scholarly journals Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance

2017 ◽  
Author(s):  
Fabrizia d’Apuzzo ◽  
Ludovica Nucci ◽  
Abdolreza Jamilian ◽  
Letizia Perillo
Keyword(s):  
Clinical Relevance ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Tissue Remodeling ◽  
Periodontal Tissue ◽  
Periodontal Tissue Remodeling

scholarly journals Biomechanical Interfaces of Corticotomies on Periodontal Tissue Remodeling during Orthodontic Tooth Movement

Coatings ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Ruojing Liu ◽  
Li Huang ◽  
Xiaoyue Xiao ◽  
Yuzhe Guan ◽  
Yukun Jiang ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Tissue Remodeling ◽  
Sham Operation ◽  
Periodontal Tissue ◽  
Wnt Signal Pathway ◽  
Post Surgery ◽  
Periodontal Tissue Remodeling

Corticotomy is an effective approach in accelerating orthodontic tooth movement (OTM) in clinical treatment. Corticotomy causes regional acceleratory phenomenon (RAP) in the alveolar bone of surgical sites. However, the molecular mechanism of RAP after corticotomy remains unclear. Herein, we established a mouse model to study the biomechanical interfaces of corticotomy-assisted OTM and to investigate the histological responses and underlying cellular mechanism. A total of 144 male C57BL/6 mice were randomly assigned into four groups: corticotomy alone (Corti), sham operation (Sham), corticotomy with tooth movement (Corti + TM), and sham operation with tooth movement (Sham + TM). Nickel–titanium orthodontic springs were applied to trigger tooth movement. Mice were sacrificed on Post-Surgery Day (PSD) 3, 7, 14, 21, and 28 for radiographic, histological, immunohistochemical, and molecular biological analyses. The results reveal that corticotomy significantly promoted alveolar bone turnover and periodontal tissue remodeling. During orthodontic tooth movement, corticotomy significantly promoted osteogenic and proliferative activity, accelerated tooth movement, and eliminated root resorption by upregulating Wnt signal pathway.

scholarly journals Long Non-coding RNA FER1L4 Mediates the Autophagy of Periodontal Ligament Stem Cells Under Orthodontic Compressive Force via AKT/FOXO3 Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Yiping Huang ◽  
Hao Liu ◽  
Runzhi Guo ◽  
Yineng Han ◽  
Yuhui Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Compressive Force ◽  
Tissue Remodeling ◽  
Mechanical Force ◽  
Periodontal Tissue ◽  
Periodontal Ligament Stem Cells ◽  
Periodontal Tissue Remodeling

Orthodontic tooth movement is achieved by periodontal tissue remodeling triggered by mechanical force. It is essential to investigate the reaction of periodontal ligament stem cells (PDLSCs) for improving orthodontic therapeutic approaches. Autophagy is an endogenous defense mechanism to prevent mechanical damage of environmental change. Long non-coding RNAs (lncRNAs) are key regulators in gene regulation, but their roles are still largely uncharacterized in the reaction of PDLSCs during orthodontic tooth movement. In this study, we showed that autophagy was significantly induced in PDLSCs under compressive force, as revealed by the markers of autophagy, microtubule-associated protein light chain 3 (LC3) II/I and Beclin1, and the formation of autophagosomes. After the application of compressive force, lncRNA FER1L4 was strongly upregulated. Overexpression of FER1L4 increased the formation of autophagosome and autolysosomes in PDLSCs, while knockdown of FER1L4 reversed the autophagic activity induced by mechanical force. In mechanism, FER1L4 inhibited the phosphorylation of protein kinase B (AKT) and subsequently increased the nuclear translocation of forkhead box O3 (FOXO3) and thus mediated autophagic cascades under compressive strain. In mouse model, the expression of Lc3 as well as Fer1l4 was increased in the pressure side of periodontal ligament during tooth movement. These findings suggest a novel mechanism of autophagy regulation by lncRNA during periodontal tissue remodeling of orthodontic treatment.

scholarly journals Localization of osteopontin and osterix in periodontal tissue during orthodontic tooth movement in rats

2011 ◽  
Vol 82 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Ji-Youn Kim ◽  
Byung-In Kim ◽  
Seong-Suk Jue ◽  
Jae Hyun Park ◽  
Je-Won Shin
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Nickel Titanium ◽  
Nuclear Antigen ◽  
Periodontal Tissue ◽  
Histological Changes ◽  
Proliferating Cell ◽  
Periodontal Tissue Remodeling

Abstract Objective: To evaluate the localization of osteopontin (OPN) and osterix in periodontal tissue during experimental tooth movement with heavy force in rats. Materials and Methods: Nickel-titanium closed-coil springs were used to create a 100 g mesial force to the maxillary first molars. On days 3, 7, 10, and 14 after force application, histological changes in periodontium were examined by immunohistochemistry using proliferating cell nuclear antigen (PCNA), OPN, and osterix. Results: PCNA-positive cells were found close to the alveolar bone and cementum on both sides. OPN-positive cells were observed along the cementing line of the cementum and bone on both sides and also were visible along with newly formed fibers in the periodontal ligament on the tension side. Osterix-positive cells were strongly detected on the surface of the alveolar bone and cementum on both sides. Conclusions: During tooth movement, periodontal remodeling occurs on both sides. These results indicate that OPN and osterix may play an important role of differentiation and osteoblasts and cementoblasts matrix formation during periodontal tissue remodeling.

scholarly journals Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats

2013 ◽  
Vol 6 (10) ◽  
pp. 757-761 ◽  
Author(s):  
Jian-Hao Yang ◽  
Zheng-Chen Li ◽  
Wei-Dong Kong ◽  
Wu Zhang ◽  
Ying-Ping Jia ◽  
...  
Keyword(s):  
Tissue Remodeling ◽  
Periodontal Tissue ◽  
Orthodontic Force ◽  
Periodontal Tissue Remodeling

scholarly journals Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement

2011 ◽  
Vol 81 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Youde Liang ◽  
Yi Zhou ◽  
Tao Jiang ◽  
Zhen Zhang ◽  
Su Wang ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Periodontal Tissue

E22 Stress analysis of tooth and periodontal tissue during orthodontic tooth movement

2011 ◽  
Vol 2011 (0) ◽  
pp. 149-150
Author(s):  
Yousuke KAWAI ◽  
Yasukazu NISHI ◽  
Mamoru MURATA ◽  
Akira NAKAJIMA ◽  
Kazuyoshi HOSHINO ◽  
...  
Keyword(s):  
Stress Analysis ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Periodontal Tissue

scholarly journals Dynamics of Alloplastic Bone Grafts on an Early Stage of Corticotomy-Facilitated Orthodontic Tooth Movement in Beagle Dogs

2014 ◽  
Vol 2014 ◽  
pp. 1-13
Author(s):  
Hyung-Joo Choi ◽  
Dong-Yeol Lee ◽  
Tae-Woo Kim
Keyword(s):  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Early Stage ◽  
Orthodontic Tooth Movement ◽  
Bone Grafts ◽  
Periodontal Tissue ◽  
Histological Findings ◽  
Beagle Dogs ◽  
The Stability ◽  
Short Time

Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological findings, augmented corticotomy-facilitated orthodontic tooth movement might enhance the condition of the periodontal tissue and the stability of the outcomes of orthodontic treatment.

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