Effect of Trema guineensis (celtidaceae) on ethanol-induced hypertension in Wistar rats.

2019 ◽  
Vol 4 (1) ◽  
pp. 9
Author(s):  
Balakiy KADISSOLI ◽  
Aklesso MOUZOU ◽  
Tcha PAKOUSSI ◽  
Kwashie GADEGBEKU ◽  
Kodjo AKLIKOKOU ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Induced Hypertension

Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic wistar rats

2009 ◽  
Vol 24 (S2) ◽  
pp. S196-S203 ◽  
Author(s):  
Mahalaxmi Mohan ◽  
Harshal Waghulde ◽  
Sanjay Kasture
Keyword(s):  
Angiotensin Ii ◽  
Wistar Rats ◽  
Pomegranate Juice ◽  
Induced Hypertension

Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region

1999 ◽  
Vol 276 (1) ◽  
pp. H63-H70 ◽  
Author(s):  
Shereeni J. Veerasingham ◽  
Frans H. H. Leenen
Keyword(s):  
Hypertonic Saline ◽  
Wistar Rats ◽  
Third Ventricle ◽  
Cardiovascular Responses ◽  
Ibotenic Acid ◽  
Air Jet ◽  
Artificial Cerebrospinal Fluid ◽  
Induced Hypertension ◽  
Chronic Infusion

To examine the role of the ventral anteroventral third ventricle (vAV3V) in the hypertension induced by chronic subcutaneous ouabain and intracerebroventricular hypertonic saline, neurons in this area were destroyed by microinjection of an excitotoxin, ibotenic acid. Sham-operated or lesioned Wistar rats were administered ouabain (50 μg/day) or placebo for 3 wk from subcutaneously implanted controlled release pellets or artificial cerebrospinal fluid (CSF) or CSF containing 0.8 mol/l NaCl (5 μl/h) infused intracerebroventricularly for 2 wk. At the end of the experiment, mean arterial pressure (MAP) and heart rate at rest and in response to ganglionic blockade by intravenous hexamethonium (30 mg/kg) were assessed. In rats infused with hypertonic saline, responses to air jet stress were also assessed. Baseline MAP in sham-operated rats receiving intracerebroventricular hypertonic saline or subcutaneous ouabain was significantly higher than in control rats (115 ± 1 vs. 97 ± 3 and 121 ± 3 vs. 103 ± 3 mmHg, respectively). vAV3V lesions abolished the increase in MAP elicited by chronic infusion of hypertonic saline or administration of ouabain. Sham-operated rats treated with hypertonic saline or ouabain exhibited significantly enhanced decreases in MAP to hexamethonium, but lesioned rats did not. Rats infused with hypertonic saline demonstrated enhanced responses to air jet stress that were similar in sham-operated and lesioned rats. These results demonstrate that neurons in the vAV3V are essential for the hypertension induced by intracerebroventricular hypertonic saline and subcutaneous ouabain, possibly by increasing sympathetic tone. Cardiovascular responses to air jet stress appear not to be mediated by the vAV3V.

scholarly journals Antihypertensive effect of methanol leaf extract of Anacardium occidentale against L‐Nitro Arginine Methyl Ester (L‐NAME)‐induced hypertension in male Wistar rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Adebowale Benard Saba ◽  
Adedeji Kolawole Adebayo ◽  
Ademola Adetokunbo Oyagbemi ◽  
Temidayo Olutayo Omobowale ◽  
Olufunke Eunice Ola-Davies ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Antihypertensive Effect ◽  
Anacardium Occidentale ◽  
Induced Hypertension ◽  
Male Wistar Rats

The Influence of Neonatal Treatment with Guanethidine on the Development of Isolation-Induced Hypertension in Adult Rats

1983 ◽  
Vol 65 (5) ◽  
pp. 469-474 ◽  
Author(s):  
S. M. Gardiner ◽  
T. Bennett
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Wistar Rats ◽  
Adult Rats ◽  
Male And Female ◽  
Neonatal Treatment ◽  
Induced Hypertension ◽  
Female Wistar Rats ◽  
Sympathetic Nervous

1. Rats housed individually in glass metabolism cages develop hypertension. Since previous experiments have provided some evidence for the involvement of the sympathetic nervous system in the maintenance of the hypertension, the present work was designed to explore the possible involvement of the sympathetic nervous system in the genesis of isolation-induced hypertension. 2. Male and female Wistar rats were treated neonatally with guanethidine, with a protocol designed to produce an extensive peripheral sympathectomy; control rats received saline. 3. The effects of isolation on systolic blood pressure and fluid and electrolyte balances were studied when the rats were mature. 4. Guanethidine-treated rats did not develop hypertension in response to isolation whereas control rats did. 5. There were no significant differences between the fluid and electrolyte balances of the guanethidine-treated rats compared with controls throughout the period of isolation. 6. It is concluded that a fully functional sympathetic nervous system is required for the development of isolation-induced hypertension, but its involvement is not through a modulation of renal function.

scholarly journals In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar rats

2015 ◽  
Vol 15 ◽  
pp. 294-300 ◽  
Author(s):  
Aurora García-Tejedor ◽  
María Castelló-Ruiz ◽  
José V. Gimeno-Alcañíz ◽  
Paloma Manzanares ◽  
Juan B. Salom
Keyword(s):  
Angiotensin Ii ◽  
Wistar Rats ◽  
Angiotensin I ◽  
Induced Hypertension

Dietary linoleic acid and salt-induced hypertension

1981 ◽  
Vol 59 (8) ◽  
pp. 872-875 ◽  
Author(s):  
Murray C. Macdonald ◽  
Robert L. Kline ◽  
Gordon J. Mogenson
Keyword(s):  
Blood Pressure ◽  
Linoleic Acid ◽  
Systolic Blood Pressure ◽  
Wistar Rats ◽  
Sodium Content ◽  
Significant Elevation ◽  
Dietary Linoleic Acid ◽  
Low Level ◽  
Induced Hypertension ◽  
Male Wistar Rats

Male Wistar rats chronically fed a low level (0.41%) of linoleic acid (LA) in the diet as supplied by 5% olive oil developed a significant elevation of systolic blood pressure as compared with rats fed either a medium (4.2%) or high (9.4%) level of dietary LA. Chronic excess intake of NaCl (3.75% in the diet) was associated with a significant elevation of blood pressure on all three diets but a low level of LA in the diet exaggerated the salt-induced hypertension. The results suggest that inadequate dietary LA may result in an increase in systolic blood pressure regardless of the sodium content of the diet.

Effect of Adrenalectomy on the Development of Isolation-Induced Hypertension in Rats

1981 ◽  
Vol 61 (5) ◽  
pp. 511-519 ◽  
Author(s):  
S. M. Gardiner ◽  
K. E. Milmer ◽  
T. Bennett
Keyword(s):  
Volume Expansion ◽  
Chloride Solution ◽  
Wistar Rats ◽  
Sodium Chloride Solution ◽  
Adrenal Glands ◽  
Tap Water ◽  
Fluid Retention ◽  
Induced Hypertension ◽  
Male Wistar Rats ◽  
Adrenalectomized Rats

1. Male Wistar rats develop systolic arterial hypertension when housed in glass metabolism cages. The present experiments were designed to investigate the involvement of the adrenal glands in this form of hypertension. 2. Rats were bilaterally adrenalectomized and maintained by either salt supplementation (1% sodium chloride solution instead of tap water to drink) or steroid replacement (corticosterone solution in the drinking water). 3. Adrenalectomized rats treated as above did not develop hypertension in response to isolation, whereas sham-operated rats (drinking either 1% saline or tap water) did. 4. Hypertension in the sham-operated rats was not accompanied by a renal retention of sodium and water. 5. It is concluded that increased adrenal activity is involved in the development of isolation-induced hypertension, but not by causing a fluid retention and hence volume expansion. The relative contributions of adrenal medullary and cortical activity remain to be determined.

scholarly journals Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Antonio Cruz ◽  
Isabel Rodríguez-Gómez ◽  
Rocío Pérez-Abud ◽  
Miguel Ángel Vargas ◽  
Rosemary Wangensteen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thyroid Hormone ◽  
Wistar Rats ◽  
Sodium Balance ◽  
Salt Loading ◽  
Blood Pressure Elevation ◽  
Hormone Levels ◽  
Induced Hypertension ◽  
Male Wistar Rats ◽  
Thyroid Hormone Levels

The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed. Four groups of male Wistar rats were treated for five weeks: control, clofibrate (240 mg/kg/day), salt (2% via drinking water), andsalt+clofibrate. Body weight, systolic blood pressure (SBP), and heart rate (HR) were recorded weekly. Finally, SBP, HR, and morphologic, metabolic, plasma, and renal variables were measured. Salt increased SBP, HR, urinary isoprostanes, NOx, ET, vasopressin and proteinuria and reduced plasma freeT4(FT4) and tissueFT4andFT3versus control rats. Clofibrate prevented the increase in SBP produced by salt administration, reduced the sodium balance, and further reduced plasma and tissue thyroid hormone levels. However, clofibrate did not modify the relative cardiac mass, NOx, urinary ET, and vasopressin of saline-loaded rats. In conclusion, chronic clofibrate administration prevented the blood pressure elevation of salt-loaded rats by decreasing sodium balance and reducing thyroid hormone levels.

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