Sleep and Cognitive Function in Multiple Sclerosis

About half of patients with multiple sclerosis exhibit cognitive impairment which negatively affects their quality of life. The assessment of cognitive function in routine clinical practice is still undervalued, although various tools have been proposed for this reason. In this article, we describe the potential benefits of implementing cognitive assessment tools in routine follow -ups of MS patients. Early detection of changes in cognitive performance may provide evidence of disease activity, could unmask depression or medication side-effects and provide suitable candidates for cognitive rehabilitation. Since apathy and cognitive deficiencies are common presenting symptoms in Progressive Multifocal Leukoencephalopathy, we discuss the utility of frequent monitoring of mental status in multiple sclerosis patients at increased risk. In addition, we propose a relevant algorithm aiming to incorporate a systematic evaluation of cognitive function in every day clinical practice in multiple sclerosis.

Download Full-text

P22-4 Cognitive function and event-related potentials in patients with multiple sclerosis

Clinical Neurophysiology ◽

10.1016/s1388-2457(10)60954-6 ◽

2010 ◽

Vol 121 ◽

pp. S233-S234

Author(s):

T. Brismar ◽

L. Maurex ◽

A. Wahlin ◽

V. Nikulin ◽

F. Piehl ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Function ◽

Event Related Potentials ◽

Related Potentials

Download Full-text

Evaluation of the effects of group psychotherapy on cognitive function in patients with multiple sclerosis with cognitive dysfunction and depression

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20140144 ◽

2015 ◽

Vol 73 (2) ◽

pp. 90-95 ◽

Cited By ~ 3

Author(s):

Emine Bilgi ◽

Hasan Hüseyin Özdemir ◽

Ayhan Bingol ◽

Serpil Bulut

Keyword(s):

Multiple Sclerosis ◽

Cognitive Impairment ◽

Cognitive Function ◽

Group Psychotherapy ◽

Cognitive Dysfunction ◽

Beck Depression Inventory ◽

Neuropsychological Tests ◽

Depression Severity ◽

Group Members ◽

Repeatable Battery

Objective This study will evaluate how decreasing depression severity via group psychotherapy affects the cognitive function of patients with multiple sclerosis (MS) who are also diagnosed with depression and cognitive dysfunction. Method MS patients completed the Brief Repeatable Battery of Neuropsychological Tests and Beck Depression Inventory (BDI). The group members diagnosed with depression and cognitive dysfunction underwent group psychotherapy for 3 months. Upon completion of psychotherapy, both tests were readministered. Results Depression and cognitive dysfunction were comorbid in 15 (13.9%) of patients. Although improvement was detected at the end of the 3-month group psychotherapy intervention, it was limited to the BDI and the Paced Auditory Test. Conclusion Group psychotherapy might decrease cognitive impairment in MS patients.

Download Full-text

Cognitive Function in Hospitalized Patients with Multiple Sclerosis: A Case-Control Study

Archives of Neuroscience ◽

10.5812/ans.89632 ◽

2019 ◽

Vol 6 (3) ◽

Author(s):

Ali Reza Shafiee-Kandjani ◽

Shahrokh Amiri ◽

Zahra Mousavi ◽

Mazyar Hashemilar ◽

Salman Safikhanlou ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Function ◽

Case Control Study ◽

Case Control ◽

Hospitalized Patients ◽

Control Study

Download Full-text

1409 Electrophysiological study of cognitive function in benign Multiple Sclerosis: preliminary results

Journal of the Neurological Sciences ◽

10.1016/s0022-510x(05)81771-x ◽

2005 ◽

Vol 238 ◽

pp. S458

Keyword(s):

Multiple Sclerosis ◽

Cognitive Function ◽

Electrophysiological Study ◽

Preliminary Results ◽

Benign Multiple Sclerosis

Download Full-text

Internet-based cognitive testing in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458507077626 ◽

2007 ◽

Vol 13 (8) ◽

pp. 1011-1019 ◽

Cited By ~ 19

Author(s):

M. Younes ◽

J. Hill ◽

J. Quinless ◽

M. Kilduff ◽

B. Peng ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cognitive Function ◽

Verbal Memory ◽

Stability Index ◽

Cross Sectional Study ◽

Cognitive Testing ◽

The Internet ◽

Cross Sectional ◽

Multiple Sclerosis Patients

Cognitive impairment in multiple sclerosis is difficult to study because of the heterogeneity and variability of this disease. The gold standard for measurement of cognitive function in multiple sclerosis is a full battery of neurocognitive tests, which is time consuming and expensive. Some cognitive tests like the PASAT, a measure of working verbal memory and processing speed, have been proposed for screening and follow-up of cognitive function in clinical trials. We studied whether we could measure cognitive function in multiple sclerosis over the Internet. For this we used the Cognitive Stability Index (CSI)™, developed for persons with known or suspected primary central nervous system illness. The CSI was compared with formal neurocognitive testing (NPsych) and the PASAT in a cross-sectional study of 40 consecutive multiple sclerosis patients with subjective cognitive complaints. NPsych revealed that only 18 of the 40 patients (46%) were cognitively impaired. Although both the CSI and the PASAT were equalivalent in their specificity (86%), the CSI was significantly more sensitive than the PASAT (83% versus 28%). We conclude that the CSI, because of its availability over the Internet, has great potential as a tool for screening and follow up of cognitive function in multiple sclerosis. Multiple Sclerosis 2007; 13: 1011—1019. http://msj.sagepub.com

Download Full-text