Purification and characterization of protease enzyme from actinomycetes and its cytotoxic effect on cancer cell line (A549)

2012 ◽  
Vol 2 (2) ◽  
pp. S1138-S1146 ◽  
Author(s):  
C Balachandran ◽  
V Duraipandiyan ◽  
S Ignacimuthu
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Purification And Characterization ◽  
Protease Enzyme

Synthesis and Anticancer Activity of New Hydrazide-hydrazones and Their Pd(II) Complexes

2019 ◽  
Vol 16 (5) ◽  
pp. 522-532 ◽  
Author(s):  
Bedia Kocyigit-Kaymakcioglu ◽  
Senem Sinem Yazici ◽  
Fatih Tok ◽  
Miriş Dikmen ◽  
Selin Engür ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
A549 Cells ◽  
Cancer Cell Line ◽  
Fibroblast Cell ◽  
Reference Drug ◽  
A549 Cancer Cell Line

Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: 5-Chloro-N’-[(substituted)methylidene] pyrazine-2-carbohydrazide (3a-g) and their Pd(II) complexes (4a-h) were synthesized and investigated in vitro anticancer activity on A549, Caco2 cancer and normal 3T3 fibroblast cell lines, using the MTT assay. Results: Anticancer activity screening results revealed that some compounds showed remarkable cytotoxic effect. Among them, 5-chloro-N'-[(4-hydroxyphenyl)methylidene] pyrazine-2-carbohydrazide (3c) displayed higher cytotoxic activity against A549 cancer cell line than the reference drug cisplatin. Conclusion: Compound 3c showed high cytotoxic activity against A549 cancer cell line but it showed low cytotoxic effect against normal 3T3 fibroblast cell line. Antiproliferative and antimetastatic effects of 3c were determined by the real-time monitoring of cell proliferative system (RTCA DP). The cell proliferation, metastatic and invasive activities of A549 cells were decreased due to increased concentration of 3c.

Isolation and characterization of stem-like cells from a human ovarian cancer cell line

2011 ◽  
Vol 363 (1-2) ◽  
pp. 257-268 ◽  
Author(s):  
Lijuan Wang ◽  
Roman Mezencev ◽  
Nathan J. Bowen ◽  
Lilya V. Matyunina ◽  
John F. McDonald
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Isolation And Characterization

Establishment and Characterization of HKESC-1, a New Cancer Cell Line from Human Esophageal Squamous Cell Carcinoma

2000 ◽  
Vol 118 (2) ◽  
pp. 112-120 ◽  
Author(s):  
Ying-Chuan Hu ◽  
King Y Lam ◽  
Thomas S.K Wan ◽  
Wei-Gang Fang ◽  
Edmond S.K Ma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Cancer Cell ◽  
Squamous Cell ◽  
Cancer Cell Line

scholarly journals Establishment and Characterization of a Highly Tumorigenic African American Prostate Cancer Cell Line, E006AA-hT

2014 ◽  
Vol 10 (8) ◽  
pp. 834-845 ◽  
Author(s):  
Shahriar Koochekpour ◽  
Stacey S. Willard ◽  
Mojgan Shourideh ◽  
Shafat Ali ◽  
Chunhong Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line

Establishment and characterization of OCUT-1, an undifferentiated thyroid cancer cell line expressing high level of telomerase

2002 ◽  
Vol 80 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Kana Ogisawa ◽  
Naoyoshi Onoda ◽  
Tetsuro Ishikawa ◽  
Chiemi Takenaka ◽  
Masaaki Inaba ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cell Line ◽  
High Level ◽  
Undifferentiated Thyroid Cancer

Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor

2009 ◽  
Vol 53 (6) ◽  
pp. 1040-1047 ◽  
Author(s):  
Tina T.-L. Chen ◽  
Dinesh Rakheja ◽  
Jaclyn Y. Hung ◽  
Peter J. Hornsby ◽  
Piotr Tabaczewski ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Liver Tumor ◽  
Cancer Cell Line
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