scholarly journals Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?

2013 ◽  
Vol 15 (3) ◽  
pp. 175-181 ◽  
Author(s):  
Zohreh Soltani ◽  
Kashaf Rasheed ◽  
Daniel R. Kapusta ◽  
Efrain Reisin
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Diseases ◽  
Potential Role ◽  
Kidney Injury

The Potential Role of Antioxidants in Metabolic Syndrome

2016 ◽  
Vol 22 (7) ◽  
pp. 859-869 ◽  
Author(s):  
Bianca Martins Gregório ◽  
Diogo Benchimol De Souza ◽  
Fernanda Amorim de Morais Nascimento ◽  
Leonardo Matta ◽  
Caroline Fernandes-Santos
Keyword(s):  
Metabolic Syndrome ◽  
Potential Role

scholarly journals The Role of Uridine Adenosine Tetraphosphate in the Vascular System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Rita C. Tostes ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Smooth Muscle Cells ◽  
Vascular Function ◽  
Purinergic Receptors ◽  
Potential Role ◽  
Vascular System

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

scholarly journals The potential role of miRNAs in calcification of cardiovascular diseases

2019 ◽  
pp. 118-125 ◽  
Author(s):  
A. G. Ibragimova ◽  
K. R. Shakhmaeva ◽  
I. E. Stanishevskaya ◽  
A. V. Shindyapina
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role

scholarly journals MicroRNA-143/-145 in Cardiovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Zhao ◽  
Shui-Ping Zhao ◽  
Yu-Hong Zhao
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle Cells ◽  
Essential Role ◽  
Recent Progress ◽  
Potential Role ◽  
Phenotypic Switching ◽  
Diagnostic Biomarkers ◽  
Potential Strategy

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components

2019 ◽  
Vol 44 (4) ◽  
pp. 865-874 ◽  
Author(s):  
Mahantesh I. Biradar ◽  
Kuang-Mao Chiang ◽  
Hsin-Chou Yang ◽  
Yen-Tsung Huang ◽  
Wen-Harn Pan
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Waist Circumference ◽  
Causal Role ◽  
Metabolic Syndrome Components

scholarly journals Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients

2019 ◽  
Vol Volume 12 ◽  
pp. 601-611 ◽  
Author(s):  
Mohamed Bakr Zaki ◽  
Ahmed Ibrahim Abulsoud ◽  
Ahmed Mohamed Elsisi ◽  
Ahmed Soliman Doghish ◽  
Ossama Abd Elmotaal Mansour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Potential Role ◽  
Circulating Micrornas ◽  
Male Patients

Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization?

2012 ◽  
Vol 38 (3) ◽  
pp. 467-473 ◽  
Author(s):  
Perrine Hoet ◽  
Vincent Haufroid ◽  
Gladys Deumer ◽  
Xavier Dumont ◽  
Dominique Lison ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Potential Role ◽  
Kidney Injury

scholarly journals Evaluation of Lipid Peroxidation and Antioxidants’ Status in Metabolic Syndrome

2012 ◽  
Vol 8 (4) ◽  
pp. 382-386 ◽  
Author(s):  
S Shrestha ◽  
L Chandra ◽  
M Aryal ◽  
B K L Das ◽  
S Pandey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Diseases ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Health Sciences ◽  
Sectional Study ◽  
Cross Sectional ◽  
Staff Members

Background Metabolic syndrome is a constellation of physical conditions and metabolic abnormalities, commonly occurring together, that increases an individual’s risk for development of type 2 diabetes mellitus and cardiovascular diseases. Oxidative stress is associated with diabetes, hypertension and other cardiovascular diseases while the role of oxidative stress in pathogenesis of MS is not clearlydefined. Objectives The study aims to find out the prevalence of metabolic syndrome in faculty and staff members at BP Koirala Institute of Health Sciences, Dharan, Nepal and to evaluate oxidative stress levels insubjects with metabolic syndrome. Methods 118 healthy participants working at B. P. Koirala Institute of Health Sciences, Dharan, Nepal were selected at random for this cross-sectional study and blood samples were collected for the estimation of the following biochemical analytes; fasting glucose; triglycerides; total cholesterol; high density lipoprotein cholesterol; Albumin; uric acid; Bilirubin; Malondialdehyde; Catalase; Glutathione peroxidase; Superoxide Dismutase; Glutathione; vitamin C; and lastly vitamin E. Results In this cross-sectional study, 39% subjects were diagnosed with metabolic syndrome , particularly in sedentary subjects. There was no difference in oxidative stress except significant rises in serum uric acid levels and catalase activity in subjects diagnosed with metabolic syndrome . Conclusion The prevalence of metabolic syndrome is higher without oxidative stress in this study, which suggests that oxidative stress does not contribute to the pathogenesis of MS in otherwise healthy subjects.http://dx.doi.org/10.3126/kumj.v8i4.6236 Kathmandu Univ Med J 2010;8(4):382-6   

scholarly journals Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling

2016 ◽  
Vol 9 (3) ◽  
pp. 444-453 ◽  
Author(s):  
Vibha Bhatnagar ◽  
Erin L. Richard ◽  
Wei Wu ◽  
Caroline M. Nievergelt ◽  
Michael S. Lipkowitz ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Potential Role
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