Cutting Injuries in an Academic Pathology Department

2005 ◽  
Vol 129 (8) ◽  
pp. 1022-1026
Author(s):  
Bobbi S. Pritt ◽  
Brenda L. Waters
Keyword(s):  
Lymph Nodes ◽  
Mechanism Of Injury ◽  
Pathology Laboratory ◽  
Surgical Specimen ◽  
Pathology Department ◽  
Hospital Report ◽  
Time Period ◽  
Sufficient Detail ◽  
Needle Stick Injuries ◽  
Attending Physicians

Abstract Context.—Cutting injuries pose an infrequent but serious threat to anatomic pathology personnel. Although cut-resistant gloves may reduce this danger, it is imperative to recognize specific behaviors that increase the chance of an injury. Objective.—To examine the incidence of cutting injuries in an academic pathology department and the mechanisms by which such injuries occurred. Design.—Hospital Report of Event forms completed for laboratory incidents of cutting injury from March 1998 to September 2003 were evaluated. Further information regarding the incidents was obtained, when possible, by interviews with those personnel involved. Setting.—A university-based pathology laboratory was the setting for this study. On average, 505 autopsies and 29 000 surgical specimens were processed each year during the 5.5-year time period. Participants.—Pathology attending physicians, residents, dieners, and pathologists' assistants who performed autopsies and surgical specimen examinations. Results.—Eight scalpel injuries occurred during the study period. No needle-stick injuries were reported. Searching for lymph nodes and cutting firm tissue each accounted for 3 of the injuries. Only 2 of the 8 individuals were in compliance with the departmental policy regarding protective glove wear. Hospital Report of Event forms alone failed to elicit sufficient detail regarding the mechanism of injury. Conclusions.—A laboratory-based form may be necessary to supplement the hospital form, so as to obtain full details of each injury. This information may then be disseminated to all who handle blades, with the goal of preventing future cutting injuries.

scholarly journals Spectrum of histopathological lesions in the fallopian tubes

2013 ◽  
Vol 3 (5) ◽  
pp. 356-360 ◽  
Author(s):  
S Gon ◽  
A Basu ◽  
B Majumdar ◽  
TK Das ◽  
M Sengupta ◽  
...  
Keyword(s):  
Genital Tract ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Secondary Malignancies ◽  
Fallopian Tubes ◽  
Serial Sections ◽  
Pathology Laboratory ◽  
Surgical Specimen ◽  
Neoplastic Lesions ◽  
Female Genital

Background: Fallopian tubes are common surgical specimen in the pathology laboratory; still there is a lack of data to describe the frequency of various histological fi ndings. The aim and objectives of this study was to describe the various histopathological fi ndings of fallopian tubes. Materials and Methods: Two thousand fi ve hundred and seventy fi ve cases where fallopian tubes were removed either separately or along with other female genital tract organs were studied retrospectively and their histopathological fi ndings documented. Results: Ectopic pregnancy comprised maximum number of cases closely followed by salpingitis. Primary neoplastic lesions were rare as compared to secondary malignancies. Serial sections of fallopian tube and sections from representative areas are essential for a pathologist so that the diagnosis of these pathological entities is not missed. Conclusion: Though the fallopian tubes remain unremarkable in majority of the surgical pathological specimens, it must be subjected for histopathological examination to demonstrate the pathological lesions. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 356-360 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7858

scholarly journals Linking surgical specimen length and examined lymph nodes in colorectal cancer patients

2016 ◽  
Vol 42 (2) ◽  
pp. 260-265 ◽  
Author(s):  
F. Stracci ◽  
F. Bianconi ◽  
S. Leite ◽  
A. Liso ◽  
F. La Rosa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Specimen Length ◽  
Surgical Specimen ◽  
Colorectal Cancer Patients

scholarly journals Rectal cancer: a methodological approach to matching PET/MRI to histopathology

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Miriam K. Rutegård ◽  
Malin Båtsman ◽  
Lennart Blomqvist ◽  
Martin Rutegård ◽  
Jan Axelsson ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Nodes ◽  
Imaging Modality ◽  
Methodological Approach ◽  
Neoadjuvant Treatment ◽  
Rectal Adenocarcinoma ◽  
Cancer Trial ◽  
Surgical Specimen ◽  
Tumour Spread ◽  
The Impact

Abstract Purpose To enable the evaluation of locoregional disease in the on-going RECTOPET (REctal Cancer Trial on PET/MRI/CT) study; a methodology to match mesorectal imaging findings to histopathology is presented, along with initial observations. Methods FDG-PET/MRI examinations were performed in twenty-four consecutively included patients with rectal adenocarcinoma. In nine patients, of whom five received neoadjuvant treatment, a postoperative MRI of the surgical specimen was performed. The pathological cut-out was performed according to clinical routine with the addition of photo documentation of each slice of the surgical specimen, meticulously marking the location, size, and type of pathology of each mesorectal finding. This allowed matching individual nodal structures from preoperative MRI, via the specimen MRI, to histopathology. Results Preoperative MRI identified 197 mesorectal nodal structures, of which 92 (47%) could be anatomically matched to histopathology. Of the matched nodal structures identified in both MRI and histopathology, 25% were found to be malignant. These malignant structures consisted of lymph nodes (43%), tumour deposits (48%), and extramural venous invasion (9%). One hundred eleven nodal structures (55%) could not be matched anatomically. Of these, 97 (87%) were benign lymph nodes, and 14 (13%) were malignant nodal structures. Five were malignant lymph nodes, and nine were tumour deposits, all of which had a short axis diameter < 5 mm. Conclusions We designed a method able to anatomically match and study the characteristics of individual mesorectal nodal structures, enabling further research on the impact of each imaging modality. Initial observations suggest that small malignant nodal structures assessed as lymph nodes in MRI often comprise other forms of mesorectal tumour spread. Trial registration Clinical Trials Identifier:NCT03846882.

Less Than 12 Lymph Nodes in The Surgical Specimen after Neo-Adjuvant Chemo-Radiotherapy in Rectal Cancer: Five Years Survival Analysis

2020 ◽  
Vol 46 (2) ◽  
pp. e78
Author(s):  
Kapil Dev ◽  
Neha Shivran ◽  
Jaiprakash Gurawalia ◽  
Arun Pandey ◽  
Shiva Kumar ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Survival Analysis ◽  
Lymph Nodes ◽  
Surgical Specimen

scholarly journals The Story of Goldilocks and Three Twitter’s APIs: A Pilot Study on Twitter Data Sources and Disclosure

2020 ◽  
Vol 17 (3) ◽  
pp. 864
Author(s):  
Yoonsang Kim ◽  
Rachel Nordgren ◽  
Sherry Emery
Keyword(s):  
Data Sources ◽  
Twitter Data ◽  
Time Period ◽  
Sufficient Detail ◽  
Search Filters ◽  
Research Findings ◽  
Application Programming ◽  
Data Source ◽  
Programming Interfaces ◽  
Over Time

Public health and social science increasingly use Twitter for behavioral and marketing surveillance. However, few studies provide sufficient detail about Twitter data collection to allow either direct comparisons between studies or to support replication. The three primary application programming interfaces (API) of Twitter data sources are Streaming, Search, and Firehose. To date, no clear guidance exists about the advantages and limitations of each API, or about the comparability of the amount, content, and user accounts of retrieved tweets from each API. Such information is crucial to the validity, interpretation, and replicability of research findings. This study examines whether tweets collected using the same search filters over the same time period, but calling different APIs, would retrieve comparable datasets. We collected tweets about anti-smoking, e-cigarettes, and tobacco using the aforementioned APIs. The retrieved tweets largely overlapped between three APIs, but each also retrieved unique tweets, and the extent of overlap varied over time and by topic, resulting in different trends and potentially supporting diverging inferences. Researchers need to understand how different data sources can influence both the amount, content, and user accounts of data they retrieve from social media, in order to assess the implications of their choice of data source.

Endoscopic Ultrasound Features Associated with Malignancy and Aggressiveness of Nonhypovascular Solid Pancreatic Lesions: Results from a Prospective Observational Study

2019 ◽  
Author(s):  
Stefano Francesco Crinó ◽  
Alessandro Brandolese ◽  
Filippo Vieceli ◽  
Salvatore Paiella ◽  
Maria Cristina Conti Bellocchi ◽  
...  
Keyword(s):  
Observational Study ◽  
Lymph Nodes ◽  
Endoscopic Ultrasound ◽  
Prospective Observational Study ◽  
Distant Metastases ◽  
Cross Sectional ◽  
Surgical Specimen ◽  
Contrast Enhanced ◽  
Cross Sectional Imaging ◽  
Tissue Acquisition

Abstract Background and Study Aims On contrast-enhanced imaging studies, nonhypovascular (i. e., isovascular and hypervascular) patterns can be observed in solid pancreatic lesions (SPLs) of different nature, prognosis, and management. We aimed to identify endoscopic ultrasound (EUS) features of nonhypovascular SPLs associated with malignancy/aggressiveness. The secondary aims were EUS tissue acquisition (EUS-TA) outcome and safety in this setting of patients. Patients and Methods This prospective observational study included patients with nonhypovascular SPLs detected on cross-sectional imaging and referred for EUS-TA. Lesion features (size, site, margins, echotexture, vascular pattern, and upstream dilation of the main pancreatic duct) were recorded. Malignancy/aggressiveness was determined by evidence of carcinoma at biopsy/surgical pathology, signs of aggressiveness (perineural invasion, lymphovascular invasion, and/or microscopic tumor extension/infiltration or evidence of metastatic lymph nodes) in the surgical specimen, radiologic detection of lymph nodes or distant metastases, and/or tumor growth > 5 mm/6 months. Uni- and multivariate analyses were performed to assess the primary aim. Results A total of 154 patients with 161 SPLs were enrolled. 40 (24.8 %) lesions were defined as malignant/aggressive. Irregular margins and size > 20 mm were independent factors associated with malignancy/aggressiveness (p < 0.001, OR = 5.2 and p = 0.003, OR = 2.1, respectively). However, size > 20 mm was not significant in the subgroup of other-than-neuroendocrine tumor (NET) lesions. The EUS-TA accuracy was 92 %, and the rate of adverse events was 4 %. Conclusion Irregular margins on EUS are associated with malignancy/aggressiveness of nonhypovascular SPLs. Size > 20 mm should be considered a malignancy-related feature only in NET patients. EUS-TA is safe and highly accurate for differential diagnosis in this group of patients.

scholarly journals The Influence of Neoadjuvant Treatment on the Number of Lymph Nodes on the Surgical Specimen in Mid and Low Rectal Cancer - A Retrospective Single-Centre Study

Chirurgia ◽  
2019 ◽  
Vol 114 (2) ◽  
pp. 207
Author(s):  
Dragoş-Viorel Scripcariu ◽  
Gianina-Vanda Moraru ◽  
Ionuţ Huţanu ◽  
Bogdan Filip ◽  
Mihaela-Mădălina Gavrilescu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Nodes ◽  
Neoadjuvant Treatment ◽  
Low Rectal Cancer ◽  
Single Centre ◽  
Surgical Specimen ◽  
Centre Study ◽  
Single Centre Study

The Epidemiology of Metatarsal Fractures

2006 ◽  
Vol 27 (3) ◽  
pp. 172-174 ◽  
Author(s):  
Brad A. Petrisor ◽  
Ingri Ekrol ◽  
Charles Court-Brown
Keyword(s):  
Adult Population ◽  
Age Groups ◽  
Subsequent Treatment ◽  
Mechanism Of Injury ◽  
Associated Injuries ◽  
Demographic Information ◽  
Injury Patterns ◽  
Accurate Identification ◽  
Time Period ◽  
Metatarsal Fractures

Background: Metatarsal fractures are common injuries; however little has been written regarding their epidemiology in an adult population. Methods: All patients with metatarsal fractures during a 1-year time period were included in the study. Demographic information, grade, and mechanism of injury, associated injuries, and fracture location and type were recorded. Results: Three hundred and fifty-five patients with 411 metatarsal fractures were identified. The average age of the patients was 42 years. There was a higher proportion of women in the higher age groups, and the most common fracture was that of the fifth metatarsal. Multiple metatarsal fractures occurred in contiguous metatarsals, and 63% of third metatarsal fractures were associated with a fracture of either the second or fourth metatarsal. Conclusion: Knowledge of the epidemiology and injury patterns of metatarsal fractures can aid in the accurate identification and subsequent treatment of fractures of the metatarsals.

scholarly journals MON-250 Late Diagnosis of ACTH-secreting Pulmonary Neuroendocrine Tumor by Repeated 68Ga Dotatate Pet/ct: Influence of Tumor Size in Abnormal Uptake?

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Natália Xavier S Andrade ◽  
Ana Julia Garcia Pereira ◽  
Maria Candida Barisson Villares Fragoso ◽  
Marcello Delano Bronstein ◽  
Marcio Carlos Machado
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Neuroendocrine Tumor ◽  
Lung Nodule ◽  
Ectopic Acth ◽  
Pulmonary Carcinoid ◽  
Surgical Specimen ◽  
Pet Ct ◽  
Acth Secreting ◽  
Abnormal Uptake

Abstract Background: 68Ga DOTATATE PET/CT (68Ga-PET) has been proposed as a superior method in identifying ectopic ACTH syndrome (EAS). However, recent systematic review suggests its sensitivity is not as high as believed (1). We report a challenging case of EAS whose source was uncovered only after repeated 68Ga-PET. Clinical Case: A 15-year-old male presented with rapid onset of typical features of Cushing’s syndrome (CS) and metabolic impairment. Hormone evaluation confirmed severe ACTH-dependent CS. Pituitary transsphenoidal surgery was performed due to positive responses in desmopressin stimulation and high dose dexamethasone suppression test, in addition to a 4 mm nodule in pituitary MRI. No tumor was found in surgical specimen and no hormonal improvement was observed after surgery. Inferior petrosal sinus sampling demonstrated no central to peripheral ACTH gradient. Neck US, thorax/abdomen/pelvis CT were negative and PET-CT/FDG was inconclusive. OctreoScan® identified anomalous uptake on left mediastinum and led the patient to a thoracic surgery (TS) with nodule resection at left hilum. Pathology confirmed ACTH positive 10 mm neuroendocrine tumor (NET) infiltrating a lymph node. The patient had transient clinical and hormonal improvement, with recurrence 7 months later. Thoracic CT (T-CT) showed a 7 mm nodule on inferior segment of superior left lobe, PET-CT/FDG and OctreoScan® were negative but abnormal uptake was verified by 68Ga-PET in subcarinal area. A sub centimetric lymph node was resected and pathology confirmed ACTH positive NET, although the patient did not achieve remission. Octreotide LAR, cabergoline and ketoconazole did not control hypercortisolism and bilateral adrenalectomy was performed. Then, T-CT showed stable lung nodule and 2nd 68Ga-PET was negative. One year later, T-CT evidenced growth of lung nodule to 15 mm and 3rd 68Ga-PET demonstrated for the first time, abnormal uptake in this area. The patient underwent resection of left superior lung lobe along with ipsilateral hilar lymph nodes, and histopathology study revealed an ACTH-secreting atypical pulmonary carcinoid tumor with Ki67 of 10% and 5 out of 11 lymph nodes affected. ACTH fell from 288 to 64 pg/mL after surgery. Conclusion: Despite the high sensitivity attributed to 68Ga-PET, false negatives have been reported. In the present case, primary tumor was evidenced by 68Ga-PET seven years after the first resection of a metastatic lymph node, in the 3rd 68Ga-PET assessment and after tumor growth. This adds to the evidence that further studies are needed to better assess the accuracy of 68Ga-PET for EAS. Reference: [1] Varlamov et al. Diagnostic utility of Gallium-68-somatostatin receptor PET/CT in ectopic ACTH-secreting tumors: a systematic literature review and single-center clinical experience. Pituitary 2019; 22:445–455

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