PRRT as an alternative method of treatment in patient with glucagonoma syndrome: A case report

2017 ◽  
Vol 6 (1) ◽  
pp. 0-0
Author(s):  
A. Popławska-Kita ◽  
A. Szyszkowska ◽  
P. Brelska ◽  
M. Kowalczuk ◽  
A. Szostek ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Tumor Size ◽  
Somatostatin Receptors ◽  
Somatostatin Analogs ◽  
Treatment Modalities ◽  
Surgical Removal ◽  
Entire Body ◽  
Regional Lymph Nodes ◽  
Necrolytic Migratory Erythema

Introduction: Glucagonoma is a rare pancreatic neuroendocrine tumor derived from alpha-cells of the islet of Langerhans. Due to oversecretion of glucagon it is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of necrolytic migratory erythema (NME), weight loss, diabetes mellitus, diarrhea, normochromic normocytic anemia, deep vein thrombosis or pulmonary embolism and neuropsychiatric disturbances. Treatment modalities include surgical removal of tumor, somatostatin analogs and peptide receptor radionuclide therapy (PRRT). Case report: We present a case of 61-year-old woman diagnosed with glucagonoma in April 2012. Initially, body-caudal pancreatomy and resection of regional lymph nodes were performed. Five months after surgery, a PET-CT scan detected pathological mass with expression of somatostatin receptors in pancreatic body and metastases to regional lymph nodes. What is more, since April 2014 the patient had complained about persistent pruritus of the entire body. At present, due to the nonsurgical pancreatic mass and metastases she is treated with somatostatin analogs and PRRT. During this therapy the pruritus had decreased and currently there is no sign of cutaneous disease. Moreover, reduction of tumor size was obtained. Conclusions: PRRT may reduce tumor size and by reducing bothersome symptoms substantially improve the quality of life in patients with SSTR-positive tumors

scholarly journals Growth hormone–secreting macroadenoma of the pituitary gland successfully treated with the radiolabeled somatostatin analog 90Y-DOTATATE: case report

2016 ◽  
Vol 125 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Joanna Waligórska-Stachura ◽  
Paweł Gut ◽  
Nadia Sawicka-Gutaj ◽  
Włodzimierz Liebert ◽  
Maria Gryczyńska ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Tumor Size ◽  
Pituitary Tumor ◽  
Somatostatin Receptors ◽  
Somatostatin Analogs ◽  
Pituitary Tumors ◽  
Somatostatin Analog ◽  
Surgical Removal ◽  
Radiolabeled Somatostatin Analog

Pituitary tumors causing acromegaly are usually macroadenomas at the time of diagnosis, and they can grow aggressively, infiltrating surrounding tissues. Difficulty in achieving complete tumor removal at surgery can lead toward a strong tendency for recurrence, making it necessary to consider a means of treatment other than those currently used such as somatostatin analogs (SSAs), growth hormone (GH) receptor antagonist, surgical removal, and radiotherapy. The purpose of this paper is to describe a patient diagnosed with an aggressive, giant GH-secreting tumor refractory to medical therapy but ultimately treated with the radiolabeled somatostatin analog 90Y-DOTATATE. A 26-year-old male with an invasive macroadenoma of the pituitary gland (5.6 × 2.5 × 3.6 cm) and biochemically confirmed acromegaly underwent 2 partial tumor resections: the first used the transsphenoidal approach and the second used the transcranial method. The patient received SSAs pre- and postoperatively. Because of the progression in pituitary tumor size, he underwent classic irradiation of the tumor (50 Gy). One and a half years later, the patient presented with clinically and biochemically active disease, and the tumor size was still 52 mm in diameter (height). Two neurosurgeons disqualified him from further surgical procedures. After confirming the presence of somatostatin receptors in the pituitary tumor by using 68Ga-DOTATATE PET/CT, we treated the patient 4 times with an SSA bound with 90Y-DOTATATE. After this treatment, the patient attained partial biochemical remission and a reduction in the tumor mass for the first time. Treatment with an SSA bound with 90Y-DOTATATE may be a promising option for some aggressive GH-secreting pituitary adenomas when other methods have failed.

scholarly journals MODERN METHODS OF DIAGNOSIS OF MAMMARY TUMOR AND TUMOR-LIKE LESIONS IN CATS

THE BULLETIN ◽  
2021 ◽  
Vol 3 (391) ◽  
pp. 33-39
Author(s):  
G.P. Dyulger ◽  
P.G. Dyulger ◽  
O. Alikhanov ◽  
E.S. Latynina ◽  
D.A. Baimukanov
Keyword(s):  
Prognostic Factors ◽  
Growth Factor ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Tumor Size ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Regional Lymph Nodes ◽  
Tnm System ◽  
High Level

The paper provides an overview of the classification and diagnosis of feline mammary tumors (FMT) in cats. The clinical stage of neoplastic process is one of the driving prognostic factors. In accordance with the WHO recommendations 1980, it is determined by the TNM system: the size of neoplasm, the state of regional lymph nodes and the presence/absence of distant metastases. The clinical stage of the disease is defined based on the obtained data during the examination, surgery and study of the postoperative material (excised tumor, the edges of the resection and regional lymph nodes). It was found that tumors larger than 3 cm have a significantly worse prognosis than tumors smaller than 3 cm. The median survival with a tumor size of less than 3 cm is 1.75 times greater (21 months versus 12 months) than with a tumor size of more than 3 cm. The most significant morphological prognostic factor is the histological type of malignant tumor and the histological gradation of tumor tissue. Among carcinomas, the most invasive are micropapillary, solid and cribriform carcinomas, the most unaggressive is carcinoma in situ. Adverse prognostic factors of mammary cancer in cats are a high Ki67 index of proliferative activity, hyperexpression of Her-2 epidermal growth factor, cyclooxygenase-2, absence or low level of expression of receptors to estrogen and/or progesterone by tumor cells (less than 10%), as well as a high level of expression by tumor cells of VEGF (vascular endothelial growth factor).

scholarly journals A Case Report of Hepatocellular Carcinoma Associated with Sarcoid Reaction in Regional Lymph Nodes

2007 ◽  
Vol 40 (3) ◽  
pp. 271-276 ◽  
Author(s):  
Soon-Myoung Kang ◽  
Akihiro Murata ◽  
Masatoshi Shibutani ◽  
Seika Tei ◽  
Shinobu Yamada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Sarcoid Reaction

Duodenal Gangliocytic Paraganglioma With Lymph Node Metastasis: A Case Report and Review of the Literature

2003 ◽  
Vol 127 (3) ◽  
pp. e139-e141 ◽  
Author(s):  
Vanitha Sundararajan ◽  
Toni M. Robinson-Smith ◽  
Andrew M. Lowy
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Metastatic Tumor ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Gangliocytic Paraganglioma ◽  
Regional Lymph Nodes ◽  
Current Case ◽  
Node Metastasis ◽  
Spindle Cells

Abstract A case of duodenal gangliocytic paraganglioma (DGP) in a 67-year-old woman is presented. The DGP arose in the second part of the duodenum. Although most of the reported cases of DGP are considered benign, in the present case, we found regional lymph nodes containing metastatic tumor. Previous reports have documented metastases containing only epithelioid cells. The current case demonstrates metastatic tumor in regional lymph nodes containing all 3 of the DGP components (spindle cells, ganglion-like cells, and epithelioid cells).

scholarly journals Kikuchi-Fujimoto disease in the regional lymph nodes with node metastasis in a patient with tongue cancer: A case report and literature review

2017 ◽  
Vol 14 (1) ◽  
pp. 257-263 ◽  
Author(s):  
Tessho Maruyama ◽  
Kazuhide Nishihara ◽  
Masanao Saio ◽  
Toshiyuki Nakasone ◽  
Fumikazu Nimura ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lymph Nodes ◽  
Tongue Cancer ◽  
Regional Lymph Nodes ◽  
Node Metastasis

scholarly journals Breast Cancer with Delayed Metastasis Only to Contralateral Regional Lymph Nodes: A Case Report and Review of the Literature

2013 ◽  
Vol 1 (1) ◽  
pp. 35-38
Author(s):  
Kwan Il Kim ◽  
Kyung Hee Lee ◽  
Tae Ryung Kim ◽  
Yong Soon Chun ◽  
Tae Hoon Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Lymph Nodes ◽  
Review Of The Literature ◽  
Regional Lymph Nodes

Septicemia and Enterocolitis Due To Shigella sonnei in a Newborn Infant

PEDIATRICS ◽  
1968 ◽  
Vol 42 (3) ◽  
pp. 529-531
Author(s):  
Ernest N. Kraybill ◽  
Guido Controni
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Newborn Infant ◽  
Large Bowel ◽  
Blood Stream ◽  
Shigella Sonnei ◽  
Shigella Dysenteriae ◽  
Regional Lymph Nodes ◽  
First Case

Shigellosis has been considered an infection usually limited to the mucosa and lumen of the large bowel with occasional involvement of regional lymph nodes. This is undoubtedly true in most cases, but well documented instances of bacteremia associated with severe systemic illnessl-5 suggest that significant blood stream invasion can occur. In the majority of cases the bacteremia was due to Shigella fiexneri or Shigella dysenteriae. Three cases of Shigella sonnei septicemia in children6-8 and one case in an adult9 have been reported. Recently, the first case report of meningitis and septicemia due to this organism in a newborn infant was published.10

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