plant showed hepatoprotective activity by decreasing liver toxicity markers such as ASAT, ALAT, GGT and Bilirubin. Histology revealed dose-dependent protection with 500 mg/Kg showing the most cellular integrity, no central vein occlusion and minimal fibrosis. Conclusion: This study indicated the presence of polyphenols like flavonoids and tannins in the aqueous extract of C. longa. The presence of these secondary metabolites in the studied extract justifies its antioxidant and anti-inflammatory properties confirmed by its hepatoprotective effects on alcohol-induced toxicity. This was clearly shown by biochemical and histological parameters. More sensitive and specific methods are required to test for these secondary metabolites in serum.

scholarly journals HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS

2021 ◽  
pp. 36-38
Author(s):  
ADETUNJI OPEYEMI ADEBOLA ◽  
OYEWO OLUWATOYIN ◽  
ADETUNJI IYABODE TOYIN ◽  
NWOBI NNENA LINDA
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
The Body ◽  
Damage Effect ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
The One ◽  
Convoluted Tubules ◽  
Crude Aqueous Extract

Aim and Objectives: Demonstrating the exact quantity of Moringa oleifera (MO) that will cure any hepatocyte diseases and the one that can harm the hepatocytes of the Adult Wistar rats. Methods: Twenty (20) adult Wistar rats (both sex) were used for the study (caged based on same sex to avoid mating and pregnancy) and were randomly assigned into four groups (n=5); A-Control, B-250 mg/body weight (BW) of MO, C-500 mg/BW of MO, and D-750 mg/BW of MO orally. Result: The crude aqueous extract of MO Lam, shows insignificant increased in BW at the 1st week of administration which latter dropped little by little doing the weeks of the administration in groups (B, C, and D) rats, by comparing (p<0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. MO increases the weight of the animals morphologically by comparing the weight of the animals before and after administration. Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats. Conclusion: MO is a good herb that has no damage effect on the body and hepatocytes but of more beneficial.

scholarly journals Efek Alelopati Ekstrak Air Daun Mangga (Mangifera indica L. Var. Arumanis) Terhadap Pertumbuhan Rumput Teki (Cyperus rotundus L.)

2020 ◽  
Vol 18 (3) ◽  
pp. 193
Author(s):  
Davina Nathania Prasetya ◽  
Zulkifli Zulkifli ◽  
Tundjung Tripeni Handayani ◽  
Martha L. Lande
Keyword(s):  
Water Content ◽  
Aqueous Extract ◽  
Mangifera Indica ◽  
Dry Weight ◽  
Shoot Length ◽  
Cyperus Rotundus ◽  
Fresh Weight ◽  
Purple Nutsedge ◽  
Extract Concentration ◽  
Mango Leaves

The purpose of this research is to know whether the aqueous extract of mango leaves(Mangifera indica L.) affect the growth of purple nutsedge (Cyperus rotundus L.). Thisresearch conducted at Botanical Laboratory of Biology Department Faculty of Mathematicsand the Natural Sciences University of Lampung from September to October 2017. Thisexperiments were carried out in a complete randomized design with the main factors beingaqueous extract of mango leaves with 5 level concentration : 0% w / v ( control), 5% w / v,10% w / v, 15% w / v, and 20% w / v and consist of 5 replications. Parameters measuredwere shoot length, fresh weight, dry weight, and relative water content. The Levene testdetermined the homogeneity of variance at 5% significant level. Analysis of variance andTukey HSD testis did at 5% significant level. The results showed that the concentration ofextract was negatively correlated with shoot length where the shoot length was decreasedsignificantly at 20% extract concentration. Total fresh weight was decreased significantly at20% and correlated linearly negative with extract concentration. Total dry weight wasdecreased significantly at 20% extract concentration. There was no significant effect onrelative water content. From this research, it concluded that aqueous extract of mangoleaves at 20% extract concentration was decreased shoot length, fresh weight and dry weightof purple nutsedge.

Biochemical and Haemopoietic Effects of Aqueous Extract of Gnetum Africanum (Ukazi) on Male and Female Albino Wistar Rats

2018 ◽  
Vol 8 (4) ◽  
pp. 061-065
Author(s):  
F.N OGUWIKE ◽  
◽  
I.C IFEDI ◽  
C.N DIM ◽  
C.P IGWEDIBIA ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Male And Female
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