Biochemical Effects Of B-Success (A Nigerian Herbal Remedy) On Liver And Heart Of Albino Rats

10.5580/2bbf ◽  
2012 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Herbal Remedy ◽  
Albino Rats ◽  
Biochemical Effects

Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats

Contraception ◽  
1992 ◽  
Vol 45 (5) ◽  
pp. 493-509 ◽  
Author(s):  
Paul Udoh ◽  
D.R. Patil ◽  
M.K. Deshpande
Keyword(s):  
Albino Rats ◽  
Biochemical Effects

scholarly journals Trigonella Foenum Graecum Extract Benefits on Hematological, Biochemical and Male Reproductive System of as a Complementary Therapy with Glimepiride in Treating Streptozotocin Induced Diabetic Rats

2019 ◽  
Vol 1 (3) ◽  
pp. 45-59
Author(s):  
Nawal A. Elghazaly ◽  
Hala H. Zaatout ◽  
Eman H. Radwan ◽  
Mohamed M. Elghazaly ◽  
Eman A. Elsheikha
Keyword(s):  
Herbal Remedy ◽  
Treatment Options ◽  
Complementary Therapy ◽  
Diabetic Rats ◽  
Herbal Remedies ◽  
Albino Rats ◽  
Oral Glucose ◽  
Research Information ◽  
Oxidative Stress Biomarkers ◽  
Conventional Drug

Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on treatment options for type 2 diabetes. Fenugreek (Trigonellafoenum graecum) seeds have been documented as a traditional plant treatment for diabetes. Soluble dietary fiber of Fenugreek significantly improved oral glucose tolerance in diabetic rats. It also exerts anti-diabetic effects mediated through the inhibition of carbohydrate digestion and absorption and the enhancement of peripheral insulin action. Most herbal remedies can interact with allopathic drugs resulting in altered activity and toxicity. At the same time, herbal remedies might produce the same kind of effects as the drug produce. Current published research information on herb-drug interactions is scanty. So, the aim of this study was to investigate the possible interaction between conventional drug used for the management of diabetes; (Glimepiride) and a traditional herbal remedy; Fenugreek aqueous extract in Streptozotocin induced diabetic male albino rats. In conclusion, combination therapy induces better hematological, biochemical effects and improves the oxidative stress biomarkers and antioxidant enzymes. Histological studies showed better results on some organ functions. The results emphasize the benefit of using the combination of Fenugreek seeds aqueous extracts as supportive complementary anti-diabetic therapy.

scholarly journals Ameliorative Effect of Administering Avocado (Persea americana) Leaf Extract on Lead Acetate Toxicity in the Brain-cerebellum of Albino Rats

2020 ◽  
pp. 29-37
Author(s):  
Ubi Essien Isaac
Keyword(s):  
Body Weight ◽  
Lead Poisoning ◽  
Lead Acetate ◽  
Leaf Extract ◽  
Herbal Remedy ◽  
Persea Americana ◽  
Control Group ◽  
Albino Rats ◽  
Histological Techniques ◽  
The Brain

Aim: To investigate whether the aqueous extract of avocado leaves can be used in alternative medicine for the remediation or treatment of lead poisoning in the brain. Study Design: Pure Experiment, using animal models. Place and Duration of Study: Department of Anatomy, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria; between January 2019 and June 2019. Methodology: Twenty albino Wistar rats including both male and female, and weighing around 155 g were randomly assigned to four groups (designated as A,B,C and D), with each group consisting of five animals. While group A served as the control, group B was administered a daily dose of 500 mg/kg body weight of avocado leaf extract, group C received 150 mg/kg body weight per day of lead acetate, and group D was given 150 mg/kg body weight per day of lead acetate and immediately followed with 500 mg/kg body weight/day of the avocado leaf extract. Treatments were given once daily through the oral route using a syringe with attached micropipette tube for 15 days, while the animals had access to water and chow ad libitum. The rats were euthanized on the 16th day by cervical dislocation and the cranial cavity was carefully exposed in order to dissect the brain and to obtain tissue samples from the cerebellum, which were then prepared for microscopic examination using routine histological techniques, with hematoxylin and eosin (H&E) stains. Results: The findings showed the extract to be ameliorative by reducing histomorphological distortions of lead acetate toxicity in the brain, and thus caused moderate regeneration of the cerebellar tissue. Conclusion: The outcome of this research therefore indicates that the avocado leaf extract has medicinal potentials and could serve as an herbal remedy in the alternative treatment of lead poisoning.

Genotoxic, hematoxic, pathological, and biochemical effects of hexane on Swiss albino rats

2000 ◽  
Vol 20 (6) ◽  
pp. 329-340 ◽  
Author(s):  
�nal Egeli ◽  
Berrin Tunca ◽  
Pinar Tuncel ◽  
M�fit Kahraman ◽  
Bet�l Sevinir ◽  
...  
Keyword(s):  
Albino Rats ◽  
Biochemical Effects
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