scholarly journals SP074SERINE PROTEASE INHIBITION ATTENUATES SALT-SENSITIVE HYPERTENSION AND KIDNEY INJURY IN A RAT MODEL OF METABOLIC SYNDROME

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i110-i110
Author(s):  
Yutaka Kakizoe ◽  
Teruhiko Mizumoto ◽  
Terumasa Nakagawa ◽  
Manabu Hayata ◽  
Yuichiro Izumi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model ◽  
Kidney Injury ◽  
Protease Inhibition ◽  
Salt Sensitive Hypertension

scholarly journals SP072THE EFFECTS OF SERINE PROTEASE INHIBITION ON SALT-SENSITIVE HYPERTENSION AND PODOCYTE INJURY IN A RAT MODEL OF METABOLIC SYNDROME

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i369-i370
Author(s):  
Yutaka Kakizoe ◽  
Teruhiko Mizumoto ◽  
Terumasa Nakagawa ◽  
Yoshikazu Miyasato ◽  
Yasunobu Iwata ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serine Protease ◽  
Rat Model ◽  
Protease Inhibition ◽  
Podocyte Injury ◽  
Salt Sensitive Hypertension

MPS 01-03 SERINE PROTEASE INHIBITION ATTENUATES SALT-SENSITIVE HYPERTENSION AND PODOCYTE INJURY IN A RAT MODEL OF METABOLIC SYNDROME

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e78
Author(s):  
Yutaka Kakizoe ◽  
Teruhiko Mizumoto ◽  
Terumasa Nakagawa ◽  
Manabu Hayata ◽  
Yoshikazu Miyasato ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serine Protease ◽  
Rat Model ◽  
Protease Inhibition ◽  
Podocyte Injury ◽  
Salt Sensitive Hypertension

Myocardial Ischemic-reperfusion Injury in a Rat Model of Metabolic Syndrome

Obesity ◽  
2008 ◽  
Vol 16 (10) ◽  
pp. 2253-2258 ◽  
Author(s):  
Mahmood S. Mozaffari ◽  
Stephen W. Schaffer
Keyword(s):  
Metabolic Syndrome ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion

scholarly journals Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model

2021 ◽  
Vol 22 (7) ◽  
pp. 3762
Author(s):  
Sarah M. Kedziora ◽  
Kristin Kräker ◽  
Lajos Markó ◽  
Julia Binder ◽  
Meryam Sugulle ◽  
...  
Keyword(s):  
Rat Model ◽  
Renal Damage ◽  
Kidney Injury ◽  
Tissue Growth ◽  
Female Rats ◽  
Male Rats ◽  
Renal Diseases ◽  
Transgenic Rat ◽  
Increased Risk ◽  
Before And After

Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life. However, in human studies PE as a single cause of this development cannot be investigated. Here, we aimed to investigate the effect of PE on postpartum renal damage in an established transgenic PE rat model. Female rats harboring the human-angiotensinogen gene develop a preeclamptic phenotype after mating with male rats harboring the human-renin gene, but are normotensive before and after pregnancy. During pregnancy PE rats developed mild tubular and glomerular changes assessed by histologic analysis, increased gene expression of renal damage markers such as kidney injury marker 1 and connective-tissue growth factor, and albuminuria compared to female wild-type rats (WT). However, four weeks postpartum, most PE-related renal pathologies were absent, including albuminuria and elevated biomarker expression. Only mild enlargement of the glomerular tuft could be detected. Overall, the glomerular and tubular function were affected during pregnancy in the transgenic PE rat. However, almost all these pathologies observed during PE recovered postpartum.

scholarly journals The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome

2014 ◽  
Vol 37 (7) ◽  
pp. 629-635 ◽  
Author(s):  
Hironori Nakagami ◽  
Zhengda Pang ◽  
Takashi Shimosato ◽  
Toshinori Moritani ◽  
Hitomi Kurinami ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Rat Model ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitor

scholarly journals Insulin resistance in penile arteries from a rat model of metabolic syndrome

2010 ◽  
Vol 161 (2) ◽  
pp. 350-364 ◽  
Author(s):  
Cristina Contreras ◽  
Ana Sánchez ◽  
Pilar Martínez ◽  
Rafaela Raposo ◽  
Belén Climent ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Rat Model ◽  
Penile Arteries

Metabolomic profiling of urine-derived extracellular vesicles from rat model of drug-induced acute kidney injury

2021 ◽  
Vol 546 ◽  
pp. 103-110
Author(s):  
Masayoshi Saito ◽  
Satoshi Horie ◽  
Hidenori Yasuhara ◽  
Akane Kashimura ◽  
Eiji Sugiyama ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Extracellular Vesicles ◽  
Rat Model ◽  
Kidney Injury ◽  
Drug Induced ◽  
Metabolomic Profiling

Vitamin D3 potentiates the nephroprotective effects of vildagliptin‐metformin combination in a rat model of metabolic syndrome

2021 ◽  
Author(s):  
Nehal S. Wahba ◽  
Rasha H. Abdel‐Ghany ◽  
Salah A. Ghareib ◽  
Mohamed Abdel‐Aal ◽  
Amira E. Alsemeh ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D3 ◽  
Rat Model
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