The Comparison of Anti-Inflammatory Effect in Two Methods of Topical Dexamethasone Injection and Topical Application of Ginger Aqua-Alcoholic Extract after Removing Mandibular Wisdom Teeth

2017 ◽  
Vol 15 (9) ◽  
pp. 208-213
Author(s):  
Sahar Zandi ◽  
Seyyed Muhammadreza Alavi ◽  
Kamran Mirzaie
Keyword(s):  
Topical Application ◽  
Alcoholic Extract ◽  
Wisdom Teeth ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of diclofenac-sodium ointment (cream) in topical application.

1983 ◽  
Vol 33 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Kohei KYUKI ◽  
Tomohisa SHIBUYA ◽  
Kaito TSURUMI ◽  
Hajime FUJIMURA
Keyword(s):  
Topical Application ◽  
Diclofenac Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory Effect of Alcoholic Extract of Nigella sativa L on Bovine Fibroblast-like synoviocyte and THP-1

2018 ◽  
Vol 9 (02) ◽  
pp. 20181-20191 ◽  
Author(s):  
Dr Maghsoudi, Hossein ◽  
Samaneh Haj-allahyari
Keyword(s):  
Nigella Sativa ◽  
Pcr Analysis ◽  
Control Group ◽  
Alcoholic Extract ◽  
Iranian Traditional Medicine ◽  
Tnf Α ◽  
Radiocarpal Joint ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Due to the side effects of current therapies for osteoarthritis one of the alternative medicine is using herbal medicine such as Nigella sativa .L which in Iranian traditional medicine has been used as a treatment option. The purpose of this study is evaluating the effect of alcoholic extract of Nigella sativa (AENS) on pro-inflammatory cytokines in Bovine Fibroblast-like BFLs (BFLS) and THP-1. BFLS cells were isolated from Radiocarpal joint. After evaluating of LC50 (27 µg/mL), both cells (5x105 (cells\wel)) were incubated at 37 ° C and 5% CO2 and 90% humidity for 72 hours with AENS (6.13 μg\ml as a media LC50). One set of cells was activated for 1h with LPS for RT-PCR analysis of COX-2, INOS, IL-1β, TNF-α expression and another set of cells was activated for 24h, cells supernatant were analyzed for PGE-2 and nitrite content. The present study demonstrates that AENS reduced expression levels of COX-2, INOS, TNF-α in control group. Reduced expression of COX2 and INOS was significantly along with the reducing production of NO and PGE2.Also, AENS decreased the expression of TNF-α and iL-1β in control group. Our results showed that the anti-inflammatory effect of AENS not only has anti-inflammatory effect on the BFLS cells but also related to the THP-1 that are active in the synovial membrane.

scholarly journals Anti-inflammatory Effects of Matricaria chamomilla Extracts on BALB/c Mice Macrophages and Lymphocytes

2020 ◽  
Author(s):  
Zahra Asadi ◽  
Tooba Ghazanfari ◽  
Helia Hatami
Keyword(s):  
Cell Viability ◽  
Aqueous Extract ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Total Phenol Content ◽  
Nitric Oxide Production ◽  
Alcoholic Extract ◽  
Matricaria Chamomilla ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Matricaria chamomilla (MC) was shown to have anti-inflammatory effects. Flavonoids are major groups of MC immunomodulators. The anti-inflammatory effects of apigenin as an MC flavonoid has already been demonstrated. In this study, we aimed to report the amount of this compound by liquid chromatography-mass spectrometry (LC-MS) and measuring the total phenol content (TPC) in both the MC aqueous and alcoholic extracts. We also investigated the MC aqueous and ethanolic extracts effect on BALB/c separated macrophages and lymphocytes cell viability and macrophage nitric oxide production. Interferon-γ and interleukin-10 secretion were also measured in lymphocytes. We found that the amount of apigenin was 0.078 and 0.25 mg/g per each of dry aqueous and alcoholic extracts, respectively. Also, the total phenol content was 2.99% in aqueous and 3.95% in alcoholic extracts. BALB/c separated macrophages cell viability significantly increased when treated with the MC aqueous extract but decreased when treated by the MC alcoholic extract in the presence of lipopolysaccharide. Also, the amount of nitric oxide production by macrophages and BALB/c separated lymphocytes cell viability in treatment with aqueous and alcoholic extracts significantly decreased. Interferon-γ increased, and interleukin-10 decreased in lymphocytes treated with the MC aqueous extract, which may suggest Th1 polarization. There was no significant change in the interferon-γ level in lymphocytes when treated with the MC alcoholic extract, but the level of IL-10 increased in these cells. Altogether, besides the anti-inflammatory effect of MC extracts, we found MC aqueous extract effects as disrupting Th1/Th2 balance to Th1 upregulation. Overall, the anti-inflammatory effect of the MC alcoholic extract was higher than the MC aqueous extract.

scholarly journals ANTI-INFLAMMATORY EFFECT OF DICLOFENAC-SODIUM OINTMENT (CREAM) IN TOPICAL APPLICATION

1983 ◽  
Vol 33 (1) ◽  
pp. 121-132
Author(s):  
Kohei KYUKI ◽  
Tomohisa SHIBUYA ◽  
Kaito TSURUMI ◽  
Hajime FUJIMURA
Keyword(s):  
Topical Application ◽  
Diclofenac Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol

2021 ◽  
Vol 22 (16) ◽  
pp. 8700
Author(s):  
Wojciech Łuczaj ◽  
Anna Jastrząb ◽  
Maria do Rosário Domingues ◽  
Pedro Domingues ◽  
Elżbieta Skrzydlewska
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Uv Radiation ◽  
Topical Application ◽  
Blood Cells ◽  
Plasma Phospholipid ◽  
Uvb Radiation ◽  
Anti Inflammatory ◽  
Phospholipid Profile ◽  
Inflammatory Effect

Chronic UV radiation causes oxidative stress and inflammation of skin and blood cells. Therefore, in this study, we assessed the effects of cannabidiol (CBD), a natural phytocannabinoid with antioxidant and anti-inflammatory properties, on the phospholipid (PL) and ceramide (CER) profiles in the plasma of nude rats irradiated with UVA/UVB and treated topically with CBD. The results obtained showed that UVA/UVB radiation increased the levels of phosphatidylcholines, lysophospholipids, and eicosanoids (PGE2, TxB2), while downregulation of sphingomyelins led to an increase in CER[NS] and CER[NDS]. Topical application of CBD to the skin of control rats significantly upregulated plasma ether-linked phosphatidylethanolamines (PEo) and ceramides. However, CBD administered to rats irradiated with UVA/UVB promoted further upregulation of CER and PEo and led to significant downregulation of lysophospholipids. This was accompanied by the anti-inflammatory effect of CBD, manifested by a reduction in the levels of proinflammatory PGE2 and TxB2 and a dramatic increase in the level of anti-inflammatory LPXA4. It can therefore be suggested that topical application of CBD to the skin of rats exposed to UVA/UVB radiation prevents changes in plasma phospholipid profile resulting in a reduction of inflammation by reducing the level of LPE and LPC species and increasing antioxidant capacity due to upregulation of PEo species.

Anti-inflammatory effect of an Ayurveda polyherbal topical application and exploration of its mechanism of action

2017 ◽  
Vol 2 (06) ◽  
Author(s):  
Sitaram Ahalya ◽  
B. A. Venkatesh ◽  
R. Vijayasarathi ◽  
Tirumalapura Vijayanna Shalini
Keyword(s):  
Topical Application ◽  
Inflammatory Activity ◽  
Polyherbal Formulation ◽  
Tnf Α ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Ear Oedema ◽  
Inflammatory Effect

Background: Topical application of herbs is one of the recommended treatment modalities for Osteoarthritis (OA) in Ayurveda (Indian system of medicine). The current study intended to evaluate the anti-inflammatory effect of a polyherbal powder used as Upanaha (poultice) for OA by in vitro and in vivo techniques. Materials and Methods: The polyherbal formulation Upanaha Choornam (UC) was sourced from Vaidyaratnam Oushadhasala (P) Ltd., Thrissur, India. Changes in the secretion of TNF-α and NO and expression of Cox-2 genes were evaluated by semi quantitative PCR activity to establish anti-inflammatory action in vitro. Macrophages and connective tissue of mice were used as media for the former two experiments and only macrophages for the latter. In vivo anti–inflammatory activity was evaluated by TPA induced ear oedema in Swiss Albino mice (n=24), divided into 4 groups as Group I - saline treatment, Group II - Indomethacin treatment, and Groups III and IV treated with 30% and 60% of UC respectively. Results: In the in vitro study, UC at 1000 µg/ml and 500 µg/ml upregulated the COX-2 level by 0.08 and 0.03 folds respectively as compared to control. Release of TNF-α, and NO in LPS-induced RAW cells were significantly inhibited in a dose dependent manner. The TPA induced ear oedema significantly reduced in Groups III and IV (F=1250, p less than 0.001) Conclusion: The current study demonstrates the safety and anti-inflammatory activity of a polyherbal formulation Upanaha Choornam as a topical application. This indicates the potential of select herbs in managing degenerative conditions like OA.

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