Correlation Between Serum Cartilage Oligomeric Matrix Protein (COMP), 25-Hydroxy Vitamin D, and Disease Activity in Patients with Knee Osteoarthritis

Objectives: The objectives of the study were to evaluate changes in 25(OH) Vitamin D levels and some biochemical parameters in rheumatoid arthritis (RA) patients compared with healthy controls and assess the correlation of 25-hydroxy Vitamin D, calcium, magnesium, and disease activity. Study the effects of anti-RA drugs on these biochemical parameters and also the role of supplements calcium and 25-OH Vitamin D in RA patients. Methods: This study conducted between 60 patients for RA and 20 healthy controls according to the American College of Rheumatology standards in 2010. In this study, 25-hydroxy Vitamin D was measured using an enzyme-linked immunosorbent assay, and also some biochemical parameters were measured with a spectrophotometer (Humalyzer 2000). Results: Serum 25(OH) Vitamin D, calcium, magnesium, and albumin levels were significantly lower in RA patients compared with healthy controls. Serum alanine aminotransferase aspartate aminotransferase levels were significantly increased in RA patients compared with healthy controls. The correlation was non-significantly among 25-hydroxy Vitamin D and clinical disease activity index (CDAI), while the results showed significantly inverse correlation calcium and magnesium concentrations with CDAI. Conclusion: 25-OH Vitamin D, calcium, albumin, and magnesium deficiency appear to be widespread in patients with RA. Thus, biochemical changes in RA are reflected in the pathogenesis of RA. Furthermore, in these results, there is no relationship between Vitamin D and the disease activity, while there is a relationship between calcium and magnesium with disease activity.

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124 SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN HYALURONAN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND KERATAN SULFATE AS PREDICTORS OF INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS: DIFFERENCES BY CHRONIC KNEE SYMPTOMS

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(10)60151-3 ◽

2010 ◽

Vol 18 ◽

pp. S62-S63 ◽

Cited By ~ 11

Author(s):

Y.M. Golightly ◽

S.W. Marshall ◽

V.B. Kraus ◽

J.B. Renner ◽

A. Villaveces ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Cartilage Oligomeric Matrix Protein ◽

Matrix Protein ◽

High Sensitivity ◽

Keratan Sulfate ◽

C Reactive Protein ◽

Reactive Protein ◽

Radiographic Knee Osteoarthritis

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Vitamin D Status in Patients Operated for Primary Hyperparathyroidism: Comparison of Patients from Southern and Northern Europe

International Journal of Endocrinology ◽

10.1155/2013/164939 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Erik Nordenström ◽

Antonio Sitges-Serra ◽

Joan J. Sancho ◽

Mark Thier ◽

Martin Almquist

Keyword(s):

Vitamin D ◽

Primary Hyperparathyroidism ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Urinary Calcium ◽

Vitamin D Status ◽

Mineral Density ◽

Before And After ◽

25 Hydroxy Vitamin D ◽

One Year

Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery.Methods. We compared two cohorts of postmenopausal women from Spain(n=126)and Sweden(n=128)that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3(25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively.Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L,P<0.001), urinary calcium (7.3 versus 4.1 mmol/L,P<0.001), and heavier adenomas (620 versus 500 g,P<0.001). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery.Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.

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25-Hydroxy vitamin D levels and its relation to disease activity and cardiovascular risk factors in women with systemic lupus erythematosus

The Egyptian Rheumatologist ◽

10.1016/j.ejr.2011.07.004 ◽

2011 ◽

Vol 33 (4) ◽

pp. 195-201 ◽

Cited By ~ 5

Author(s):

Yasser Ezzat ◽

Safaa Sayed ◽

Wafaa Gaber ◽

Abeer M. Mohey ◽

Tamer Wahid Kassem

Keyword(s):

Risk Factors ◽

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Cardiovascular Risk ◽

Disease Activity ◽

Cardiovascular Risk Factors ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis

Clinical Rheumatology ◽

10.1007/s10067-004-1000-x ◽

2004 ◽

Vol 24 (3) ◽

pp. 278-284 ◽

Cited By ~ 44

Author(s):

M. Wisłowska ◽

B. Jabłońska

Keyword(s):

Rheumatoid Arthritis ◽

Knee Osteoarthritis ◽

Cartilage Oligomeric Matrix Protein ◽

Matrix Protein

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Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Journal of Medical Biochemistry ◽

10.1515/jomb-2017-0041 ◽

2018 ◽

Vol 37 (2) ◽

pp. 103-109 ◽

Cited By ~ 7

Author(s):

Arda Kiani ◽

Atefeh Abedini ◽

Ian M. Adcock ◽

Maryam Sadat Mirenayat ◽

Kimia Taghavi ◽

...

Keyword(s):

Vitamin D ◽

Serum Level ◽

Pulmonary Function ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Calcium Level ◽

Significant Negative Correlation ◽

Urine Calcium ◽

Chronic Respiratory Diseases ◽

25 Hydroxy Vitamin D

SummaryBackground:Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.Methods:Eighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.Results:A significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.Conclusions:In conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

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