Worldwide Overview of the Current Status of Lung Cancer Diagnosis and Treatment

2012 ◽  
Vol 136 (12) ◽  
pp. 1478-1481 ◽  
Author(s):  
Paul A. Bunn
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Kinase Inhibitors ◽  
False Positive Rate ◽  
Lung Cancer Mortality ◽  
Current Status ◽  
Advanced Lung Cancer ◽  
Lung Cancer Diagnosis ◽  
Positive Rate ◽  
Inhaled Prostacyclin

Lung cancer is the leading worldwide cause of cancer deaths. Smoking is the dominant cause of lung cancer and smoking cessation is the established method to reduce lung cancer mortality. While lung cancer risk is reduced in former smokers, they have a lifelong increase in risk, compared to never-smokers. Novel chemoprevention strategies, such as oral or inhaled prostacyclin analogs, hold promise for these subjects. Low-dose spiral computed tomography screening reduced lung cancer mortality by 20% in high-risk heavy smokers older than 50 years. However, the high false-positive rate (96%) means that screened patients required controlled follow-up in experienced centers. An increasing percentage of patients with advanced lung cancer have molecular drivers in genes for which oral tyrosine kinase inhibitors have been developed.

scholarly journals Targeted screening for lung cancer with autoantibodies.

2021 ◽  
Author(s):  
Frank Sullivan ◽  
Frances Mair ◽  
Will Anderson ◽  
Pauline Armory ◽  
Andrew Briggs ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Resource Constraints ◽  
Early Stage ◽  
False Positive Rate ◽  
Lung Cancer Mortality ◽  
Treatment Modalities ◽  
Early Stage Disease ◽  
Targeted Screening ◽  
Resource Requirements ◽  
Positive Rate

Earlier detection of lung cancer is possible, but difficult and costly to achieve. Screening with Low Dose Computed Tomography (LDCT)scanning has been shown to reduce mortality by 20-25% over the past decade but uptake amongst those most likely to suffer the disease has been slow. Resource constraints and a high false positive rate have also limited adoption of LDCT in many health systems. Targeted screening of people most likely to benefit using a range of biomarkers may be one way to improve the yield and reduce the resource requirements of LDCT. Autoantibodies, which amplify the signal produced by cancer derived proteins, are present in the blood of people mounting an immune response to cancer are a potential way to select those at highest risk. We have followed up 12 208 people enrolled in the ECLS trial for three years and shown that the specificity for early stage (I &II) disease is 90.3% throughout that period. More cancers were detected in the control than the intervention arm of the trial (101V 83). Sensitivity was 77.8% after 6 months and dropped to 46.4% after 3 years. At the end of three years the hazard ratios (95%CI) for All Cause, Cancer Specific and Lung Cancer Mortality was 0.82(0.67-1.01), 0.72(0.54-0.97) and 0.70(0.46-1.08) respectively for those randomised to Early CDT testing. As a range of treatment modalities become increasingly more effective it is even more important to target LDCT on those most likely to have early stage disease. Autoantibody testing may be one method of targeting early detection on those most likely to benefit.

Cancer as a Scottish Problem

1968 ◽  
Vol 13 (10) ◽  
pp. 338-348
Author(s):  
A. J. Haddow
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cause Of Death ◽  
Cancer Mortality ◽  
Time Lag ◽  
Age Distribution ◽  
Lung Cancer Mortality ◽  
Cervix Uteri ◽  
Hospital Treatment ◽  
Cancer Of The Lung

Cancer, responsible for about 1 death in 5 in Scotland, cost over £1 per head of population in 1965 and led to bed occupation of almost 2,000 bed years. Time lag (symptoms-doctor-hospital-treatment) is usuallv small. Age distribution is as in other European countries. Excluding accidents, cancer is the second most important cause of death in children. In relation to other countries Scotland's position is very poor and the lung cancer mortality in both sexes is the highest known. Lung cancer is the most important in males, breast cancer in females. Alimentary cancers come second in both sexes. In this century alimentary cancers increased till the thirties or forties and then declined. Cancers of pancreas, cervix uteri, ovary, prostate, kidney and bladder, together with leukaemia, have all increased. Cancer of the lung has increased elevenfold in women and fiftyfold in men. It now accounts for 9 to 12 per cent of all male deaths in cities and large towns

scholarly journals Lung cancer mortality attributable to residential radon exposure in Spain and its regions

2021 ◽  
pp. 111372
Author(s):  
Alberto Ruano-Ravina ◽  
Leonor Varela Lema ◽  
Marta García Talavera ◽  
Montserrat García Gómez ◽  
Santiago González Muñoz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Radon Exposure ◽  
Its Regions ◽  
Residential Radon

The effect of psychosocial factors on lung cancer mortality at one year

1988 ◽  
Vol 41 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Kathleen M. Stavraky ◽  
Allan P. Donner ◽  
Jean E. Kincade ◽  
Moira A. Stewart
Keyword(s):  
Lung Cancer ◽  
Psychosocial Factors ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
One Year
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