Phytochemical analysis of Curculigo orchioides and its cytotoxic effect on lung adenocarcinoma cancer cell line (NCI-H522)

2020 ◽  
Vol 12 (3) ◽  
pp. 400
Author(s):  
Khyahrii S Aloysius ◽  
K Sharanya ◽  
Sudarshan Kini ◽  
Gaurav R Milan ◽  
Smitha Hegde
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Phytochemical Analysis ◽  
Curculigo Orchioides ◽  
Lung Adenocarcinoma Cancer

Synthesis and Anticancer Activity of New Hydrazide-hydrazones and Their Pd(II) Complexes

2019 ◽  
Vol 16 (5) ◽  
pp. 522-532 ◽  
Author(s):  
Bedia Kocyigit-Kaymakcioglu ◽  
Senem Sinem Yazici ◽  
Fatih Tok ◽  
Miriş Dikmen ◽  
Selin Engür ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
A549 Cells ◽  
Cancer Cell Line ◽  
Fibroblast Cell ◽  
Reference Drug ◽  
A549 Cancer Cell Line

Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: 5-Chloro-N’-[(substituted)methylidene] pyrazine-2-carbohydrazide (3a-g) and their Pd(II) complexes (4a-h) were synthesized and investigated in vitro anticancer activity on A549, Caco2 cancer and normal 3T3 fibroblast cell lines, using the MTT assay. Results: Anticancer activity screening results revealed that some compounds showed remarkable cytotoxic effect. Among them, 5-chloro-N'-[(4-hydroxyphenyl)methylidene] pyrazine-2-carbohydrazide (3c) displayed higher cytotoxic activity against A549 cancer cell line than the reference drug cisplatin. Conclusion: Compound 3c showed high cytotoxic activity against A549 cancer cell line but it showed low cytotoxic effect against normal 3T3 fibroblast cell line. Antiproliferative and antimetastatic effects of 3c were determined by the real-time monitoring of cell proliferative system (RTCA DP). The cell proliferation, metastatic and invasive activities of A549 cells were decreased due to increased concentration of 3c.

scholarly journals Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3712
Author(s):  
Paola Peinado ◽  
Alvaro Andrades ◽  
Marta Cuadros ◽  
Maria Isabel Rodriguez ◽  
Isabel F. Coira ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Genetic Alterations ◽  
Cell Models ◽  
Functional Studies ◽  
Cellular Models ◽  
Mutational Status

Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead to the discovery of new therapeutic drugs. However, choosing an appropriate cancer cell line model for SWI/SNF functional studies can be challenging because SWI/SNF subunits are frequently altered in cancer by various mechanisms, including genetic alterations and post-transcriptional mechanisms. In this work, we combined genomic, transcriptomic, and proteomic approaches to study the mutational status and the expression levels of the SWI/SNF subunits in a panel of 38 lung adenocarcinoma (LUAD) cell lines. We found that the SWI/SNF complex was mutated in more than 76% of our LUAD cell lines and there was a high variability in the expression of the different SWI/SNF subunits. These results underline the importance of the SWI/SNF complex as a tumor suppressor in LUAD and the difficulties in defining altered and unaltered cell models for the SWI/SNF complex. These findings will assist researchers in choosing the most suitable cellular models for their studies of SWI/SNF to bring all of its potential to the development of novel therapeutic applications.

scholarly journals Study of the Cytotoxic Effect of New Copper(II) Complexes and Aqueous Extract of Origanum Vulgare L. Plant on Cancer )Cell Line RD)

2012 ◽  
Vol 15 (2) ◽  
pp. 23-28 ◽  
Author(s):  
Saadiyah A. Dhahir ◽  
◽  
Jinan H. Murtadha ◽  
Iman H. Abdul Razzaq ◽  
◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Aqueous Extract ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Origanum Vulgare

Cytotoxic Effect of Ink Extracted from Cephalopoda on Cancer Cell Line

2019 ◽  
Vol 03 (12) ◽  
pp. 139-145
Author(s):  
Israa H. Khudhair ◽  
Dhamia K. Suker ◽  
Balsam A. Hanna
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Cancer Cell Line
Sign in / Sign up

Export Citation Format

Share Document