scholarly journals The Effect of Hemoglobin Correction by Blood Transfusion on Pregnancy Outcomes in Minor and Intermedia Thalassemia Patients: A Single-Blind Controlled Randomized Clinical Trial

2016 ◽  
Vol 9 (4) ◽  
pp. 257
Author(s):  
Mahin Najafian ◽  
Ahmad Ahmadzadeh ◽  
Mojgan Barati ◽  
Mahin Bahadori ◽  
Zeinab Shajirat
Keyword(s):  
Clinical Trial ◽  
Birth Weight ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Intervention Group ◽  
Control Group ◽  
Thalassemia Minor ◽  
Maternal And Neonatal Outcomes ◽  
Nicu Admission ◽  
Single Blind

<p>To the best of our knowledge, there is no prospective trial study assessing the management of β-thalassemia by blood transfusion in pregnancy. The aim of this study was to investigate the effect of blood transfusion on maternal and neonatal outcomes in pregnant patients with beta thalassemia minor and intermedia. We did this randomized, single –blind, controlled clinical trial on 36 pregnant women with β thalassemia minor and intermedia at two tertiary hospitals of Imam Khomeini and Shafa in Ahvaz, Iran from January 2016 to July 2016. Patients were randomly assigned to receive either packed cell or not (control group) during pregnancy (ratio 1:1). The main outcomes of interest transfusion times, abortion, preterm delivery, type of delivery (cesarean or vaginal), stillbirth, birth weight, low birth weight, very low birth weight, small for gestational age, low Apgar score (≤7) at 1 and 5 minutes, oligohydramnios, fetal anomalies , and NICU admission. The median of blood transfusion in intervention group during pregnancy was two blood units. The cesarean section rate did not significantly differ between the intervention and control groups (72.2% and 44.4%, respectively, P=0.2). Two infants in intervention group experienced with LBW, one with SGA, one with low Apgar score, two with oligohydramnios, and one with NICU admission, while none in control group experienced these complications. The mean birth weight of infants in intervention group was significantly lower than control group (P value 0.002). The comparison between two groups showed that the adverse maternal and neonatal outcomes, especially low birth weight and preterm delivery were higher in intervention group.</p>

scholarly journals Effect of Oral Erythropoietin in Prevention of Anemia of Prematurity

2018 ◽  
Vol 41 (2) ◽  
pp. 101-109
Author(s):  
Md Jamshed Alam ◽  
Md Kamrul Ahsan Khan ◽  
Nazmun Nahar ◽  
Sanjoy Kumer Dey ◽  
Md A Mannan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Breast Milk ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Control Group ◽  
Group Iii ◽  
Anemia Of Prematurity ◽  
The Mean ◽  
Group Ii

Introduction: Anemia of prematurity (AOP) is a common problem of very low birth weight babies. Blood transfusion is a necessity when it occurs in moderate to severe form putting the child in to the risk of transfusion related complications. Erythropoietin, a potent stimulator of hemopoesis is available in breast milk in good amount and absorbed intact under physiologic condition. In this background oral recombinant human erythropoietin (rhEPO) can be a useful alternative to its subcutaneous administration in prevention of AOP.Objective: To evaluate the efficacy of oral rhEPO in the prevention of AOP in very low birth weight (VLBW) neonates.Methods: This randomized controlled study conducted in the NICU of BSMMU over one year. Total 60 preterm (<34 weeks)VLBW (<1500g) infants were enrolled and randomly divided into Control (group-I), Oral (group-II) and Subcutaneous (group III). Experimental groups (group-II & group-III) received rhEPO 400 IU/Kg, 3 times weekly in oral and subcutaneous (S/C) route respectively and continued for 2 weeks (Total 6 doses). Therapy was initiated 14 days after birth when the baby achieved oral feeding of at least 50 ml/kg/day of breast milk. All infants received oral iron and folic acid supplementation up to 12 weeks of postnatal age. Transfusion data were recorded. Anthropometric and hematological assessments were done at 2, 4, 6 and 12 weeks of age.Results: Baseline clinical characteristics and hematological values were almost similar in all groups. Mean hemoglobin were 11.34±0.68gm/dl, 11.88±0.54gm/dl& 12.12±1.32 gm/dl, the mean hematocrit were 34.11±2.03%, 35.66±1.65% & 36.38±3.97% and the mean reticulocyte were 7.56±2.48%, 9.85±1.50% & 9.22±3.11% in the control, oral and subcutaneous group respectively and the differences are statistically significant (p<0.05).Weight gain was higher in the intervention group at 6 and 12 weeks follow up than the control group(p<0.05).Only 2 (5.25%) infants, one in each of the intervention groups required blood transfusion, compared to 6 (31.5%) infants in control group (p<0.01).Conclusion: Oral EPO is as good as subcutaneous use of EPO in stimulating erythropoesis, maintaining HCT and Hb at high level and is safe in preterm baby.Bangladesh J Child Health 2017; VOL 41 (2) :101-109

scholarly journals Acupuncture for Olfactory Dysfunction in Infected COVID-19 Patients: Study Protocol for a Single Blind, Randomized, Sham-Controlled Clinical Trial

2021 ◽  
Author(s):  
Linda LD Zhong ◽  
Chi-Fung CHOY ◽  
Hung-Wai CHO ◽  
Yi-Ping WONG ◽  
Alan Yat-Lun WONG ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Sham Acupuncture ◽  
Olfactory Dysfunction ◽  
Secondary Outcome ◽  
Control Group ◽  
Common Symptom ◽  
Real Acupuncture ◽  
Single Blind

Abstract Background: Olfactory dysfunction (OD) was recognized as one of common symptom of COVID-19. OD, defined as the reduced or distorted ability to smell during sniffing (orthonasal olfaction) and may represent one of early symptoms in the clinical course of COVID-19 infection. A large online questionnaire-based survey found that some of post COVID-19 patients showed no improvement at one month after they were discharged from hospital. Therefore, this clinical trial is designed to explore the efficacy of acupuncture for OD in infected COVID-19 patients and to determine whether acupuncture could have benefits than sham acupuncture for OD in post- COVID-19 patients.Methods: This is a single blind, randomized controlled, cross over trial. We plan to recruit forty post-COVID-19 patients who are presenting with smell loss or smell distortions more than one month. Qualified patients will be randomly allocated into the intervention group (real acupuncture) or the control group (sham acupuncture) in a 1:1 ratio. Each patient will receive 8 sessions of treatment over 4 week (Cycle 1), and 2-week follow-up. After the follow-up, the control group will be conducted with real acupuncture for another 4 weeks (Cycle 2), and the real acupuncture group will be conducted with the 4-week sham acupuncture. The primary outcomes are the scores change on the questionnaire of olfactory functioning and olfaction related quality of life at weeks 6, 8, 12 and 14 from the baseline. Secondary outcome is the change on the Olfactory Test score at the week 6 and 12 from the baseline measured by using the Traditional Chinese version of the University of Pennsylvania Smell Identification Test (UPSIT-TC).Discussion: The results of this trial will help to determine the effectiveness of acupuncture for OD in post-COVID-19 Patients. This may provide a new treatment option for patients.Trial registration: ClinicalTrials.gov, NCT04959747, Registered on July 13, 2021.

scholarly journals Tactile-kinesthetic stimulation to gain weight and reduce the length of stay care for premature baby at public hospitals of Semarang, Indonesia

2019 ◽  
Vol 3 (1) ◽  
pp. 25
Author(s):  
Freya Nazera Iskandar ◽  
Ari Suwondo ◽  
Bedjo Santoso
Keyword(s):  
Birth Weight ◽  
Length Of Stay ◽  
Low Birth Weight ◽  
Intervention Group ◽  
Premature Baby ◽  
Kangaroo Mother Care ◽  
Public Hospitals ◽  
Control Group ◽  
Hospital Unit ◽  
Premature Babies

Background: Premature babies are susceptible to a variety of health problems in early of their lives, thus, management of premature care should be designed to optimize the growth and development, with no more cost extension. The management of premature care by non-pharmacological treatments becomes popular nowadays, and applied in the hospital unit care, including the Tactile-Kinesthetic Stimulation (TKS) and Kangaroo Mother Care (KMC).Aims: This study is to present the effect of Tactile-Kinesthetic Stimulation (TKS) on weight gain and reduction length of stay care for premature babies, and to compare the results with the standard Kangaroo Mother Care (KMC) given at the hospital care unit.Methods: The study used a quasi-experimental design with pretest-posttest with a control group. A total of 32 premature babies was equally divided to a control group given a standard KMC procedure and an intervention group receiving the TKS. Sampling was done using a consecutive sampling method where the low birth weight infants were selected from two public hospitals in Semarang of Indonesia, with consent from the parents. Data was then analyzed by a repeated measure ANOVA, general linear model and Mann-Whitney test to find the significant mean difference at p value less than 0.05.Results: The data shows that the babies’ weight significantly increased day by day only if the premature neonates received Tactile-Kinesthetic Stimulation, gained 148.75 gram only 3 days after the initial measurement. However, from this study we noted that the premature babies’ weight at the control group provided only with Kangaroo Mother Care slightly decreased at 35.69 gram at the third day of observation. In average, premature babies receiving TKS need only 3 days before return home, while if receiving the standard KMC the preterm babies required 5 days in the hospital care.Conclusion: Not only effective to gain the weight, giving Tactile-Kinesthetic Stimulation to the low birth weight baby shorter the length of stay in the hospital unit care. It suggests that the TKS intervention will provide good result in maintaining the weight of the low birth weight baby and will reduce the costs of staying in the hospital unit care. Keywords: Tactile-Kinesthetic Stimulation, Kangaroo Mother Care, Low birth weight, Length of stay care, Premature baby.

scholarly journals Renal function in the third year among very low birth weight infants fed by supplemental proteins

2020 ◽  
Author(s):  
Arash Bordbar ◽  
Azade Noroozi Vahid ◽  
Mandana Kashaki
Keyword(s):  
Renal Function ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Intervention Group ◽  
Protein Supplementation ◽  
Control Group ◽  
P Value ◽  
Mean Values ◽  
Vlbw Infants

Very Low Birth Weight (VLBW) infants have higher nutritional needs than term infants. Energy and protein are two important factors influencing their growth. Breastfeeding is not enough to meet VLBW infants’ needs, for this reason, complementary protein is required by them. Hence, the present study aimed at investigation of renal function among VLBW infants receiving complementary proteins. The study was conducted on two groups of intervention and control (n= 18 in each group) (Case study: VLBW infants born in Akbarabadi hospital of Tehran in 2014 2015). The intervention group includes 3-year-old children who weighting less than 1200 grams at birth and have received protein supplementation at the course of NICU hospitalization, protein was added to maternal milk when the amount of milk reaches to 100 cc/kg/day, at this time parenteral nutrition was discontinued and the volume of feeding was increased 20cc/kg/day until reached to 150-180cc/kg/day. We also added the fortifier to breast milk at this time. The fortification and the protein supplementation were stopped when the weight of the baby reached to 1500 grams. The control group was fed similar to the intervention group but had received no complementary protein . The renal function was evaluated by measuring such criteria as BUN, Cr, ALB and U/A. After data collection, a statistical analysis was performed using SPSS software Ver. 22. Following to BUN evaluation, a significant correlation was seen between BUN and received protein (p-value=0.010). However, there was no significant correlation between Cr and received protein as well as mean values of the two groups (p-value=0.0766). Similarly, an insignificant correlation was found between the two groups following to investigation of ALB (p-value=0/257), while the mean values of the two groups were similar. The both groups were also equal in U/A. The complementary protein increased the BUN with no effect on Cr, ALB and U/A, providing no impact on renal function. Therefore, complementary protein intake made no conflict in renal function.

scholarly journals EFFECTIVENESS OF POLYETHYLENE SKIN WRAP IN PREVENTION OF HYPOTHERMIA IN PRETERM AND LOW BIRTH WEIGHT NEONATES

2021 ◽  
Vol 71 (3) ◽  
pp. 810-13
Author(s):  
Goher Ali Khan ◽  
Usman Riaz ◽  
Sara Iqbal ◽  
Tariq Aziz Qureshi ◽  
Hina Kanwal Shafaat
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Intervention Group ◽  
Military Hospital ◽  
Control Group ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Neonatal Hypothermia

Objective: To establish the effectiveness of polyethylene skin wrap in prevention of neonatal hypothermia in preterm and low birth weight neonates. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Pediatrics, Combined Military Hospital Quetta, from May 2015 to Apr 2017. Methodology: A total of 176 neonates were enrolled according to the inclusion and exclusion criteria, through non-probability consecutive sampling. Eighty eight newborns were randomly distributed to each of group “A” and “B” by lottery method. The intervention group “A” infants were wrapped in a polyethylene skin wrap from shoulders down while the control group “B” newborns were wrapped with conventional blankets. After shifting to neonatal intensive care unit, axillary temperatures were recorded with similar pediatric digital thermometers upon admission and after one hour and two hours following admission in the two groups. Results: The mean temperatures measured at one hour and two hours after admission showed significant statistical improvements in the intervention group as compared to the control group (<0.05). Conclusion: The use of polyethylene skin wrap in preterm and low birth weight neonates potentially offers a useful intervenetion in prevention of neonatal hypothermia.

Effects of the Use of Semipermeable Membranes on Fluid Loss in Low-Birth-Weight Premature Newborns

2011 ◽  
Vol 15 (2) ◽  
pp. 200-204 ◽  
Author(s):  
Eloah de Paula Pessoa Gurgel ◽  
Marcos Venícios de Oliveira Lopes ◽  
Joselany Áfio Caetano ◽  
Karla Maria Carneiro Rolim ◽  
Paulo Cesar de Almeida ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Controlled Trial ◽  
Intervention Group ◽  
Sodium Concentration ◽  
Hydration Status ◽  
Control Group ◽  
Fluid Loss ◽  
Semipermeable Membranes ◽  
Premature Newborns

Studies have shown that the application of semipermeable membranes to the skin of premature newborns (NBs) can aid in protecting the skin, reduce disturbances in fluid and electrolyte levels, and decrease neonatal mortality. The aim of this study was to verify the effect of using semipermeable membranes in low-birth-weight preterm newborns (PTNBs). A randomized controlled trial was carried out in the neonatal intensive care unit (NICU) with 42 NBs split evenly into an intervention group (IG), in which semipermeable membranes were used to cover large areas of the skin for the first 7 days of life, and a control group (CG), which received normal care. The variables investigated for the study were weight, hydration status, urinary density, glycemic control, sodium concentration, and daily hydration quota. The following variables displayed significant daily variation: weight, hydration quota, and sodium concentration. Statistically significant individual effects by day and by group were found only for sodium concentration. In the overall analysis of the intersubject effects, sodium concentration, alone, proved to be significant ( p = .055). Significant effects by group in relation to the sodium concentration were found, with the IG showing a lower average sodium concentration than the CG. Thus, the use of semipermeable membranes reduced fluid loss in premature NBs in the current study, confirming the findings of previous studies. Guidelines for practice may now be warranted.

The Effect of Three Nursing Interventions on Thermoregulation in Low Birth Weight Infants

2011 ◽  
Vol 30 (3) ◽  
pp. 160-164 ◽  
Author(s):  
Debra A. Lewis ◽  
Lynda P. Sanders ◽  
Dorothy Y. Brockopp
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Room Temperature ◽  
Delivery Room ◽  
Outcome Variable ◽  
Control Group ◽  
Nursing Interventions ◽  
Low Birth Weight Infants ◽  
Main Outcome Variable ◽  
Nicu Admission

ABSTRACTPurpose: The primary aim of this study was to evaluate the use of three nursing interventions—occlusive wrap, chemical mattress, and regulation of delivery room temperature—singly and in combination in consecutive years on thermo-regulation in six groups of low birth weight infants.Design: A quasi-experimental design was used. Prospective data were collected on 133 infants weighing <1,500 g. Interventions were tested on different groups of infants in each of three years. The control group comprised 295 infants on which retrospective chart data were available over an earlier three-year period.Sample: Infants weighing <1,500 g participated in the study.Main Outcome Variable: The main outcome variable was NICU admission temperatures of infants weighing <1,500 g. For data analysis, infants were divided into two groups: those weighing <1,000 g and those weighing between 1,000 and 1,500 g.Results: For each of the three interventions, the percentage having a normal NICU admission temperature in each intervention group exceeded the control group percentage, but the increase was not significant. Use of each intervention—occlusive wrap alone, occlusive wrap in addition to chemical mattress, and occlusive wrap in addition to chemical mattress and increased delivery room temperature—appeared to influence thermoregulation positively.

scholarly journals Perioperative booklet for orthognathic patients: A randomized controlled clinical trial

2018 ◽  
Vol 8 (12) ◽  
pp. 90 ◽  
Author(s):  
Cristina Silva Sousa ◽  
Vanessa de Brito Poveda ◽  
Ruth Natalia Teresa Turrini
Keyword(s):  
Clinical Trial ◽  
Mixed Models ◽  
Pain Treatment ◽  
Intervention Group ◽  
Self Care ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Bodyweight Loss ◽  
Single Blind ◽  
Scale Data

Objective: This study compared the effectiveness of an informational booklet on postoperative self-care, knowledge, anxiety and symptoms related to orthognathic surgery.Methods: This study is a randomized, single-blind, controlled clinical trial. This study was carried out from August 2013 to August 2015 and included 40 participants (20/group). The intervention group had routine postoperative surgeon guidance, and received a self-care booklet. Booklet information was explained by a nurse. The control group received only routine surgeon guidance. Knowledge and anxiety were compared pre- and postoperatively. Postoperative outcomes included self-care (oral hygiene, mobility and sensitivity, hydration of the lips, edema, and sleeping and breathing conditions), nutrition (eating ability and change in bodyweight), and pain (treatment required and a visual analog scale). Data were analyzed by general linear mixed models and mixed-effects models.Results: Knowledge was higher in intervention group compared to control group (p < .001). Anxiety assessment displayed no difference between groups. The intervention group had more halitosis (p = .003) and greater bodyweight loss (p = .002).Conclusions: The booklet increased knowledge of postoperative self-care, but did not lower anxiety. Halitosis and weight loss were higher in the intervention group, however, most outcomes were similar between groups.

scholarly journals Probiotic Supplementation and Its Effect on Weight and Feed tolerance in Preterm Low Birth Weight Newborns: A Clinical Trial

2017 ◽  
Vol 39 (2) ◽  
pp. 82-87
Author(s):  
Sadeka Choudhury Moni ◽  
MA Mannan ◽  
Sanjoy Kumer Dey ◽  
Arjun Chandra Dey ◽  
Debashish Saha ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Gain ◽  
Birth Weight ◽  
Breast Milk ◽  
Low Birth Weight ◽  
Hospital Stay ◽  
Neonatal Intensive Care ◽  
Control Group ◽  
Probiotic Supplementation ◽  
Expressed Breast Milk

Background: Establishment of full enteral feed is a major challenge in the care of preterm low birth weight (LBW) neonates. Probiotics are live microbial supplements that colonize preterm bowel with favourable flora, improve tolerance to feed and promotes growth of these premies.Objective: To determine the effect of probiotic supplementation on feed tolerance, postnatal weight gain, duration of hospital stay in preterm low birth weight babies.Methods : This prospective clinical trial was conducted in the Neonatal Intensive Care Unit (NICU), Bangabandhu Sheikh Mujib Medical University, (BSMMU) from February, 2012 to November, 2012. A total of 65 preterm, low birth weight ( LBW) newborns were included in this study. A multistrain probiotic suspension was given once daily to the infants in probiotic group along with expressed breast milk (EBM) through the nasogastric tube/ dropper from the first day of feed which was continued till attainment of full feed. Those in controls received only expressed breast milk. Weight, feed volume increment, features of intolerance were followed up daily. Relevant investigations were done whenever indicated.Results: The mean time to reach full enteral feed in probiotic and control group was 13.71±3.4 vs 16.53±6.13; p<0.05. But weight gain was not affected by supplementation. Hospital stay was shorter in supplemented group.Conclusion: Probiotic supplementation in preterm low birth weight babies improves feed tolerance and decreases hospital stay but does not affect weight gain.Bangladesh J Child Health 2015; VOL 39 (2) :82-87

scholarly journals A randomised comparative study of coconut oil massage for effect on weight change in low birth weight neonates

2021 ◽  
Vol 8 (9) ◽  
pp. 1575
Author(s):  
Kumari Mohini ◽  
Munna Lal Jaipal ◽  
Surender Singh Bisht ◽  
Amita Tyagi
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Comparative Study ◽  
Neonatal Intensive Care ◽  
Intervention Group ◽  
Coconut Oil ◽  
Neurological Complications ◽  
Control Group ◽  
Positive Effects

Background: Low birth weight (LBW) babies have more the risk of the neurological complications, physiological problems and mental retardation. Topical massage with natural oil is routinely practiced in India. The positive effects of massage are weight gain, improved sleep/wake pattern, decreased the stress, early discharge from the neonatal intensive care unit (NICU), improve the skin integrity and enhanced parent’s infant bonding.Methods:This prospective interventional randomised comparative study was conducted among 64 LBW babies at Paediatric department of Swami Dayanand hospital (SDH), Delhi. Out of which 31 were in intervention group and 33 were in control group.  In the intervention group, mothers were encouraged to massage their babies with 10 ml of coconut oil for 15 min, twice a day until 10 days of life. Those allocated to the control group were received care as usual. Weight and head circumference was measured at enrolment and on day 11 in both the groups.Results: Basic characteristics of neonates of intervention and control group were almost similar. Mean weight gain in intervention group was 352.26±101.05 g while it was 209.70±124.66 g in control group (p=0.0001). Similarly mean weight gain velocity was significantly higher in intervention group (32.02±19.19 g/day) as compared to control group (19.09±11.33 g/day, p=0.0001).Conclusions:The present study supports significant increase in weight gain in LBW preterm and term neonates with coconut oil massage. Coconut oil is easily available in the market and it should be recommended to LBW babies for their better weight gain.

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