scholarly journals Overactivation of the Aldosterone^|^frasl;Mineralocorticoid Receptor System in Metabolic Syndrome and its Implication in Cardiac and Kidney Injury

2012 ◽  
Vol 12 (1) ◽  
pp. 11-21
Author(s):  
Miki Nagase
Keyword(s):  
Metabolic Syndrome ◽  
Mineralocorticoid Receptor ◽  
Kidney Injury ◽  
Receptor System

scholarly journals SP074SERINE PROTEASE INHIBITION ATTENUATES SALT-SENSITIVE HYPERTENSION AND KIDNEY INJURY IN A RAT MODEL OF METABOLIC SYNDROME

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i110-i110
Author(s):  
Yutaka Kakizoe ◽  
Teruhiko Mizumoto ◽  
Terumasa Nakagawa ◽  
Manabu Hayata ◽  
Yuichiro Izumi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model ◽  
Kidney Injury ◽  
Protease Inhibition ◽  
Salt Sensitive Hypertension

scholarly journals Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome: A Role for Aldosterone and the Mineralocorticoid Receptor

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Eric E. Essick ◽  
Flora Sam
Keyword(s):  
Metabolic Syndrome ◽  
Cardiac Hypertrophy ◽  
Cross Talk ◽  
Mineralocorticoid Receptor ◽  
Ventricular Hypertrophy ◽  
Cardiac Fibrosis ◽  
Cardiovascular Complications ◽  
Left Ventricular ◽  
The Metabolic Syndrome ◽  
Increased Risk

Obesity and hypertension, major risk factors for the metabolic syndrome, render individuals susceptible to an increased risk of cardiovascular complications, such as adverse cardiac remodeling and heart failure. There has been much investigation into the role that an increase in the renin-angiotensin-aldosterone system (RAAS) plays in the pathogenesis of metabolic syndrome and in particular, how aldosterone mediates left ventricular hypertrophy and increased cardiac fibrosis via its interaction with the mineralocorticoid receptor (MR). Here, we review the pertinent findings that link obesity with elevated aldosterone and the development of cardiac hypertrophy and fibrosis associated with the metabolic syndrome. These studies illustrate a complex cross-talk between adipose tissue, the heart, and the adrenal cortex. Furthermore, we discuss findings from our laboratory that suggest that cardiac hypertrophy and fibrosis in the metabolic syndrome may involve cross-talk between aldosterone and adipokines (such as adiponectin).

Laser Therapy in Metabolic Syndrome-Related Kidney Injury

2013 ◽  
Vol 89 (4) ◽  
pp. 953-960 ◽  
Author(s):  
Alvaro C. Ucero ◽  
Bettina Sabban ◽  
Alberto Benito-Martin ◽  
Susana Carrasco ◽  
Stephan Joeken ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Laser Therapy ◽  
Kidney Injury

Mineralocorticoid receptor in adipocytes and macrophages: A promising target to fight metabolic syndrome

Steroids ◽  
2014 ◽  
Vol 91 ◽  
pp. 46-53 ◽  
Author(s):  
Vincenzo Marzolla ◽  
Andrea Armani ◽  
Alessandra Feraco ◽  
Massimo U. De Martino ◽  
Andrea Fabbri ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mineralocorticoid Receptor ◽  
Promising Target
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