Role of 2nd Digit: 4th Digit Ratio(2D: 4D Ratio) in Establishing the Biological Profile of an Individual

2019 ◽  
Vol 19 (2) ◽  
pp. 175
Author(s):  
Santosh Sheelavant ◽  
Manjula Patil
Author(s):  
I. N. Yezhov ◽  
Yu. I. Yashechkin ◽  
M. N. Lyapin ◽  
I. G. Drozdov

Within the frames of an analytical review, modern approaches are described whose development is considered to be very important in order to rationally operate secure working procedures at the facilities of medical and biological profile. Peculiarities of formulating the methods to assess biological hazards are analyzed together with the ways of their objectivization. The place and the role of biological safety as a scientific trend are discussed in relation with the problem of availability of practical application of the "risk theory" elements with the aim of making governing decisions based on complex, well established estimations. The architecture of the system of modeling and estimation of potential danger associated with handling pathogenic biological agents is enunciated.


2018 ◽  
Vol 72 ◽  
pp. 86-94 ◽  
Author(s):  
Andreas Friedl ◽  
Levent Neyse ◽  
Ulrich Schmidt
Keyword(s):  

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2059 ◽  
Author(s):  
Gino Marioni ◽  
Leonardo Franz ◽  
Giancarlo Ottaviano ◽  
Giacomo Contro ◽  
Giulia Tealdo ◽  
...  

Small pretreatment laryngeal biopsies may not fully represent a tumor’s biological profile. This study on laryngeal squamous cell carcinoma (LSCC) aimed to investigate the prognostic role of CD105- and CD31-assessed microvessel density (MVD) in paired biopsies and surgical specimens and the association and discrepancy between CD105- and CD31-assessed MVD in biopsies and surgical specimens. CD105- and CD31-assessed MVD was analyzed in paired biopsies and surgical specimens of 45 consecutive cases of LSCC. In the LSCC biopsies and surgical specimens, median CD105-assessed MVD was significantly higher in N+ than in N0 cases (p = 0.0008, and p = 0.0002, respectively). Disease-free survival (DFS) was associated with CD105- and CD31-assessed MVD in both biopsies and surgical specimens (p < 0.0001 for all specimens). Multivariable Cox’s regression showed that pathological grade (p < 0.0001) and CD105-assessed MVD in LSCC biopsies (p = 0.0209) predicted DFS. Lin’s concordance coefficient showed that CD31 overestimated MVD compared with CD105 in LSCC biopsies and surgical specimens. CD105-assessed MVD should be further investigated in larger LSCC series as a potential prognostic marker for identifying: patients at higher risk of recurrence who might warrant more aggressive therapy; and cN0 patients requiring elective neck dissection for a significant risk of regional metastasis.


2021 ◽  
Vol 10 (10) ◽  
pp. 2045
Author(s):  
Antonin Trimaille ◽  
Anaïs Curtiaud ◽  
Kensuke Matsushita ◽  
Benjamin Marchandot ◽  
Jean-Jacques Von Hunolstein ◽  
...  

Introduction. Acute pulmonary embolism (APE) is a frequent condition in patients with COVID-19 and is associated with worse outcomes. Previous studies suggested an immunothrombosis instead of a thrombus embolism, but the precise mechanisms remain unknown. Objective. To assess the determinants and prognosis of APE during COVID-19. Methods. We retrospectively included all consecutive patients with APE confirmed by computed tomography pulmonary angiography hospitalized at Strasbourg University Hospital from 1 March to 31 May 2019 and 1 March to 31 May 2020. A comprehensive set of clinical, biological, and imaging data during hospitalization was collected. The primary outcome was transfer to the intensive care unit (ICU). Results. APE was diagnosed in 140 patients: 59 (42.1%) with COVID-19, and 81 (57.9%) without COVID-19. A 812% reduction of non-COVID-19 related APE was registered during the 2020 period. COVID-19 patients showed a higher simplified pulmonary embolism severity index (sPESI) score (1.15 ± 0.76 vs. 0.83 ± 0.83, p = 0.019) and were more frequently transferred to the ICU (45.8% vs. 6.2%, p < 0.001). No difference regarding the most proximal thrombus localization, Qanadli score (8.1 ± 6.9 vs. 9.0 ± 7.4, p = 0.45), the proportion of subsegmental (10.2% vs. 11.1%, p = 0.86), and segmental pulmonary embolism (35.6% vs. 24.7%, p = 0.16) was evidenced between COVID-19 and non-COVID-19 APE. In COVID-19 patients with subsegmental or segmental APE, thrombus was, in all cases (27/27 patients), localized in areas with COVID-19-related lung injuries. Marked inflammatory and prothrombotic biological markers were associated with COVID-19 APE. Conclusions. APE patients with COVID-19 have a particular clinico–radiological and biological profile and a dismal prognosis. Our results emphasize the preeminent role of inflammation and a prothrombotic state in these patients.


2019 ◽  
pp. e23260
Author(s):  
Miroslav Králík ◽  
Adela Hupková ◽  
Tomáš Zeman ◽  
Martin Hložek ◽  
Lukáš Hlaváček ◽  
...  

2021 ◽  
Vol 1 (3) ◽  
pp. 138-147
Author(s):  
Alessia Leggio ◽  
Pietro Tarzia ◽  
Francesco Introna

Forensic anthropological investigations often encounter cases that are difficult to interpret, especially when dealing with skeletal remains found in a marine context. Determining the immersion time in the sea of skeletal remains is a challenge for forensic investigations and answering this would solve many cases in the shortest time possible. The physical and chemical properties of bones change during their time in water and these changes cause difficulties and delays in identifying and reconstructing the biological profile of an unknown subject. In this paper, two forensic cases found at sea were analysed, the case of a disarticulated and extensively skeletonised corpse found on the coast of Reggio Calabria (Italy) and the case of an isolated foot, intact of soft tissues, found only 9 km away, on the coast of Vibo Valentia (Italy). The resolution hypothesis of the two cases was based on three search options because the disappearance of three known individuals was being investigated simultaneously. The investigations were conducted through a multidisciplinary work applying different analyses, including anthropometric, radiological, digital and, finally, genetic analyses. The results made it possible to determine the reconstruction of two biological profiles, both of Case A, the skeletal remain, and Case B, the subject to whom the foot belonged. The almost compatible anthropometric results of the two biological profiles, the presence of two very indicative partial tattoos and a genetic correlation led to the solution of a single court case.


2020 ◽  
Vol 56 (1&2) ◽  
pp. 42-72
Author(s):  
Jahm Mae Guinto ◽  
Charlotte May Amante ◽  
Franz Nicole Carlos ◽  
Arlene Daro ◽  
Mariella Jasmin Marasigan ◽  
...  

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 283-286
Author(s):  
G. B. Vidya ◽  
S Bhat ◽  
L.B. Kavitha

Introduction and Aim: Prenatal androgens are believed to be one of the probable etiological factors influencing intellectual development of an individual. In-utero testosterone exposure has been thought to affect the digit ratio which is the ratio of lengths of index finger and ring finger (2D:4D). In the present work we intended to study the correlation of 2D:4D with numerical and verbal intelligence believed to be variable among genders. The aim of our study was to find the association of 2D:4D with Verbal Intelligence and Numerical Intelligence in a sample of medical students.                                Materials and Methods: This study was conducted in a sample of medical students. 44 female and 44 male students participated in the study. 2D:4D measurements were made using standard procedure after which the participants completed a questionnaire containing 20 questions each to test numerical and verbal intelligence.   Results: In this study, Males were found to have a lower 2D:4D when compared to females. Individuals with lower 2D:4D in their right-hand were seen to have lower verbal intelligence and higher numerical intelligence thus suggesting that males are born with  better numerical intelligence and females with greater verbal intelligence.   Conclusion: Digit ratio can be considered as a valuable indicator of individual differences in terms of intelligence, although the exact role of testosterone on brain to cause variation in these cognitive domains is yet to be clearly understood.


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