scholarly journals Signal Detection on the Concomitant Use of Deferasirox with other Drugs and Acute Renal Failure Using Data Mining of the Japanese Adverse Drug Event Report Database and Evaluation by a Case-control Study

2016 ◽  
Vol 42 (11) ◽  
pp. 717-726 ◽  
Author(s):  
Takahito Mizuno ◽  
Takumi Umemura ◽  
Takamasa Sakai ◽  
Masahiro Fukatsu ◽  
Tetsuya Yamada ◽  
...  
Keyword(s):  
Data Mining ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Adverse Drug Event ◽  
Case Control Study ◽  
Case Control ◽  
Drug Event ◽  
Event Report ◽  
Using Data ◽  
Control Study

scholarly journals Case-control study of acute renal failure in patients with cystic fibrosis in the UK

Thorax ◽  
2008 ◽  
Vol 63 (6) ◽  
pp. 532-535 ◽  
Author(s):  
A Smyth ◽  
S Lewis ◽  
C Bertenshaw ◽  
I Choonara ◽  
J McGaw ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Risk Factor ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Long Term Treatment ◽  
The Uk ◽  
Control Study

Background:There has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A case-control study was conducted to determine the factors which are associated with an increased risk of ARF.Methods:24 cases of confirmed ARF were identified in patients with CF from 20 UK CF centres presenting between 1997 and 2004. Using the UK CF database, sex- and age-matched controls were identified. Risk factors were analysed by conditional logistic regression and Mantel-Haenszel analysis.Results:21 of the 24 patients with ARF had received an aminoglycoside at the time of their episode of ARF or in the preceding week compared with only 3 of 42 controls during the same time period (OR 81.8, 95% CI 4.7 to 1427, p<0.001). In the year before the episode of ARF, significantly more cases than controls had received gentamicin (19/24 cases vs 1/42 controls, p<0.001). The numbers receiving tobramycin were similar (9/24 cases vs 16/42 controls, p = 0.9). A known risk factor for renal impairment (prior renal disease, acute dehydration or long-term treatment with a nephrotoxic drug) was present in 18/24 cases and 7/42 controls (OR 24.0, 95% CI 3.1 to 186.6, p = 0.002).Conclusions:In patients with CF the use of an intravenous aminoglycoside is a risk factor for ARF; gentamicin is more nephrotoxic than tobramycin. Most patients who develop ARF have a risk factor which necessitates withholding aminoglycosides or more closely monitoring their use.

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