scholarly journals Evaluation of Antihyperglycemic and Antihyperlipidemic Activity of Leaf Extracts of Breynia vitis-idaea in Alloxan Induced Diabetic Rats

2016 ◽  
Vol 8 (3) ◽  
pp. 259-263 ◽  
Author(s):  
Jagdish Chandra Nagar ◽  
Lalit Singh Chauhan
Keyword(s):  
Diabetic Rats ◽  
Leaf Extracts ◽  
Antihyperlipidemic Activity

scholarly journals Effects of methanol leaf extracts of Loranthus micranthus Linn from three host plants on some biochemical indices of diabetic rats

2018 ◽  
Vol 16 (12) ◽  
pp. 2919
Author(s):  
Uwakwe S Onoja ◽  
Innocent E Nweze ◽  
Nwachukwu Ekere ◽  
Philip F Uzor ◽  
Onyinyechi B Giginna
Keyword(s):  
Host Plants ◽  
Diabetic Rats ◽  
Leaf Extracts ◽  
Biochemical Indices

scholarly journals ARISTOLOCHIA BRACTEOLATA – ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY IN DEXAMETHASONE-INDUCED DIABETIC RAT MODEL

2017 ◽  
Vol 10 (8) ◽  
pp. 75
Author(s):  
Ganga Rajum ◽  
Hema Sundar Reddy T ◽  
Hema Sundar Reddy T
Keyword(s):  
Blood Glucose ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antihyperlipidemic Activity ◽  
Aristolochia Bracteolata

  Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

scholarly journals Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i> and <i>Peristrophe bicalyculata</i> in Alloxan-Induced Diabetic Rats

2014 ◽  
Vol 05 (04) ◽  
pp. 340-348 ◽  
Author(s):  
I. A. Iwara ◽  
G. O. Igile ◽  
I. P. Ogar ◽  
O. E. Mboso ◽  
U. P. Ujong ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Diabetic Rats ◽  
Leaf Extracts ◽  
Peristrophe Bicalyculata

scholarly journals ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF JATROPHA GOSSYPIFOLIA METHANOLIC EXTRACT IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETIC RATS

2017 ◽  
Vol 10 (11) ◽  
pp. 326 ◽  
Author(s):  
Issac Praveen Kumar ◽  
Ishan Malhotra ◽  
Sujatha Sundaresan ◽  
Alwin Dev
Keyword(s):  
Liver Function ◽  
Glycogen Content ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Liver Glycogen ◽  
Treated Group ◽  
Diabetic Rats ◽  
Antihyperlipidemic Activity ◽  
Jatropha Gossypifolia

  Objective: The objective of the present study is to explore the antihyperglycemic and antihyperlipidemic activities of Jatropha gossypifolia methanolic extract (ME) in streptozotocin (STZ)-nicotinamide (NIC) induced diabetic model.Methods: Type II diabetes was induced by a single dose of NIC (110 mg/kg) and STZ (50 mg/kg b.w.) intraperitoneally. The diabetic animals were treated with ME (50 mg/kg and 100 mg/kg b.w.) of J. gossypifolia. At the end of experimental period, the effect of the ME on creatinine level, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very LDL (VLDL) were analyzed. Liver function parameters such as glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) were analyzed and liver glycogen content was estimated spectrophotometrically. After scarification of animals, the liver was collected and subjected to histopathology analysis. Glycogen content was estimated spectrophotometrically.Results: The ME treated diabetic rats showed a significant increase in HDL level and a decrease in creatinine, TG, TC, and VLDL levels. The treated group showed a significant decrease in liver function parameters such as GOT and GPT levels and significantly increased the liver glycogen content.Conclusion: These findings demonstrate that ME possess antihyperglycemic and antihyperlipidemic activity against STZ - NIC induced diabetic rats.

scholarly journals Anti-diabetic analysis and insulin expression study of a wild leafy vegetable Acalypha alnifolia Klein ex wild. on streptozotocin-induced diabetic rats

2015 ◽  
Vol 10 (2) ◽  
pp. 461
Author(s):  
Ponnusamy Revathi ◽  
Thangaraj Parimelazhagan
Keyword(s):  
Plasma Lipids ◽  
Lipid Level ◽  
Insulin Level ◽  
Therapeutic Benefit ◽  
Diabetic Rats ◽  
Acetone Extract ◽  
Leaf Extracts ◽  
Beta Cell Destruction ◽  
Plasma Enzymes ◽  
Insulin Expression

<p>Assessing the antidiabetic potential of <em>Acalypha alnifolia</em> is the main objective of the present study. Two doses of leaf extracts were treated with streptozotocin-induced diabetic rats for 21 days. The glucose level, insulin level, plasma lipids, total protein, electrolytes and plasma enzymes were monitored. The acetone extract of 400 mg/kg had potentiated to diminish the glucose and lipid level as well as other diabetic complications. Internal structures of pancreas were studied by histopathological sections and insulin expression was also observed by immunohistochemical study. Though the extracts having good antioxidant capability it might have to reduce the beta cell destruction or helps to repair it. The result of the toxicity analysis, histopathology and insulin expression supports the acetone extract. The present study attesting the antidiabetic properties of<em> A. alnifolia</em> hence this plant would be focused and taken for cultivation leads to add in human diet for getting therapeutic benefit.   </p><p> </p>

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