Current Techniques Used for the Radiologic Assessment of Intracranial Neoplasms

2007 ◽  
Vol 131 (2) ◽  
pp. 252-260
Author(s):  
J. Matthew Debnam ◽  
Leena Ketonen ◽  
Leena M. Hamberg ◽  
George J. Hunter
Keyword(s):  
Mr Imaging ◽  
Imaging Techniques ◽  
Standard Of Care ◽  
Emission Tomography ◽  
Advanced Imaging ◽  
Intracranial Neoplasms ◽  
Radiologic Assessment ◽  
Positron Emission ◽  
Functional Mr Imaging ◽  
Perfusion Mr

Abstract Context.—Radiologic studies are obtained for diagnostic and treatment planning purposes in the evaluation of patients with intracranial neoplasms. These studies are discussed at radiology/pathology working conferences and are often beneficial in the analysis of pathologic specimens for tissue diagnosis. Therefore, clinical pathologists should be aware of the current and evolving imaging techniques that are used in the radiologic assessment of intracranial neoplasms. Objective.—To describe the imaging techniques used in the assessment of intracranial neoplasms and provide current references. Data Sources.—We searched PubMed for articles published between 1995 and 2006 and also reviewed several textbooks on intracranial neoplasms, to prepare a discussion of basic modalities such as computed tomography (CT) and magnetic resonance (MR) imaging as well as advanced imaging techniques such as CT and MR angiography and venography, CT and MR perfusion, MR spectroscopy, functional MR imaging, and positron emission tomography. Conclusions.—Knowledge of currently used imaging techniques for the assessment of intracranial neoplasms will assist the clinical pathologist in communications with neuroradiologists, surgeons, and referring clinicians. This review will also aid the pathologist in understanding the new and rapidly evolving imaging techniques that will likely become the standard of care in the future.

scholarly journals Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review

2010 ◽  
Vol 29 (3) ◽  
pp. E6 ◽  
Author(s):  
Peter G. Campbell ◽  
Pascal Jabbour ◽  
Sanjay Yadla ◽  
Issam A. Awad
Keyword(s):  
Mr Imaging ◽  
Diffusion Tensor ◽  
Imaging Techniques ◽  
Cerebral Cavernous Malformations ◽  
Advanced Imaging ◽  
Clinical Imaging ◽  
Cavernous Malformations ◽  
Concise Review ◽  
Intraoperative Management ◽  
Functional Mr Imaging

Cerebral cavernous malformations (CCMs) are divided into sporadic and familial forms. For clinical imaging, T2-weighted gradient-echo sequences have been shown to be more sensitive than conventional sequences. Recently more advanced imaging techniques such as high-field and susceptibility-weighted MR imaging have been employed for the evaluation of CCMs. Furthermore, diffusion tensor imaging and functional MR imaging have been applied to the preoperative and intraoperative management of these lesions. In this paper, the authors attempt to provide a concise review of the emerging imaging methods used in the clinical diagnosis and treatment of CCMs.

Integrated positron emission tomography and magnetic resonance imaging–guided resection of brain tumors: a report of 103 consecutive procedures

2006 ◽  
Vol 104 (2) ◽  
pp. 238-253 ◽  
Author(s):  
Benoît Pirotte ◽  
Serge Goldman ◽  
Olivier Dewitte ◽  
Nicolas Massager ◽  
David Wikler ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tumors ◽  
Mr Imaging ◽  
Tumor Resection ◽  
Tracer Uptake ◽  
Emission Tomography ◽  
Mr Images ◽  
Pet Tracer ◽  
Positron Emission ◽  
Pet Scanning

Object The aim of this study was to evaluate the integration of positron emission tomography (PET) scanning data into the image-guided resection of brain tumors. Methods Positron emission tomography scans obtained using fluorine-18 fluorodeoxyglucose (FDG) and l-[methyl-11C]methionine (MET) were combined with magnetic resonance (MR) images in the navigational planning of 103 resections of brain tumors (63 low-grade gliomas [LGGs] and 40 high-grade gliomas [HGGs]). These procedures were performed in 91 patients (57 males and 34 females) in whom tumor boundaries could not be accurately identified on MR images for navigation-based resection. The level and distribution of PET tracer uptake in the tumor were analyzed to define the lesion contours, which in turn yielded a PET volume. The PET scanning–demonstrated lesion volume was subsequently projected onto MR images and compared with MR imaging data (MR volume) to define a final target volume for navigation-based resection—the tumor contours were displayed in the microscope’s eyepiece. Maximal tumor resection was accomplished in each case, with the intention of removing the entire area of abnormal metabolic activity visualized during surgical planning. Early postoperative MR imaging and PET scanning studies were performed to assess the quality of tumor resection. Both pre- and postoperative analyses of MR and PET images revealed whether integrating PET data into the navigational planning contributed to improved tumor volume definition and tumor resection. Metabolic information on tumor heterogeneity or extent was useful in planning the surgery. In 83 (80%) of 103 procedures, PET studies contributed to defining a final target volume different from that obtained with MR imaging alone. Furthermore, FDG-PET scanning, which was performed in a majority of HGG cases, showed that PET volume was less extended than the MR volume in 16 of 21 cases and contributed to targeting the resection to the hypermetabolic (anaplastic) area in 11 (69%) of 16 cases. Performed in 59 LGG cases and 23 HGG cases, MET-PET demonstrated that the PET volume did not match the MR volume and improved the tumor volume definition in 52 (88%) of 59 and 18 (78%) of 23, respectively. Total resection of the area of increased PET tracer uptake was achieved in 54 (52%) of 103 procedures. Conclusions Imaging guidance with PET scanning provided independent and complementary information that helped to assess tumor extent and plan tumor resection better than with MR imaging guidance alone. The PET scanning guidance could help increase the amount of tumor removed and target image-guided resection to tumor portions that represent the highest evolving potential.

Basics of Imaging Techniques in Evaluation of Soft Tissue Tumors

2017 ◽  
Author(s):  
Emily Alanna Aherne ◽  
Sinchun Hwang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Imaging Techniques ◽  
Soft Tissue Tumors ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission

Medical imaging plays a pivotal role in the detection, diagnosis, and clinical management of primary soft tissue tumors. Various imaging modalities have been used, and each modality offers unique advantages in the workup of soft tissue tumors by localizing the lesions in different compartments of the body and characterizing macroscopic tissue composition of the lesions in a noninvasive and safe manner. We review the clinical role and technical aspects of the frequently used imaging modalities, including magnetic resonance imaging (MRI), computed tomography, ultrasonography, positron emission tomography, and plain radiography with an emphasis on MRI as a mainstay imaging modality and a brief discussion of advanced techniques. We also review imaging features of common soft tissue tumors that can be detected and characterized using current imaging techniques. This review contains 54 figures, 1 table and 37 references.   Key words: computed tomography, diffusion-weighted imaging, imaging, magnetic resonance imaging, positron emission tomography, soft tissue, technique, tumor, ultrasonography

Wavelet Transform-Based Soft Computational Techniques and Applications in Medical Imaging

2016 ◽  
pp. 339-363
Author(s):  
Shabana Urooj ◽  
Satya P. Singh
Keyword(s):  
Neural Networks ◽  
Wavelet Transform ◽  
Medical Imaging ◽  
Biomedical Applications ◽  
Imaging Techniques ◽  
Emission Tomography ◽  
Computational Techniques ◽  
Biomedical Image ◽  
Positron Emission ◽  
Neuro Imaging

The aim of this chapter is to highlight the biomedical applications of wavelet transform based soft computational techniques i.e. wavenet and corresponding research efforts in imaging techniques. A brief introduction of wavelet transform, its properties that are vital for biomedical applications touched by various researchers and basics of neural networks has been discussed. The concept of wavelon and wavenet is also discussed in detail. Recent survey of wavelet based neural networks in medical imaging is another facet of this script, which includes biomedical image denoising, image enhancement and functional neuro-imaging, including positron emission tomography and functional MRI.

scholarly journals Neurological update: neuroimaging in dementia

2020 ◽  
Vol 267 (11) ◽  
pp. 3429-3435
Author(s):  
Timothy Rittman
Keyword(s):  
Artificial Intelligence ◽  
Positron Emission Tomography ◽  
Clinical Practice ◽  
Imaging Techniques ◽  
Emission Tomography ◽  
Structural Imaging ◽  
Regulatory Issues ◽  
Positron Emission ◽  
Remarkable Progress

Abstract Neuroimaging for dementia has made remarkable progress in recent years, shedding light on diagnostic subtypes of dementia, predicting prognosis and monitoring pathology. This review covers some updates in the understanding of dementia using structural imaging, positron emission tomography (PET), structural and functional connectivity, and using big data and artificial intelligence. Progress with neuroimaging methods allows neuropathology to be examined in vivo, providing a suite of biomarkers for understanding neurodegeneration and for application in clinical trials. In addition, we highlight quantitative susceptibility imaging as an exciting new technique that may prove to be a sensitive biomarker for a range of neurodegenerative diseases. There are challenges in translating novel imaging techniques to clinical practice, particularly in developing standard methodologies and overcoming regulatory issues. It is likely that clinicians will need to lead the way if these obstacles are to be overcome. Continued efforts applying neuroimaging to understand mechanisms of neurodegeneration and translating them to clinical practice will complete a revolution in neuroimaging.

Radioligands for imaging myocardial α- and β-adrenoceptors

2003 ◽  
Vol 42 (01) ◽  
pp. 4-9 ◽  
Author(s):  
M. Schäfers ◽  
M. P. Law ◽  
T. Wichter ◽  
O. Schober ◽  
B. Riemann
Keyword(s):  
Single Photon ◽  
Heart Function ◽  
Specific Binding ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Relative Increase ◽  
Emission Tomography ◽  
Adrenoceptor Antagonist ◽  
Positron Emission ◽  
Cardiac Adrenoceptors

SummaryAlpha- and beta-adrenoceptors play an important role in the control of heart function. According to their molecular, biological, and pharmacological characteristics, they are subdivided into α1-, α2- and β1-, β2-, β3-, β4-adrenoceptors. In cardiac disease, there is often a selective downregulation of β1-adrenoceptors associated with a relative increase in β2- and α1-adrenoceptors. Functional imaging techniques like single-photon emission tomography (SPECT) and positron emission tomography (PET) provide the unique capability for non-invasive assessment of cardiac adrenoceptors. Radioligands with high specific binding to cardiac α- and β-adrenoceptors suitable for radiolabelling are required for clinical studies. The non-selective β-adrenoceptor antagonist [11C]CGP-12177 was used to quantify β-adrenoceptor density using PET in patients with heart disease. New non-selective ligands (e. g. [11C]CGP-12388, [18F]CGP-12388, [11C]carazolol and [18F]fluorocarazolol) are currently evaluated; β1-selective radioligands (e. g. [11C]CGP-26505, [11C]bisoprolol, [11C]HX-CH 44) and β2-selective radioligands (e. g. [11C]formoterol, [11C]ICI-118551) were assessed in animals. None of them turned out as suitable for cardiac PET.Potential radioligands for imaging cardiac α1-adrenoceptors are based on prazosin. Whereas [11C]prazosin shows low specific binding to myocardium, its derivative [11C]GB67 looks more promising. The putative α2-adrenoceptor radioligand [11C]MK-912 shows high uptake in rodent myocardium but has not yet been evaluated in man.A number of radioligands were evaluated for assessing cardiac adrenoceptors using PET. New radioligands are needed to provide more insight into cardiac pathophysiology which may influence the therapeutic management of patients with cardiovascular disease.

Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography

2003 ◽  
Vol 21 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Futoshi Mihara ◽  
Yasuo Kuwabara ◽  
Atsuo Tanaka ◽  
Takashi Yoshiura ◽  
Masayuki Sasaki ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Mr Imaging ◽  
Transit Time ◽  
Mean Transit Time ◽  
Emission Tomography ◽  
Positron Emission
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