scholarly journals Ambient air pollution and endocrinologic disorders in childhood

2021 ◽  
Vol 26 (3) ◽  
pp. 158-170
Author(s):  
You Joung Heo ◽  
Hae Soon Kim
Keyword(s):  
Air Pollution ◽  
Animal Studies ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Placental Development ◽  
Mortality And Morbidity ◽  
Epigenetic Modulation ◽  
Childhood Type 1 Diabetes ◽  
Study Designs ◽  
Pollution Exposure

Ambient air pollution has been proposed as an important environmental risk factor that increases global mortality and morbidity. Over the past decade, several human and animal studies have reported an association between exposure to air pollution and altered metabolic and endocrine systems in children. However, the results for these studies were mixed and inconclusive and did not demonstrate causality because different outcomes were observed due to different study designs, exposure periods, and methodologies for exposure measurements. Current proposed mechanisms include altered immune response, oxidative stress, neuroinflammation, inadequate placental development, and epigenetic modulation. In this review, we summarized the results of previous pediatric studies that reported effects of prenatal and postnatal air pollution exposure on childhood type 1 diabetes mellitus, obesity, insulin resistance, thyroid dysfunction, and timing of pubertal onset, along with underlying related mechanisms.

scholarly journals Differential Effect of Ambient Air Pollution Exposure on Risk of Gestational Hypertension and Preeclampsia

Hypertension ◽  
2019 ◽  
Vol 74 (2) ◽  
pp. 384-390 ◽  
Author(s):  
Carrie J. Nobles ◽  
Andrew Williams ◽  
Marion Ouidir ◽  
Seth Sherman ◽  
Pauline Mendola
Keyword(s):  
Air Pollution ◽  
Differential Effect ◽  
Gestational Hypertension ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Short-term effects of air pollution on blood pressure

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
You-Jung Choi ◽  
Sun-Hwa Kim ◽  
Si-Hyuck Kang ◽  
Sun-Young Kim ◽  
Ok-Jin Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Air Pollutants ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Pathophysiological Mechanism ◽  
Short Term ◽  
Mortality And Morbidity ◽  
Short Term Exposure ◽  
Increased Risk

AbstractElevated blood pressure (BP) has been proposed as a possible pathophysiological mechanism linking exposure to ambient air pollution and the increased risk of cardiovascular mortality and morbidity. In this study, we investigated the hourly relationship between ambient air pollutants and BP. BP measurements were extracted from the electronic health record database of the Seoul National University Bundang Hospital from February 2015 to June 2017. A total of 98,577 individual BP measurements were matched to the hourly levels of air pollutants. A generalized additive model was constructed for hour lags of 0–8 of air pollutants adjusting for age, sex, meteorological variables, and time trend. Systolic BP was shown to be significantly lower at 2–4 hours and 3–5 hours after increased levels of SO2 and CO, respectively (0.24 mmHg and 0.26 mmHg for an interquartile range, respectively). In contrast, O3 and NO2 were associated with significantly increased systolic BP at 3–5 lag hours and at 0–2 lag hours, respectively. BP elevation in association with O3 and NO2 was shown to be significantly greater in hypertensive patients than normotensive subjects. Our findings suggest that short-term exposure to air pollution may be associated with elevated BP.

scholarly journals Air pollution interventions and respiratory health: a systematic review

2020 ◽  
Vol 24 (2) ◽  
pp. 150-164 ◽  
Author(s):  
S. Saleh ◽  
W. Shepherd ◽  
C. Jewell ◽  
N. L. Lam ◽  
J. Balmes ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Respiratory Health ◽  
Grey Literature ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Potential Health ◽  
Exposure Reduction ◽  
Air Pollution Exposure ◽  
Pollution Exposure

BACKGROUND: Indoor and ambient air pollution exposure is a major risk to respiratory health worldwide, particularly in low- and middle-income countries (LMICs). Interventional trials have mainly focused on alternatives to cooking stoves, with mixed results. Beyond cooking, additional sources of particulate matter also contribute to the burden of air pollution exposure. This review explores evidence from current randomised controlled trials (RCTs) on the clinical effectiveness of interventions to reduce particulate matter in LMICs.METHODS: Twelve databases and the grey literature (e.g., Government reports and policy papers) were searched. Eligible studies were RCTs conducted in LMICs aiming to reduce particulate exposure from any source and reporting on at least one clinical respiratory outcome (respiratory symptoms, lung function or clinical diagnoses). Data from relevant studies were systematically extracted, the risk of bias assessed and narrative synthesis provided.RESULTS: Of the 14 included studies, 12 tested ‘improved' cookstoves, most using biomass, but solar and bioethanol cookers were also included. One trial used solar lamps and another was an integrated intervention incorporating behavioural and environmental components for the treatment and prevention of chronic obstructive pulmonary disease. Of the six studies reporting child pneumonia outcomes, none demonstrated significant benefit in intention-to-treat analysis. Ten studies reported respiratory symptom outcomes with some improvements seen, but self-reporting made these outcomes highly vulnerable to bias. Substantial inter-study clinical and methodological heterogeneity precluded calculation of pooled effect estimates.CONCLUSION: Evidence from the RCTs performed to date suggests that individual household-level interventions for air pollution exposure reduction have limited benefits for respiratory health. More comprehensive approaches to air pollution exposure reduction must be developed so their potential health benefits can be assessed.

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