scholarly journals Glandular Tumors of the Urachus and Urinary Bladder: A Practical Overview of a Broad Differential Diagnosis

2018 ◽  
Vol 142 (10) ◽  
pp. 1164-1176 ◽  
Author(s):  
Alexander S. Taylor ◽  
Rohit Mehra ◽  
Aaron M. Udager
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Urinary Bladder ◽  
Molecular Pathology ◽  
Routine Clinical Practice ◽  
Diagnostic Features ◽  
Molecular Features ◽  
Urothelial Carcinomas ◽  
Cystic Tumors ◽  
Diagnostic Framework

Primary glandular tumors of the urachus and urinary bladder are an intriguing group of clinically and morphologically diverse neoplasms for which there have been recent refinements in diagnostic subclassification and advances in molecular pathology. In addition, the urachus and urinary bladder may be secondarily involved by tumors with glandular differentiation that demonstrate remarkable morphologic, immunophenotypic, and molecular overlap. Thus, surgical pathologists need to be aware of the broad differential diagnosis of glandular tumors that involve the urachus and urinary bladder and have a practical diagnostic framework to evaluate these lesions in routine clinical practice. In this review, we summarize the salient clinical, morphologic, immunohistochemical, and molecular features of glandular tumors of the urachus and urinary bladder, including mucinous cystic tumors of the urachus, noncystic urachal adenocarcinomas, urothelial carcinomas with glandular or pseudoglandular features, primary urinary bladder adenocarcinomas, and Müllerian-type carcinomas, highlighting the strengths and limitations of various diagnostic features and ancillary tests, as well as the need for close clinical and radiographic correlation.

scholarly journals Clinical Features, Histopathology and Differential Diagnosis of Sarcoidosis

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 59
Author(s):  
Claudio Tana ◽  
Iginio Donatiello ◽  
Alessandro Caputo ◽  
Marco Tana ◽  
Teresa Naccarelli ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Lymph Nodes ◽  
Clinical Features ◽  
Routine Clinical Practice ◽  
The Other ◽  
Unknown Etiology ◽  
Histopathological Findings ◽  
Clinical Pictures ◽  
Granulomatous Disorders

Sarcoidosis is a chameleon disease of unknown etiology, characterized by the growth of non-necrotizing and non-caseating granulomas and manifesting with clinical pictures that vary on the basis of the organs that are mainly affected. Lungs and intrathoracic lymph nodes are the sites that are most often involved, but virtually no organ is spared from this disease. Histopathology is distinctive but not pathognomonic, since the findings can be found also in other granulomatous disorders. The knowledge of these findings is important because it could be helpful to differentiate sarcoidosis from the other granulomatous-related diseases. This review aims at illustrating the main clinical and histopathological findings that could help clinicians in their routine clinical practice.

Inflammatory Pseudotumor of the Spleen in a 6-Year-Old Child: A Clinicopathologic Study

2003 ◽  
Vol 127 (3) ◽  
pp. e127-e130 ◽  
Author(s):  
Ashit Sarker ◽  
Caroline An ◽  
Mary Davis ◽  
Darja Praprotnik ◽  
Leo J. McCarthy ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Vesicoureteral Reflux ◽  
Reflux Disease ◽  
Inflammatory Pseudotumor ◽  
Mass Lesion ◽  
Diagnostic Features ◽  
Molecular Features ◽  
Clinicopathologic Study ◽  
Inflammatory Pseudotumors

Abstract Inflammatory pseudotumors of the spleen are extremely rare in children. To our knowledge, only 3 cases of splenic inflammatory pseudotumors have been reported. An inflammatory pseudotumor of the spleen was found incidentally during the workup of vesicoureteral reflux disease in a 6-year-old girl. The clinical, pathologic, immunophenotypic, and molecular features and the differential diagnostic features are discussed here. Splenic inflammatory pseudotumors, although rare, should be considered in the differential diagnosis of a mass lesion of the spleen in children.

scholarly journals Inflammatory Myofibroblastic Tumor of the Bladder

2014 ◽  
Vol 138 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
Megan Alderman ◽  
Lakshmi P. Kunju
Keyword(s):  
Differential Diagnosis ◽  
Urinary Bladder ◽  
Inflammatory Myofibroblastic Tumor ◽  
Sarcomatoid Carcinoma ◽  
Muscularis Propria ◽  
Inflammatory Cells ◽  
Diagnostic Features ◽  
Anaplastic Lymphoma ◽  
Diagnostic Pitfall ◽  
Eosinophilic Cytoplasm

We illustrate a case of an inflammatory myofibroblastic tumor (IMT) involving the bladder in a woman with dysuria and review the literature and differential diagnosis. Inflammatory myofibroblastic tumor, also referred to as pseudosarcomatous myofibroblastic proliferation, is a rare lesion that can arise in the genitourinary system and is characterized by a fascicular arrangement of myofibroblasts with admixed inflammatory cells and slitlike vessels. Urinary bladder IMT can be a diagnostic pitfall because its histologic features (brisk mitoses, invasion into muscularis propria, and prominent nucleoli) can mimic malignancy. The differential diagnosis of urinary bladder IMT includes sarcomatoid carcinoma and leiomyosarcoma. Diagnostic features such as bland nuclear chromatin, ganglion-like cells, pale eosinophilic cytoplasm with long processes, overexpression of anaplastic lymphoma kinase (immunohistochemistry or gene rearrangement studies), and the absence of atypical mitoses help distinguish IMT from its malignant mimics. Current controversies regarding postoperative spindle cell nodule and IMT are discussed.

scholarly journals "Tails-up" capnogram: The role in detecting anaesthetic equipment malfunction

2017 ◽  
Vol 74 (9) ◽  
pp. 900-903
Author(s):  
Stevan Mihailovic
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Practice ◽  
Perioperative Period ◽  
Routine Clinical Practice ◽  
Surgical Operation ◽  
Monitoring Tool ◽  
Anaesthetic Equipment ◽  
Course Of Action ◽  
Depth Analysis

Introduction. Capnography is an essential part and standard monitoring tool during the perioperative period, which can be invaluable in detecting anaesthetic equipment malfunction. Case report. The atypical, ??tails-up?? capnographic waveform was noticed during routine surgical operation. Comprehensive physico-mathematical and graphical explanation of this complex capnographic pattern has been given, together with in-depth analysis of possible differential diagnosis and clinical significance for routine clinical practice. Conclusion. ?Tails-up?? capnographic trace gives early clue to diagnosing and fixing the problem of cracks in sampling line, before leading to an inadequate course of action. The understanding of the physics and physiology behind capnography is of vital importance for the analysis of capnographic waveforms, for early detection of anaesthetic equipment malfunction and for safe clinical practice.

scholarly journals Еlectrocardiographic criteria and algorithms for differential diagnosis of wide QRS complexes arrhythmias

2021 ◽  
Vol 27 (4) ◽  
pp. 24-32
Author(s):  
M. A. Budanova ◽  
M. P. Chmelevsky ◽  
T. V. Treshkur ◽  
V. M. Tikhonenko
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
High Precision ◽  
Diagnostic Errors ◽  
Routine Clinical Practice ◽  
Special Equipment ◽  
Electrophysiological Examination ◽  
Ecg Criteria

Differential diagnosis of ventricular and supraventricular wide QRS complexes arrhythmias remains one of the most urgent and serious problems of modern cardiology. High-precision intracardiac and transesophageal electrophysiological examination cannot be widely used in routine clinical practice because of the complexity of using, the risk of complications, and the necessary of special equipment. The availability and simplicity of electrocardiogram registration was the reason for study and development of ECG criteria and algorithms for differential diagnosis. However, their low accuracy, variety, complexity and laboriousness of application often leads to diagnostic errors and low usage of clinicians.

POST-TRANSFUSION PURPURA VS. HEPARIN-INDUCED THROMBOCYTOPENIA: DIFFERENTIAL DIAGNOSIS IN CLINICAL PRACTICE

2000 ◽  
Vol 10 (4) ◽  
pp. 323-324 ◽  
Author(s):  
F. Araujo ◽  
J. J. Sa ◽  
V. Araujo ◽  
M. Lopes ◽  
L. M. Cunha-Ribeiro
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Heparin Induced Thrombocytopenia

Diagnosis and Management of Cardiomyopathies – A Focus on Genetics, Cardiac Magnetic Resonance and Clinical Features

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Routine Clinical Practice ◽  
Clinical Approach ◽  
Diagnosis And Management ◽  
Made In

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.

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