scholarly journals Cardiovascular Disease Risk Factors among Non-Alcoholic Fatty Liver Disease Patients at Makkah, Kingdom of Saudi Arabia

2016 ◽  
Vol 8 (11) ◽  
pp. 45
Author(s):  
Ahmed Faisal ◽  
Mahmoud Elshahat ◽  
Reda Goweda ◽  
Arij Alzaidi ◽  
Bashaer Aldhawani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Saudi Arabia ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Kingdom Of Saudi Arabia ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

<p><strong>BACKGROUND:</strong> Non-alcoholic fatty liver disease (NAFLD) is one of the major health problems which is characterized by excessive fat accumulation in the liver. Worldwide, NAFLD has a reported prevalence of 6 to 35 percent in the general population. The prevalence of NAFLD has increased as more patients develop a sedentary lifestyle, metabolic syndrome, and obesity.</p><p><strong>AIM &amp; OBJECTIVES:</strong> To study cardiovascular disease risk factors among NAFLD patients aiming to reduce morbidity and mortality.</p><p><strong>METHODOLOGY:</strong> This was a cross sectional study. Cardiovascular risk factors questionnaire including personal data, BMI, lipid profile and blood pressure was used to obtain the data from 150 patients with ultrasound diagnosed NAFLD and 150 patients with no evidence of NAFLD at Umm Al Qura University medical center, Makkah, Kingdom of Saudi Arabia.</p><p><strong>RESULTS:</strong> 54.7% out of 150 NAFLD patients were males, 91.3% were obese, 50.7% were diabetics, 28% hypertensive, 53.7% had high cholesterol level, 52.7 % had high triglycerides and 64.6% had high LDL level. Results showed significant high prevalence of most of CVD risk factors among NAFD patients in comparison to age matched group of patients without NAFLD.</p><p><strong>CONCLUSION:</strong> NAFLD patients have a high risk of cardiovascular diseases more than non NAFLD.<strong></strong></p>

Comorbidity of non-alcoholic fatty liver disease and cardiovascular disease: focus on ademetionine and ursodeoxycholic acid

2021 ◽  
Vol 1 (29) ◽  
pp. 13-20
Author(s):  
O. A. Polyakova ◽  
O. D. Ostroumova ◽  
G. P. Kovaleva ◽  
E. E. Pavleeva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Ursodeoxycholic Acid ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Medical Needs ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

Changes in the nature of the interaction of risk factors and global aging of the population have led to a rapid increase in patients with combined pathology, elevated to the rank of a new non-infectious epidemic. The previously existing ‘one disease, one patient’ paradigm is losing its relevance and no longer meets medical needs, therefore patients with comorbidities need a broader approach and individualized treatment regimens, which are currently not fully defined. According to modern concepts, the coexistence of pathogenetically and pathophysiologically interrelated two or more diseases in one individual is defined by the term ‘comorbidity’. The most common comorbidity phenotype is cardiometabolic. Of particular interest is the relationship between cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD), since both diseases are highly prevalent in the population and have common metabolic risk factors (obesity, diabetes mellitus, hypertension, and dyslipidemia). In addition, there is evidence that NAFLD is an independent risk factor for CVD, which suggests not only the presence of common pathogenetic mechanisms other than metabolic pathways, but also the likelihood that treatment of liver disease can reduce the burden of CVD. In this regard, this review comprehensively analyzes the relationship between NAFLD and CVD and discusses a possible therapeutic strategy, including the use of a combination of ademetionine with ursodeoxycholic acid.

scholarly journals Relationship Between BMI Degree and Non-Alcoholic Fatty Liver Disease Risk Factors

2021 ◽  
Vol 3 (1) ◽  
pp. 35-41
Author(s):  
Chairunnisa Fitri Marpaung ◽  
Gontar Alamsyah Siregar ◽  
Ilhamd
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Risk ◽  
Clinical Chemistry ◽  
Overweight And Obesity ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: Obesity is a major risk factor for cardiovascular disease, type 2 diabetes, high blood pressure, sleep apnea, psychological issues, some musculoskeletal conditions, and some cancers. The aim of the study to evaluate the correlation between BMI and risk factor of non-alcoholic fatty liver disease (NAFLD). Method: The research was conducted cross-sectionally in NAFLD patients who were treated at RSUP H Adam Malik Medan and got approval from the Ethics Commission for Health Research. Sample research is NAFLD patients who are taken in consecutive sampling that meets the criteria of inclusion and exclusion.  Body mass index (BMI) is obtained by dividing a person's weight in kilograms by their height in square meters, define obesity (OB) if BMI  >  25,  overweight  (OW) BMI  23-24.9, and normoweight (NW) BMI 18.5-22.9. Diagnose NAFLD by performing ultrasound examination, resistin and adiponectin examination with ELISA (Sandwich Immunoassay), liver function according to IFCC (International Federation of Clinical Chemistry), and albumin checked by BCG method. Result: There were 67 patients (NM=32, OW=15, OB=20) NAFLD with an average age of 42.1± 11.9 years,  Comparison of NAFLD risk factors in normoweight, overweight, and obesity, showing very significant results (all p<0.001). There is a very significant correlation between BMI and all NAFLD risk factors (all p<0.001). Conclusion: There are very significant correlates between BMI and all inflammatory factors of NAFLD.

scholarly journals Early life programming and the risk of non-alcoholic fatty liver disease

2017 ◽  
Vol 8 (3) ◽  
pp. 263-272 ◽  
Author(s):  
C. Lynch ◽  
C. S. Chan ◽  
A. J. Drake
Keyword(s):  
Cardiovascular Disease ◽  
Liver Disease ◽  
Animal Models ◽  
Fatty Liver ◽  
Early Life ◽  
Fatty Liver Disease ◽  
Disease Risk ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, type 2 diabetes and cardiovascular disease and can be considered the hepatic manifestation of the metabolic syndrome. NAFLD represents a spectrum of disease, from the relatively benign simple steatosis to the more serious non-alcoholic steatohepatitis, which can progress to liver cirrhosis, hepatocellular carcinoma and end-stage liver failure, necessitating liver transplantation. Although the increasing prevalence of NAFLD in developed countries has substantial implications for public health, many of the precise mechanisms accounting for the development and progression of NAFLD are unclear. The environment in early life is an important determinant of cardiovascular disease risk in later life and studies suggest this also extends to NAFLD. Here we review data from animal models and human studies which suggest that fetal and early life exposure to maternal under- and overnutrition, excess glucocorticoids and environmental pollutants may confer an increased susceptibility to NAFLD development and progression in offspring and that such effects may be sex-specific. We also consider studies aimed at identifying potential dietary and pharmacological interventions aimed at reducing this risk. We suggest that further human epidemiological studies are needed to ensure that data from animal models are relevant to human health.

scholarly journals Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors

2019 ◽  
Author(s):  
Jake P. Mann ◽  
Paul Carter ◽  
Matthew J. Armstrong ◽  
Hesham K Abdelaziz ◽  
Hardeep Uppal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Hospitalised Patients ◽  
All Cause Mortality ◽  
Alcoholic Fatty Liver Disease

AbstractBackgroundNon-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD). Most of the data on liver-related mortality in NAFLD derives from specialist liver centres. We aimed to assess mortality in NAFLD when adjusting for CVD in a ‘real world’ cohort of inpatients.MethodsRetrospective study of hospitalised patients with 14-years follow-up. NAFL (non-alcoholi c fatty liver), non-alcoholic steatohepatitis (NASH), and NAFLD-cirrhosis groups were defined by ICD-10 codes using ACALM methodology. Cases were age-/sex-matched 1:10 with non-NAFLD hospitalised patients from the ACALM registry. All-cause mortality was compared between groups using cox regression adjusted for CVD and metabolic syndrome risk factors.ResultsWe identified 1238 patients with NAFL, 105 with NASH and 1235 with NAFLD-cirrhosis. There was an increasing burden of cardiovascular disease with progression from NAFL to NASH to cirrhosis. After adjustment for demographics, metabolic syndrome components and cardiovascular disease, patients with NAFL, NASH, and cirrhosis all had increased all-cause mortality (HR 1.3 (CI 1.1-1.5), HR 1.5 (CI 1.0-2.3) and HR 3.5 (CI 3.3-3.9), respectively). Hepatic decompensation (NAFL HR 8.0 (CI 6.1-10.4), NASH HR 6.5 (2.7-15.4) and cirrhosis HR 85.8 (CI 72-104)), and hepatocellular carcinoma were increased in all NAFLD groups.ConclusionThere is a high burden of cardiovascular disease in NAFLD-cirrhosis patients. From a large “real-life” non-specialist registry of hospitalized patients, NAFLD patients have increased overall mortality and rate of liver-related complications compared to controls after adjusting for cardiovascular disease.

Awareness of adult population toward non-alcoholic fatty liver disease in Riyadh, Saudi Arabia

2020 ◽  
pp. 1938-1944
Author(s):  
Alhumaidi Alsubaie ◽  
Saeed Mohammad ◽  
Abdulkarim Alqarni ◽  
Abdulkareem Alosaimi ◽  
Mutaz Alenizi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Adult Population ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
Sign in / Sign up

Export Citation Format

Share Document