scholarly journals The Adenosine–Insulin Signaling Axis in the Fetoplacental Endothelial Dysfunction in Gestational Diabetes

10.5772/55627 ◽  
2013 ◽  
Author(s):  
Enrique Guzmn-Gutirrez ◽  
Pablo Arroyo ◽  
Fabin Pardo ◽  
Andrea Leiva ◽  
Luis Sobrevi
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Insulin Signaling ◽  
Signaling Axis

Abstract LB-28: The IGF/insulin signaling axis TMPRSS2:ERG and prostate cancer survival.

2013 ◽  
Author(s):  
Thomas U. Ahearn ◽  
Andreas Pettersson ◽  
Edward C. Stack ◽  
Jing Ma ◽  
Travis Gerke ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Insulin Signaling ◽  
Cancer Survival ◽  
Signaling Axis

scholarly journals Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus

2009 ◽  
Vol 160 (4) ◽  
pp. 567-578 ◽  
Author(s):  
Michelle Colomiere ◽  
Michael Permezel ◽  
Clyde Riley ◽  
Gernot Desoye ◽  
Martha Lappas
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Placental Tissue ◽  
Insulin Signaling Pathway ◽  
Obese Patients ◽  
Obese Women ◽  
Normal Controls

ObjectiveStudies in adipose tissue and skeletal muscle suggest that impaired insulin action is due to defects in the insulin signaling pathway and may play a role in the pathophysiology of insulin resistance associated with gestational diabetes mellitus (GDM) and obesity. The present study tested the hypothesis that endogenous expression levels in the human term placenta of insulin signaling components are altered in placental tissue from GDM women in comparison with normal controls and maternal obesity.Design and methodsPlacental tissue was collected from normal, diet-controlled GDM, and insulin-controlled GDM in both non-obese and obese women (n=6–7 per group). Western blotting and quantitative RT-PCR was performed to determine the level of expression in the insulin signaling pathway.ResultsThere was a significant increase in insulin receptor (IR) substrate (IRS)-1 protein expression with a concurrent decrease in IRS-2 protein expression in non-obese women with insulin-controlled GDM compared with diet-controlled GDM and normal controls. Furthermore, a decrease in both protein and mRNA expression of phosphatidyl-inositol-3-kinase (PI3-K) p85α and glucose transporter (GLUT)-4 was observed in non-obese and obese women with insulin controlled GDM compared with normal controls. When comparing non-obese to obese patients, significant decreases in mRNA expression of IR-β, PI3K p85α and GLUT-4 was found in obese patients.ConclusionOur results suggest that post receptor defects are present in the insulin signaling pathway in placenta of women with pregnancies complicated by diabetes and obesity. In addition, expression studies demonstrate post receptor alterations in insulin signaling possibly under selective maternal regulation and not fetal regulation.

Gestational diabetes and feto-placental endothelial dysfunction: Role of exosomes from human umbilical vein endothelial cells on L-arginine/NO signalling pathway

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 111
Author(s):  
Tamara Sáez ◽  
Rocío Salsoso ◽  
Carlos Sanhueza ◽  
Fabian Pardo ◽  
Andrea Leiva ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Umbilical Vein ◽  
Signalling Pathway ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Previous gestational diabetes impairs long-term endothelial function in a mouse model of complicated pregnancy

2010 ◽  
Vol 299 (3) ◽  
pp. R862-R870 ◽  
Author(s):  
Joanna L. Stanley ◽  
Sowndramalingam Sankaralingam ◽  
Philip N. Baker ◽  
Sandra T. Davidge
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Mouse Model ◽  
Endothelial Function ◽  
Fluorescence Intensity ◽  
Mean Fluorescence Intensity ◽  
Mesenteric Arteries ◽  
Superoxide Production ◽  
Increased Risk

Women who develop gestational diabetes mellitis (GDM) display endothelial dysfunction up to 1 yr after pregnancy, despite a return to normoglycemia. It is unknown whether this dysfunction was preexisting or whether GDM pregnancy leads to long-term endothelial dysfunction. A mouse model that spontaneously develops GDM ( Lepr db/+) was used to determine whether the endothelial dysfunction that develops during GDM is evident in later life. Heterozygous and wild-type (WT) controls were allowed to litter once, then age to 9–10 mo, and were compared with virgin controls. Vascular function of small mesenteric arteries was assessed using wire myography. Concentration response curves to the thromboxane A2mimetic U46619 and the endothelium-dependent vasodilator methacholine were constructed. Superoxide production and peroxynitrite formation was also measured. Mice with previous GDM displayed blood glucose concentrations similar to previously pregnant WT mice (8.0 ± 0.1 vs. 7.1 ± 0.3 mmol/l, P > 0.05). Arteries from mice with previous GDM displayed increased sensitivity to U46619 (EC50 5.2 ± 0.7 vs. 45.2 ± 1.0 nmol/l, P < 0.01) and impaired endothelium-dependent relaxation compared with WT controls (29 ± 8 vs. 58 ± 16 percent relaxation, P < 0.05). This was associated with increased superoxide production (93.3 ± 2.3 vs. 64.6 ± 1.6 mean fluorescence intensity, P < 0.001) and increased peroxynitrite formation (173.5 ± 11.0 vs. 57.4 ± 16.2 mean fluorescence intensity, P < 0.01) compared with virgin controls. In summary, endothelial dysfunction was evident in mice with previous GDM compared with previously healthy pregnant mice or virgin controls. These data suggest that GDM affects endothelial function and may contribute to an increased risk of cardiovascular disease.

Association of advanced glycation end products (AGEs) with endothelial dysfunction, oxidative stress in gestational diabetes mellitus (GDM)

2019 ◽  
Vol 40 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Sundar Krishnasamy ◽  
Barathi Rajaraman ◽  
Vidya Ravi ◽  
Rashmi Rajagopal ◽  
Arunkumar Ganeshprasad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Exogenous insulin requires MAPK activation to reverse the umbilical vein endothelial dysfunction observed in pregnant women with gestational diabetes mellitus treated with insulin

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e95
Author(s):  
Mario Subiabre ◽  
Roberto Villalobos-Labra ◽  
Luis Silva ◽  
Gonzalo Fuentes ◽  
Fernando Toledo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Umbilical Vein ◽  
Exogenous Insulin ◽  
Mapk Activation

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation

2018 ◽  
Vol 17 (1) ◽  
pp. 52-71 ◽  
Author(s):  
Susana Contreras-Duarte ◽  
Lorena Carvajal ◽  
Bárbara Fuenzalida ◽  
Claudette Cantin ◽  
Luis Sobrevia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vascular Function ◽  
Physiological Adaptation ◽  
Aortic Atherosclerosis ◽  
Plasma Total Cholesterol ◽  
Foetal Development ◽  
In Pregnancy

Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and Triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing fetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational Diabetes Mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood. Supraphysiological dyslipidaemia is also detected in GDM pregnancies. Although there are several studies showing the alteration in the maternal and neonatal lipid profile in GDM pregnancies, there are no studies addressing the effect of dyslipidaemia in the maternal and foetal vasculature. The literature reviewed suggests that dyslipidaemia in GDM pregnancy should be an additional factor contributing to worsen GDM-associated endothelial dysfunction by altering signalling pathways involving nitric oxide bioavailability and neonatal lipoproteins.

Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

2011 ◽  
Vol 9 (6) ◽  
pp. 750-762 ◽  
Author(s):  
Enrique Guzman-Gutierrez ◽  
Fernando Abarzua ◽  
Cristian Belmar ◽  
Jyh K. Nien ◽  
Marco A. Ramirez ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Functional Link
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