scholarly journals Varicella-zoster meningoencephalitis and vasculitis after treatment with amenamevir to herpes zoster in the trigeminal nerve area

2021 ◽  
Vol 61 (4) ◽  
pp. 239-242
Author(s):  
Yoko Taniguchi ◽  
Yuya Kano ◽  
Taro Kitamura ◽  
Toshiyasu Miura ◽  
Kentaro Yamada
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lorenzo Stefano Pelloni ◽  
Raffaele Pelloni ◽  
Luca Borradori

Abstract Background Herpes zoster, also known as shingles, results from reactivation of the varicella-zoster virus. It commonly presents with burning pain and vesicular lesions with unilateral distribution and affects the thoracic and cervical sites in up to 60 and 20% of cases, respectively. The branches of the trigeminal nerves are affected in up to 20% of cases. Multidermatomal involvement of the trigeminal nerves has been only anecdotally described in immunocompetent subjects. Case presentation A 71-year-old previously healthy male presented with grouped vesicular and impetiginized lesions with crusts on the left half of the face of two-weeks duration. The lesions first developed on the left nasal tip and progressively worsened with unilateral appearance of vesicular lesions on the left forehead, face, ala nasi, nasal vestibulum and columella, as well as on the left side of hard and soft palate. The affected edematous erythematous areas corresponded to the distribution of the left ophthalmic (V1) and maxillary (V2) branches of the trigeminal nerve, including the infraorbital and nasopalatine nerves of the maxillary branch responsible for the oral cavity involvement. Viral DNA amplification by polymerase chain reaction confirmed the presence of Varicella zoster virus. The patient was started on oral valaciclovir with rapid recovery. Conclusions Among immunocompetent patients, herpes zoster is considered a self-limited localized infection. Our observation provides a rare but paradigmatic example of herpes zoster with involvement of both the ophthalmic and maxillary divisions of the trigeminal nerve in an immunocompetent patient. Immunocompetence status and age-specific screening should be warranted in case of atypical involvement and according to the patient’s history, while treatment with antiviral drugs should be rapidily initiated in patients at risk.


2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Naoko Shiba ◽  
Yuji Inaba ◽  
Mitsuo Motobayashi ◽  
Makoto Nishioka ◽  
Yoichiro Kawasaki ◽  
...  

Some epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS following the prolonged reactivation of VZV inside the first branch of the trigeminal nerve, exhibiting herpes zoster ophthalmicus with severe optic neuritis. Symptoms related to herpes zoster ophthalmicus and MS appeared consecutively in the 10-week period after the appearance of vesicles. This suggests that the onset of MS was triggered by some mechanism involving VZV reactivation in the first branch of the trigeminal nerve. To the best of our knowledge, this report is the first to describe a relationship between the onset of MS and herpes zoster ophthalmicus. Early diagnosis and aggressive antiviral therapy are important in cases of herpes zoster ophthalmicus to prevent the possible development of MS as well as visual impairment as sequela.


2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Deepa Gurung ◽  
Ujjwal Joshi ◽  
Bikash Chaudhary

Herpes zoster infection, commonly known as Shingles, is caused by reactivation of the Varicella-Zoster virus which may have remained latent in the dorsal root ganglia. HZI is characterized by prodromal symptoms of unilateral deep aching, burning pain followed by a maculopapular rash, vesicular eruptions, ulcers, and scab formations over the affected nerve distribution. The ophthalmic branch of the trigeminal nerve is more commonly involved in HZI than maxillary and mandibular branches; in particular, the maxillary involvement is rare. This is a case report of HZI in a 65-years-old male patient involving the maxillary division of the trigeminal nerve. This case highlights the importance of early diagnosis and prompt use of antivirals in managing orofacial HZI in dental practice.


Author(s):  
Samit Jain ◽  
Sarika Jain ◽  
Sewta Jain

Varicella zoster virus (VZV) is the causative agent for Herpes Zoster. Varicella-zoster virus reactivates from its latent state in posterior dorsal ganglion results in its spread from the ganglion to the corresponding dermatomes producing neurocutaneous signs and symptoms and can only occur in someone who has history of chickenpox (varicella). When it reactivates, it travels from the nerve body to the endings in the skin, producing blisters. Symptoms such as odontalgia, could be present during the prodromal stage. With an increase in the number of herpes zoster patients, the dentist must be familiar to the signs and symptoms of the prodromal manifestations of herpes zoster of the trigeminal nerve. This article focuses on the difficulties in management of such cases and one such case is reported here. Key Words: Varicella-zoster virus; herpes zoster; reactivate; dermatomes; prodormal stage


2020 ◽  
Vol 6 (3) ◽  
pp. 333-337
Author(s):  
O Fasina ◽  
SJ Hughes

Herpes zoster ophthalmicus is a neurocutaneous disease caused by the human alpha herpes virus Type 3 and it is characterized by reactivation of dormant varicella-zoster virus lying within the trigeminal ganglia. The objective of this study was to describe the clinical presentation and management outcome of patients with herpes zoster ophthalmicus in a tertiary health facility. This was a retrospective study of patients with herpes zoster ophthalmicus managed at the Eye Clinic of a tertiary health facility in the South-western part of Nigeria over eight years. There were 17 patients, comprising five males and the mean age at presentation was 54.9±13.7 years. Seven (41.2%) patients were seropositive for the Human Immunodeficiency Virus (HIV) while nine (52.9%) patients had corneal involvement. Fifteen (88.2%) patients had involvement of the first branch of the trigeminal nerve (V1), and one (5.9%) patient each had involvement of the second branch of the trigeminal nerve (V2) and the first two branches of the trigeminal nerve (V1 and V2). All the patients were managed with oral and topical antiviral medications. Ten patients (58.8%) developed postherpetic neuralgia. In conclusion, Herpes zoster ophthalmicus is strongly associated with HIV seropositivity and older age and a significant proportion of patients develop post-herpetic neuralgia necessitating long term management.


2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
L. Feller ◽  
R. A. G. Khammissa ◽  
J. Fourie ◽  
M. Bouckaert ◽  
J. Lemmer

Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Classical trigeminal neuralgia is a severe orofacial neuropathic pain condition characterized by unilateral, brief but recurrent, lancinating paroxysmal pain confined to the distribution of one or more of the branches of the trigeminal nerve. It may be idiopathic or causally associated with vascular compression of the trigeminal nerve root. The anticonvulsive agents, carbamazepine or oxcarbazepine, constitute the first-line treatment. Microvascular decompression or ablative procedures should be considered when pharmacotherapy is ineffective or intolerable. The aim of this short review is briefly to discuss the etiopathogenesis, clinical features, and treatment of PHN and classical trigeminal neuralgia.


2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Putri Sabila Hidayat

Abstract Background. Herpes zoster is a skin disease caused by reactivation of varicella zoster virus after its primary infection and characterized by the onset of a skin rash with a dermatomal distribution and accompanied by severe pain. The cases of herpes zoster have tended with increasing age. Objectives. This study was aimed to obtain the dermatome pattern of herpes zoster in the Dermatovenerology Polyclinic of Dr. M. Djamil Hospital Padang period 2015-2017. Method. This study was a descriptive study that was conducted in May 2018-August 2018. Simple size was 18 patients suited by inclusion criteria. Data were obtained from medical records of herpes zoster patients and presented in the frequency distribution tables. Results. The results showed that thoracic dermatome and trigeminal nerve area were most commonly involved (44.4%), within the age range of 45-64 years old (33.3%). There is no differences in events between men and women (50%). Pain is the most common major subjective complaint (88.2%) and classical grouped vesicles is the most major objective complaint (92.9%). Most patients have complications (72.2%), common complication is the neurological (38%). Conclusion. The location of dermatomes for herpes zoster patients in the the Dermatovenerology Polyclinic of Dr. M. Djamil Hospital Padang was a thoracic region of 8 patients (44.4%) and a trigeminal nerve area of ​​8 patients (44.4%). Keywords: : dermatome, herpes zoster


Author(s):  
Adam Mohamad ◽  
Wan Emelda Wan Mohamad ◽  
Mohd Najeb Soleh ◽  
Irfan Mohamad

Herpes zoster infection (HZI) occurs as a result from previous exposure to varicella zoster virus and the disease recurred at later onset of life when patient are in immunocompromised state. The manifestation can be varies and in fact can involve all parts of dermatome distribution. We present a case of HZI involving the second division of trigeminal nerve which involved danger triangle of face that resolved after one week of intravenous acyclovir.International Journal of Human and Health Sciences Vol. 02 No. 02 April’18. Page : 94-97


2021 ◽  
Vol 10 (9) ◽  
pp. 1378-1381
Author(s):  
Marcos André Killner ◽  
Fernanda Noguez Sum ◽  
Rafaela Savio Melzer ◽  
Cintia Mussi Milani

Herpes Zoster is an acute, self-limiting, viral infection caused by the reactivation of the Varicella Zoster Virus (VZV) that remains latent in the dorsal root ganglion. It commonly affects the older people and immunocompromised individuals. Diabetes patients present an increased risk for Herpes Zoster due to their impaired cell-mediated immunity.  Clinically it manifests with tingling, pruritus and painful vesicular eruptions along the affected nerve. The most commonly affected dermatomes are the thoracic and lumbar; trigeminal nerve can be involved and the ophtalmic nerve is the mostly affected. The diagnosis is based on clinical examination and laboratory confirmation. Treatment consists of antiviral therapy and is indicated to reduce acute pain symptoms, limit the spread and duration of the lesions, and prevent complications. The objective of the present study was to present a case report of Herpes Zoster involving the first and second division of the trigeminal nerve, in a 55 year old, male, diabetes patient.


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