Simultaneous UV Spectrophotometric Methods for Estimation of Paracetamol and Domperidone in Bulk and Tablet Dosage Form

2016 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
Audumbar Mali ◽  
Ankush Hake ◽  
Manoj Patil ◽  
Ritesh Bathe ◽  
Ashpak Tamboli
Keyword(s):  
Dosage Form ◽  
Spectrophotometric Methods ◽  
Tablet Dosage

Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form

2021 ◽  
pp. 6003-6006
Author(s):  
Pushpa Latha E. ◽  
Sailaja B.
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Limit Of Detection ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Form ◽  
Rizatriptan Benzoate ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Development And Validation ◽  
Tablet Dosage

Analytical UV derivative spectrophotometric method was developed and validated to quantify Rizatriptan Benzoate in pure drug and tablet dosage form. Based on the spectrophotometric characteristics of Rizatriptan Benzoate, a signal of zero (225nm), first (216nm), second (237nm), third (233nm), fourth (231nm) order derivative spectra were found to be adequate for quantification. The methods obeyed Beer's law in the concentration range of (0.1-360µg/ml) with square correlation coefficient (r2) of 0.999. The mean percentage recovery was found to be 100.01 ± 0.075. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.

scholarly journals Simultaneous Spectrophotometric Methods for Estimation of Cefpodoxime Proxetil and Potassium Clavulanate in Tablet Dosage form

2010 ◽  
Vol 9 (4) ◽  
pp. 167 ◽  
Author(s):  
A. B. Thomas ◽  
S. B. Dighe ◽  
L. P. Kothapalli ◽  
R. K. Nanda ◽  
S. N. Jagdale ◽  
...  
Keyword(s):  
Dosage Form ◽  
Cefpodoxime Proxetil ◽  
Spectrophotometric Methods ◽  
Potassium Clavulanate ◽  
Tablet Dosage

scholarly journals Spectrophometric Determination of Nelfinavir Mesylate

2006 ◽  
Vol 3 (2) ◽  
pp. 78-82 ◽  
Author(s):  
K. Vanitha Prakash ◽  
Jangala Venkateswara Rao
Keyword(s):  
Ferric Chloride ◽  
Dosage Form ◽  
Potassium Ferricyanide ◽  
Reagent Blank ◽  
Spectrophotometric Methods ◽  
Bluish Green ◽  
Nelfinavir Mesylate ◽  
Bulk Drug ◽  
Tablet Dosage

Two new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen. The Method B is based on the formation of blood red colored chromogen with Ferric chloride and 1,10-phenanthroline. The absorbances of the chromogen were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.

scholarly journals ANALYSIS ANALYSIS OF CAFFEINE IN TABLET DOSAGE FORM WITH SPECTROPHOTOMETRIC AND IODOMETRIC BACK TITRATION METHODS

2019 ◽  
Vol 4 (6) ◽  
pp. 271-280
Author(s):  
Edy Agustian Yazid
Keyword(s):  
Spectrophotometric Method ◽  
Active Ingredient ◽  
Dosage Form ◽  
Dosage Forms ◽  
Titration Method ◽  
Simple Apparatus ◽  
Spectrophotometric Methods ◽  
True Value ◽  
Back Titration ◽  
Tablet Dosage

Caffeine (1, 3, 5-trimethylxanthine) is an active ingredient that is often added to analgesics drugs to teat headaches or reduce pain. This study aims to quantitatively analyze caffeine levels in tablet dosage forms by spectrophotometric methods and iodometric back titration. In the spectrophotometric method the measurement of caffeine levels was carried out using a maximum wavelength of 272 nm.The results of caffeine levels were found for bodrex drugs (50.87 ± 0.195 mg/tab), extra panadol (64.92 ± 0.579 mg/tab), saridon (51.38 ± 0.273 mg/tab) and paramex (46.78 ± 0.072 mg/tab). The purity percentage of caffeine was found in the range between 93.57-102.76%. While the iodometric back titration method was obtained for bodrex (48.04 ± 0.889 mg/tab), extra panadol (64.45 ± 0.697 mg/tab), saridon (43.38 ± 0.756 mg/tab) and paramex (42.36 ± 0.889 mg/tab) with a purity range of 84.73-99.15%. The average caffeine content of the two method extant suitability close to the true value as stated on the label. The results of the spectrophotometric method are more accurate, while the titrimetry method is still good to use because it is cheaper and only requires simple apparatus and common chemicals.

scholarly journals Development and validation of analytical methods for the simultaneous estimation of Nimorazole and Ofloxacin in tablet dosage form

2016 ◽  
Vol 8 (3) ◽  
pp. 96
Author(s):  
A P Ghugare ◽  
Lalchand Dayanand Devhare ◽  
B P Hatwar
Keyword(s):  
Analytical Methods ◽  
Dosage Form ◽  
Simultaneous Equations ◽  
Simultaneous Estimation ◽  
Distilled Water ◽  
Spectrophotometric Methods ◽  
Ratio Equation ◽  
Absorbance Ratio ◽  
Development And Validation ◽  
Tablet Dosage

<p>Two simple, rapid, accurate and precise spectrophotometric methods have been developed for simultaneous estimation of Nimorazole and Ofloxacin from tablet dosage form. Method І involves formation of ‘simultaneous equations’ at 304 nm (λ max of Nimorazole) and 287.5 nm (λ max of Ofloxacin); while Method ІІ involves, formation of ‘Absorbance ratio equation’ at 301(isoabsorptive point) and 287.5 nm (λ max of Ofloxacin) using distilled water as a solvent. The linearity was observed in the concentration range of 5 - 25 μg/ml for Nimorazole and 2 - 10 μg/ml for Ofloxacin. The results of analysis have been validated statistically and by recovery studies and were found satisfactory.</p>

scholarly journals Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form

2019 ◽  
Vol 57 (3) ◽  
pp. 117
Author(s):  
Olajire Adegoke ◽  
Olusegun Thomas ◽  
Deborah Babatunde ◽  
Oyindamola Oyelami ◽  
Adeyinka Adediran ◽  
...  
Keyword(s):  
Dosage Form ◽  
Spectrophotometric Methods ◽  
Tablet Dosage

Simultaneous UV Spectrophotometric Methods for Estimation of Cefixime Trihydrate and Ofloxacin in Bulk and Tablet Dosage Form

2016 ◽  
Vol 6 (2) ◽  
pp. 100
Author(s):  
Audumbar Mali ◽  
Santosh Jadhav ◽  
Rahul Gorad ◽  
Aamer Quazi ◽  
Ritesh Bathe ◽  
...  
Keyword(s):  
Dosage Form ◽  
Spectrophotometric Methods ◽  
Tablet Dosage
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