scholarly journals Retapamulin: Current Status and Future Perspectives

2021 ◽  
Vol 16 (4) ◽  
Author(s):  
Mehdi Goudarzi ◽  
Amin Khoshbayan ◽  
Fateme Taheri
Keyword(s):  
Current Status ◽  
Clinical Use ◽  
Inhibit Protein Synthesis ◽  
Resistance Development ◽  
Action Mode ◽  
The Us ◽  
Specific Manner ◽  
Resistant Strains ◽  
Resistance Rates ◽  
Financial Issues

: Retapamulin is one of the antibiotics recently developed semi-synthetically to inhibit protein synthesis in a specific manner different from other antibiotics. This pleuromutilin derivative shows magnificent anti-bacterial activity in Gram-positive pathogens, especially Staphylococcus aureus and Streptococcus pyogenes, and now it is available in ointment formulations (1%) for clinical use with negligible side effects. Despite the low potential for resistance development, antimicrobial susceptibility rates are significantly high. This is especially important when the prevalence of mupirocin-resistant strains is increasing, and the need for new alternatives is urgent. Unfortunately, due to its oxidation by cytochrome p450, this drug cannot be used systemically. However, another pleuromutilin derivative with systemic use, lefamulin, was approved in August 2019 by the US Food and Drug Administration. In addition to pharmacokinetic features, financial issues are also barriers to consider in the progress of new antimicrobials. In this review, we attempt to take a brief look at the derivatives usable in humans and explore their structures, action mode, metabolism, possible ways of resistance, resistance rates, and their clinical use to explain and highlight the valuable points of these antibiotics.

scholarly journals Antibacterial Mechanisms of Polymyxin and Bacterial Resistance

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Zhiliang Yu ◽  
Wangrong Qin ◽  
Jianxun Lin ◽  
Shisong Fang ◽  
Juanping Qiu
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistance ◽  
Structural Modification ◽  
Bacterial Resistance ◽  
Clinical Use ◽  
Resistance Development ◽  
Structure Synthesis ◽  
Resistant Strains ◽  
Almost All ◽  
Minimal Resistance

Multidrug resistance in pathogens is an increasingly significant threat for human health. Indeed, some strains are resistant to almost all currently available antibiotics, leaving very limited choices for antimicrobial clinical therapy. In many such cases, polymyxins are the last option available, although their use increases the risk of developing resistant strains. This review mainly aims to discuss advances in unraveling the mechanisms of antibacterial activity of polymyxins and bacterial tolerance together with the description of polymyxin structure, synthesis, and structural modification. These are expected to help researchers not only develop a series of new polymyxin derivatives necessary for future medical care, but also optimize the clinical use of polymyxins with minimal resistance development.

Advances In Asthma Care

2003 ◽  
Vol 1 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Chris Garvey
Keyword(s):  
Healthcare Costs ◽  
Professional Organizations ◽  
Current Status ◽  
Asthma Care ◽  
Advanced Level ◽  
Clinical Criteria ◽  
Asthma Knowledge ◽  
The Past ◽  
The Us ◽  
Examination Process

Asthma rates in the US have risen during the past 25 years, as have asthma-related morbidity and healthcare costs. Professional organizations involved in asthma care have identified the need to assure that an advanced level of asthma knowledge and skill is available to patients with asthma, their families, and insurers. This need led to development of the certification for asthma educators. The Certified Asthma Educator (AE-C) must meet specific clinical criteria and pass a standardized examination designed to evaluate knowledge and skill for providing competent asthma education and coordination. The development and current status of the Certified Asthma Educator examination process and content are discussed, as are goals of the certification

scholarly journals IMPACT OF GLOBALIZATION UNDER THE ICH GUIDELINES ON THE CONDUCT OF REPRODUCTIVE TOXICITY STUDIES-REPORT ON CURRENT STATUS IN JAPAN, EUROPE AND THE US BY QUESTIONNAIRE SURVEY

2004 ◽  
Vol 29 (3) ◽  
pp. 201-215 ◽  
Author(s):  
Hiroshi MINESHIMA ◽  
Yoshihiko ENDO ◽  
Hiroyuki OGASAWARA ◽  
Keiji NISHIGAKI ◽  
Toshiaki NUMA ◽  
...  
Keyword(s):  
Questionnaire Survey ◽  
Reproductive Toxicity ◽  
Current Status ◽  
Toxicity Studies ◽  
Ich Guidelines ◽  
The Us

scholarly journals NIH Funding for Surgeon-Scientists in the US: What Is the Current Status?

2021 ◽  
Vol 232 (3) ◽  
pp. 265-274.e2
Author(s):  
Lindsay A. Demblowski ◽  
Brad Busse ◽  
George Santangelo ◽  
Andrew M. Blakely ◽  
Patricia L. Turner ◽  
...  
Keyword(s):  
Current Status ◽  
The Us ◽  
Nih Funding

Prevention and Detection of Fungicide Resistance Development in Rhizoctonia zeae from Soybean and Corn in Nebraska

2021 ◽  
Author(s):  
Nikita Gambhir ◽  
Srikanth Kodati ◽  
Matthew Huff ◽  
Flávio Silva ◽  
Olutoyosi Ajayi-Oyetunde ◽  
...  
Keyword(s):  
Fungicide Resistance ◽  
Resistance Management ◽  
Dry Weight ◽  
Geographic Region ◽  
Population Characteristics ◽  
Current Status ◽  
In Planta ◽  
Resistance Development ◽  
Rhizoctonia Zeae

The goal of this research was to advance the foundational knowledge required to quantify and mitigate fungicide resistance in Rhizoctonia zeae, the seedling disease pathogen of soybean and corn. In vitro sensitivity to azoxystrobin, fludioxonil, sedaxane, and/or prothioconazole was determined for 91 R. zeae isolates obtained mostly from soybean and corn fields in Nebraska. Isolates were sensitive to fludioxonil, sedaxane, and prothioconazole (EC50 < 3 µg/ml) and had a positively skewed EC50 distribution. Isolates were not sensitive to azoxystrobin in vitro (EC50 > 100 µg/ml) or in planta. Application of azoxystrobin did not significantly decrease disease severity or improve total dry weight of the soybean plants (P > 0.05). The risk of resistance development in R. zeae was estimated by characterizing its population structure. Eighty-one R. zeae isolates were genotyped using six microsatellite markers. Results showed that the population has a mixed mode of reproduction and is structured according to geographic region, suggesting limited dispersal. These population characteristics suggest that R. zeae has an intermediate risk of resistance development. Overall, this research established the current status of fungicide sensitivity in R. zeae in Nebraska and estimated its risk of resistance development, which can inform fungicide resistance management for R. zeae.

scholarly journals Macrolide-resistant phenotypes of invasive streptococcus pneumoniae isolates in Serbia

2012 ◽  
Vol 64 (4) ◽  
pp. 1377-1382
Author(s):  
Ina Gajic ◽  
Natasa Opavski ◽  
Vera Mijac ◽  
L. Ranin
Keyword(s):  
Streptococcus Pneumoniae ◽  
Susceptibility Testing ◽  
Reference Laboratory ◽  
National Reference ◽  
The Past ◽  
Triple Test ◽  
Resistance To Penicillin ◽  
Resistant Strains ◽  
Resistance Rates ◽  
Susceptibility Patterns

Macrolide resistance in Streptococcus pneumoniae has emerged as an important worldwide problem over the past decade. The aim of this study was to investigate macrolide-resistant phenotypes and the antimicrobial susceptibility patterns of invasive pneumococci in Serbia. A total of 68 invasive pneumococcal strains, collected from 2009 to 2011, were sent from regional laboratories to the National Reference Laboratory. Susceptibility testing was performed using the VITEK2 system and phenotypes were determined by triple-test. Overall penicillin and erythromycin nonsusceptibility rates were 26% and 43%, respectively. Resistance rates were higher in children than in adults. Co-resistance to penicillin and erythromycin was detected in 18% strains. Resistance rates to the third generation of cephalosporins, TMP-SXT and tetracycline were 16%, 37% and 29%, respectively. All isolates were fully susceptible to vancomycin, linezolid, fluoroquinolones, telithromycin and rifampicin. Twenty-two isolates (79%) an expressed macrolide-lincosamide-streptogramin B (MLSB) resistance phenotype and M phenotype was found in 21% of macrolide resistant strains.

scholarly journals Virgo and Gravitational-Wave Computing in Europe

2020 ◽  
Vol 245 ◽  
pp. 07050
Author(s):  
Stefano Bagnasco
Keyword(s):  
Gravitational Wave ◽  
Current Status ◽  
Low Latency ◽  
Observational Period ◽  
Compact Binaries ◽  
The Third ◽  
Compact Binary ◽  
Continuous Waves ◽  
The Us ◽  
Wave Event

Advanced Virgo is an interferometer for the detection of gravitational waves at the European Gravitational Observatory in Italy. Along with the two Advanced LIGO interferometers in the US, Advanced Virgo is being used to collect data from astrophysical sources such as compact binary coalescences and is currently running the third observational period, collecting gravitational wave event candidates at a rate of more than once per week. Data from the interferometer are processed by running search pipelines for several expected signals, from coalescing compact binaries to continuous waves and burst events. Furthermore, detector characterisation studies are run. Some of the processing needs to be done with low latency, to be able to provide triggers for other observatories and make multi-messenger observations possible. Deep searches are run offline on external computing centres. Thus, data needs also to be reliably and promptly distributed from the EGO site to computer centres in Europe and the US for further analysis and archival storage. Two of the defining characteristics of Virgo computing are the heterogeneity of the activities and the need to interoperate with LIGO. A very wide array of analysis pipelines differing in scientific target, implementation details and running environment assumptions have to be allowed to run ubiquitously and uniformly on dedicated resources and, in perspective, on heterogeneous infrastructures. The current status, possible strategies and outlook of Virgo computing are discussed.

scholarly journals The current status of ultrasound practice in Kano metropolis, Nigeria

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Mohammed Sidi ◽  
Ghali Makoda Sani ◽  
Anas Ya’u ◽  
Joseph Dlama Zira ◽  
Shem Samuel Loshugno ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Infection Control ◽  
Professional Practice ◽  
Human Body ◽  
Current Status ◽  
Electronic Noise ◽  
Clinical Use ◽  
Abdominal Masses ◽  
Poor Understanding ◽  
Ultrasound Technology

Abstract Background Ultrasound has been in clinical use to image the human body for over half a century. An audit should be performed on professional practice aimed at taking corrective measures where errors are identified and improvement in the practice when errors are not detected. This study is aimed at evaluating the current status of ultrasound practice in Kano metropolis, Nigeria. Results Out of the 70 (100%) administered questionnaires, 68 (97.14%) were returned, and 64 (91.43%) were properly filled. Fifty-eight (90.6%) knew the exact meaning of ultrasound, and 34 (53%) considered ultrasound as a modality of choice for imaging and diagnosis of abdominal masses. None of the participants was exposed to advanced ultrasound technology. Only 3 (4.7%) and 5 (7.8%) of the respondents performed infection control, air reverberation pattern and electronic noise checks. Conclusion Ultrasound practitioners demonstrate good knowledge of ultrasound and its application. However, there was unavailability of advanced ultrasound equipment. There was also poor understanding and practice of quality assurance among practitioners. Ultrasound equipment might have been grossly underutilized and qualities of images produced by the equipment are not certain were optimal.

scholarly journals Current status of porcine epidemic diarrhoea (PED) in European pigs

2019 ◽  
Vol 63 (4) ◽  
pp. 465-470
Author(s):  
Marta Antas ◽  
Grzegorz Woźniakowski
Keyword(s):  
Rna Virus ◽  
Acute Diarrhoea ◽  
Current Status ◽  
Economic Losses ◽  
Porcine Epidemic Diarrhoea Virus ◽  
Diarrhoea Virus ◽  
The Us ◽  
The Usa ◽  
Suckling Piglets ◽  
Farming Industry

Abstract Porcine epidemic diarrhoea (PED) is a highly contagious and devastating enteric disease of pigs caused by porcine epidemic diarrhoea virus (PEDV), an enveloped, single-stranded RNA virus belonging to the Alphacoronavirus genus of the Coronaviridae family. The disease is clinically similar to other forms of porcine gastroenteritis. Pigs are the only known host of the disease, and the occurrence of PED in wild boars is unknown. The virus causes acute diarrhoea, vomiting, dehydration, and high mortality in suckling piglets reaching 100%. Heavy economic losses in the pig-farming industry were sustained in the USA between 2013 and 2015 when PEDV spread very quickly and resulted in epidemics. The loss in the US pig industry has been estimated at almost seven million pigs. The purpose of this review is a description of the current status of porcine epidemic diarrhoea in European pigs and the risk presented by the introduction of PEDV to Poland in comparison to the epidemics in the USA.

Sign in / Sign up

Export Citation Format

Share Document