scholarly journals Cardiorespiratory and haematologicalparameters of healthy french bulldogs

2021 ◽  
Vol 17 (3) ◽  
pp. 83-88
Author(s):  
Vinícius dos Santos Rosa ◽  
Thais Caroline da Silva Santos ◽  
Felipe Franco Nascimento ◽  
João Victor Goulart Consoni Passareli ◽  
Claudia Lizandra Ricci ◽  
...  
Keyword(s):  
Heart Rate ◽  
Platelet Count ◽  
Respiratory Rate ◽  
Plasma Protein ◽  
Normal Values ◽  
Blood Platelet ◽  
Haematological Parameters ◽  
Total Plasma ◽  
Total Plasma Protein ◽  
Blood Platelet Count

Brachycephalic dogs have a normal lower jaw and a receded upper jaw, and these dogs are predisposed to nostril stenosis, elongated palate, tracheal hypoplasia and hyperthermia due to heat stress. Giventhese characteristics, these dogs are more predisposed to respiratory and cardiovascular disorders. The popularity of brachycephalic dogsthathave a greatertendency for cardiorespiratory disorders, such as French bulldogs,has increased recently; however, studies on the cardiorespiratoryand haematological parameters in this breedare lacking. Thus, the present study sought to evaluatethe cardiorespiratory and haematological parameters of healthy French bulldogs to standardize normal values forthisbreed. Thirty-six French bulldogs wereused without predilection for age or sex, and the following parameters were evaluated: temperature (T), heart rate (HR), respiratory rate (RR), erythrogram, leukogram, total plasma protein, plasmatic fibrinogen, blood platelet count, urea, creatinine, alkaline phosphatase (AP) and alanine aminotransferase (ALT). The mean and standard deviation wereas follows: T°C (38.3±0.4), HR (111.1±27.0) beats per minute, RR (54.8±32.5) breaths per minute, erythrocyte count (7.3±1.2x106), haemoglobin (16.9±2.8 g/dL), haematocrit (48.9±7.7%), MCV (67.6±2.4fL), MCH (23.3±0.7 pg), MCHC (34.6±0.8%), RDW-CV (9.3±0.9; 9.2-12.0%), total leukocytes (11009.7±2907.3/mm3), band neutrophils (250.0±260.4/mm3), segmented neutrophils (7094.4±2307.3/mm3), eosinophils (589.7±561.3/mm3), lymphocytes (2020.8±1457.5/mm3), monocytes (987.6±528.4/mm3), total plasma protein (6.9±0.5 g/dL), plasmatic fibrinogen (274.1±96.5 mg/dL), blood platelet count (366.4±88.5/mm3), urea (35.2±12.6 mg/dL), creatinine (0.8±0.2/mg/dL), AP (49.1±25.8U/L),ALT (36.2±12.3U/L). The haematological parameters and heart rate were within the normal values for the species, but the respiratory rate values (54.8±32.5 breaths per minute)were greater than the normal averageof10 to 30 breaths per minute. We conclude thatthehaematological parameters and heart rateof healthy French bulldogs arewithin the normal limit for dogs; however, the respiratory rate is above referencevalues, reinforcing the notion that dogs of this breed, although healthy,exhibitan increasedrisk of respiratory disorders

Hypoxia alters blood coagulation during acute decompression in humans

1984 ◽  
Vol 56 (3) ◽  
pp. 666-670 ◽  
Author(s):  
H. M. O'Brodovich ◽  
M. Andrew ◽  
G. W. Gray ◽  
G. Coates
Keyword(s):  
Molecular Weight ◽  
Platelet Count ◽  
Blood Coagulation ◽  
High Molecular Weight ◽  
Plasma Protein ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Total Plasma ◽  
High Molecular Weight Kininogen ◽  
Total Plasma Protein

Acute decompression is associated with a shortening of the activated partial thromboplastin time (aPTT). This study was performed to examine whether this change in aPTT results from hypoxia or hypobaria. We exposed healthy adults on three separate occasions to 2 h of 1) hypoxic hypobaria (410 Torr, n = 5), 2) hypoxic normobaria (fractional inspired O2 tension = 0.11, n = 4), or 3) normoxic hypobaria (410 Torr breathing supplemental O2, n = 5). The aPTT shortened during hypoxic hypobaria and hypoxic normobaria (P less than 0.05) but was unchanged during normoxic hypobaria. The prothrombin and thrombin times, hematocrit, and concentrations of fibrinogen, total plasma protein, and fibrinogen-fibrin fragment E were unchanged. During hypoxic hypobaria biologic levels of prekallikrein, high-molecular-weight kininogen, and factors XII, XI, X, VII, V, and II were unchanged, but procoagulant VIII (VIII:C) increased 50% without an increase in VIII-related antigen levels (VIIIR:Ag). Fibrin monomer was not detected in any group. In one subject who became ill after 1.5 h of hypoxic normobaria aPTT shortened by 10 s; the platelet count decreased by 93,000/mm3; VIII:C increased fivefold, but VIIIR:Ag only increased three-fold. We conclude that it is the hypoxia which shortens aPTT during acute decompression to 410 Torr and speculate that it results from an increase in plasma VIII:C-like activity.

Transvascular albumin transport and protein replenishment after haemorrhage in the chronically catheterized pregnant rabbit

1996 ◽  
Vol 8 (1) ◽  
pp. 183 ◽  
Author(s):  
GJ Valenzuela ◽  
K Iacampo ◽  
HF Rauld
Keyword(s):  
Heart Rate ◽  
Plasma Protein ◽  
Heart Rate Response ◽  
Capillary Permeability ◽  
Control Period ◽  
Total Plasma ◽  
Capillary Filtration ◽  
Protein Mass ◽  
Pregnant Rabbit ◽  
Total Plasma Protein

Pregnancy is characterized by increases in both blood and interstitial volumes, but the mechanisms are unknown. To test the hypotheses that blood volume (BV) recovery after haemorrhage in pregnant (P) is faster than in nonpregnant (NP) rabbits, and that this can be explained by a higher capillary filtration, a 20% BV haemorrhage was produced in a group of 7 P and 7 NP rabbits. We determined the BV recovery (measured by 99Tc), the total plasma protein mass and the haematocrit at 10, 20, 30, 60 and 1440 min after haemorrhage. Arterial and venous pressures and heart rate were measured during a 30-min control period, during the 10 min of haemorrhage, and for the following 70 min. In a separate group of P and NP rabbits, 125I-labelled albumin was infused and blood samples were obtained at 10, 20, and 30 min. Capillary filtration was expressed as the percentage of radioactive albumin that left the intravascular space after 30 min. No differences were found in the rate of BV recovery, arterial and venous pressures, or heart rate response between P and NP animals (P > 0.1). By 24 h total plasma protein mass (TPPM) was significantly increased above baseline in the P rabbits by an average+SEM of 13 + 3.7%, but not in NP rabbits (5 + 4.5%). At 30 min, the amount of labelled albumin in the intravascular space decreased by 15.4 + 3.4% for Pv. 8.2 + 1.2% for NP rabbits (P < 0.05). There was a high correlation between TPPM recovery and BV recovery in the P (r = 0.96) and NP rabbits (r = 0.95). In conclusion, we did not find differences in the rate at which the BV recovered during pregnancy, despite the increased capillary permeability. During pregnancy, the combination of the latter with an increase in the TPPM elevation above pre-haemorrhage levels suggests a faster rate of protein mobilization.

Heart rate and blood biomarkers in Brazilian gaited horses during a standardised field gaited test

2014 ◽  
Vol 10 (2) ◽  
pp. 105-111 ◽  
Author(s):  
F.S. Silva ◽  
S.K.M. Melo ◽  
H.E.C.C.C. Manso ◽  
J.M.G. Abreu ◽  
H.C. Manso Filho
Keyword(s):  
Heart Rate ◽  
Plasma Protein ◽  
Recovery Period ◽  
Blood Parameters ◽  
Total Plasma ◽  
Blood Biomarkers ◽  
Fitness Level ◽  
Total Plasma Protein ◽  
Student’S T ◽  
Gaited Horses

There is little information about biochemical and physiological parameters in Brazilian gaited horses that could be used to develop training and performance evaluation programs. The aims of the current study were to evaluate heart rate (HR) and blood biomarkers in gaited horses during a standardised field gaited test (SGT). Sixteen horses were used to develop an SGT (10 min of warming up, 30 min of marcha gait and 15 min of recovery). Blood samples and HR were collected at rest, after warming up, after 15 (F+15) and 30 (F+30) min of marcha, and after the recovery period. The following blood parameters were measured: glucose, lactate, total plasma protein, haematocrit, urea, creatinine, glutamine, glutamate, triglycerides, total cholesterol, Ca, P, Mg, Na, Cl and K. HR measurement was carried out using an HR monitor. The results were analysed using one- and two-way ANOVA tests, and post-hoc Holm-Sidak tests. Student's t-tests were used to compare means, and the Pearson's test was utilised for correlation analyses. Glucose and lactate increased during SGT (P<0.05), and a statistically significant interaction between phase of SGT and fitness level was observed for glucose. Additionally, haematocrit, total plasma protein, urea, creatinine, triglycerides, P and K were elevated (P<0.05), and a reduction of Ca was detected during the SGT (P<0.05). HR increased from ∼47 bpm at rest to ∼140 bpm at F+15 and F+30 (P<0.05). In conclusion, the HR and energetic biomarkers were increased during the SGT. HR was under the limit variation for values considered as submaximal for aerobic exercises in gaited horses during SGT. Additionally, some degree of dehydration was observed at the end of the marcha contest. This information may be used to better understand how gaited horses expend their energy during marcha events and to help determine a horse's fitness level.

Platelet Aggregation in Rats in Relation to Hyperuricaemia Induced by Dietary Single-Cell Protein and to Protein Deficiency

1978 ◽  
Vol 39 (02) ◽  
pp. 346-359 ◽  
Author(s):  
P D Winocour ◽  
M R Turner ◽  
T G Taylor ◽  
K A Munday
Keyword(s):  
Uric Acid ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Time Lag ◽  
Blood Platelet ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Low Protein ◽  
Blood Platelet Count ◽  
Rat Platelets

SummaryA major limitation to single-cell protein (SCP) as a human food is its high nucleic acid content, the purine moiety of which is metabolised to uric acid. Rats given a Fusarium mould as a source of SCP in diets containing oxonate, a uricase inhibitor, showed elevated plasma and kidney uric acid concentrations after 21 d, which were related to the level of dietary mould. ADP-induced and thrombin-induced platelet aggregation was greater in the hyperuricaemic rats than in controls and a progressive increase in aggregation with increasing levels of dietary mould was observed. Furthermore a time-lag, exceeding the life-span of rat platelets, was observed between the development of hyperuricaemia and the increase in aggregation. A similar time-lag was observed between the lowering of the hyperuricaemia and the reduction of platelet aggregation when oxonate was removed from the diet.If human platelets react to uric acid in the same manner as rat platelets this might explain the link that has been suggested between hyperuricaemia and ischaemic heart disease. In that event diets high in nucleic acids might be contra-indicated in people at risk from ischaemic heart disease.In rats given a low protein diet (50 g casein/kg) for 21 d ADP-induced and thrombin-induced platelet aggregation and whole blood platelet count were reduced compared with control animals receiving 200 g casein/kg diet but not in rats given 90 or 130 g casein/kg diet. A study of the time course on this effect indicated that the reduction both in aggregation tendency and in whole blood platelet count occurred after 4 d of feeding the low protein diet. These values were further reduced with time.

scholarly journals Changes in IgG and total plasma protein glycomes in acute systemic inflammation

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Mislav Novokmet ◽  
Edita Lukić ◽  
Frano Vučković ◽  
Željko –Durić ◽  
Toma Keser ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Plasma Protein ◽  
Total Plasma ◽  
Total Plasma Protein

scholarly journals Methods: Blood Platelet Counts of the Golden Hamster, Cricetus auratus

Blood ◽  
1952 ◽  
Vol 7 (9) ◽  
pp. 948-949 ◽  
Author(s):  
KENNETH OTTIS ◽  
OSCAR E. TAUBER
Keyword(s):  
Platelet Count ◽  
Adult Male ◽  
Golden Hamster ◽  
Healthy Adult ◽  
Blood Platelet ◽  
Male And Female ◽  
Platelet Counts ◽  
Healthy Adult Male ◽  
Blood Platelet Count ◽  
Direct Counts

Abstract Healthy, adult male and female golden hamsters, 3 months of age, showed blood platelet count means of 688,000 ± 141,000 per cu. mm. and 742,000 ± 120,000 per cu. mm., respectively, when direct counts were made with siliconized pipets and with Rees and Ecker fluid as a diluent.

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