scholarly journals Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis

2021 ◽  
Author(s):  
Semra ÖZKAN ÖZTÜRK ◽  
Hilmi ATASEVEN
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factor ◽  
Serum Levels ◽  
Chronic Hemodialysis

Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis

Metabolism ◽  
2009 ◽  
Vol 58 (4) ◽  
pp. 547-551 ◽  
Author(s):  
Thomas Ebert ◽  
Anette Bachmann ◽  
Ulrike Lössner ◽  
Jürgen Kratzsch ◽  
Matthias Blüher ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factor ◽  
Serum Levels ◽  
Chronic Hemodialysis

Abstract 1559: Increased Length Of Hospitalization And Weight Gain In Diabetic Patients Are Associated With induction of HIF1α expression and Higher serum Levels Of Permeability-inducing Growth Factors: Vegf, And Hgf

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Sirisha Emani ◽  
Basel Ramlawi ◽  
Neel Sodha ◽  
Cesario Bianchi ◽  
Frank Sellke
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Growth Factors ◽  
Weight Gain ◽  
Growth Factor ◽  
Protein Expression ◽  
Microarray Analysis ◽  
Serum Levels ◽  
Post Surgery ◽  
Length Of Hospitalization

Background- Inflammatory mediators such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) play a critical role in the regulation of vascular permeability, and angiogenesis. We studied the serum levels of several growth factors including VEGF, FGF, and HGF as well as gene expression profiles of genes involved in growth factor signaling in the peripheral blood of patients with diabetes mellitus (DM) and without diabetes mellitus (ND) following cardiopulmonary bypass (CPB) and cardioplegic arrest (C). Methods- Serum for evaluation of growth factors and total RNA for microarray analysis were obtained from the blood samples collected from DM patients (n=8) and matched ND patients (n=8) who underwent coronary artery bypass graft (CABG) or valve procedures; before (pre), 6 hours (6h), and 4 days (4d) after CPB/C. The cytokine panel consisting of growth factors such as VEGF, HGF, FGF, and EGF were quantified in DM and ND patients; pre, 6h, and 4d post-CPB/C using a multiplex cytokine quantification system. cDNA microarray analysis was performed using Affymetrix Genechip U133 plus 2.0 software to assess gene expression of 47,000 genes. Further validation of gene expression was performed by quantitative real-time PCR. Results- Length of hospitalization (9 vs. 6 days post-surgery; p=0.04) and weight gain (6 lbs vs. 2.4 lbs 4d post-surgery; p<0.01) were significantly greater for DM patients when compared to ND patients. VEGF, and HGF were elevated in DM and ND patients; 6h post-CBP/C. The serum levels of these cytokines were elevated significantly in DM patients when compared to ND patients; pre vs. 6h post-CPB/C. In correlation with VEGF protein expression, microarray analysis showed significantly elevated levels of HIF1α mRNA expression (> 4 fold), a critical regulator of hypoxia signaling, 4d after CPB/C exclusively in DM patients. Other transcription factors such as CREB and P300 that directly affect HIF1α expression were also significantly elevated only in DM patients (p<0.01). Conclusion- The unique pattern of gene and protein expression profile of growth factors and their related genes in DM vs. ND patients could be associated with increased edema and weight gain in DM patients after CPB/C.

Vitamin D Supplementation and Serum Levels of Magne-sium and Selenium in Type 2 Diabetes Mellitus Patients: Gender Dimorphic Changes

2014 ◽  
Vol 84 (1-2) ◽  
pp. 27-34 ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Khalid M. Alkharfy ◽  
Nasiruddin Khan ◽  
Hanan A. Alfawaz ◽  
Abdulrahman S. Al-Ajlan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Serum Selenium ◽  
Dependent Manner

The aim of our study was to evaluate the effects of vitamin D supplementation on circulating levels of magnesium and selenium in patients with type 2 diabetes mellitus (T2DM). A total of 126 adult Saudi patients (55 men and 71 women, mean age 53.6 ± 10.7 years) with controlled T2DM were randomly recruited for the study. All subjects were given vitamin D3 tablets (2000 IU/day) for six months. Follow-up mean concentrations of serum 25-hydroxyvitamin D [25-(OH) vitamin D] significantly increased in both men (34.1 ± 12.4 to 57.8 ± 17.0 nmol/L) and women (35.7 ± 13.5 to 60.1 ± 18.5 nmol/L, p < 0.001), while levels of parathyroid hormone (PTH) decreased significantly in both men (1.6 ± 0.17 to 0.96 ± 0.10 pmol/L, p = 0.003) and women (1.6 ± 0.17 to 1.0 ± 0.14 pmol/L, p = 0.02). In addition, there was a significant increase in serum levels of selenium and magnesium in men and women (p-values < 0.001 and 0.04, respectively) after follow-up. In women, a significant correlation was observed between delta change (variables at six months-variable at baseline) of serum magnesium versus high-density lipoprotein (HDL)-cholesterol (r = 0.36, p = 0.006) and fasting glucose (r = - 0.33, p = 0.01). In men, there was a significant correlation between serum selenium and triglycerides (r = 0.32, p = 0.04). Vitamin D supplementation improves serum concentrations of magnesium and selenium in a gender-dependent manner, which in turn could affect several cardiometabolic parameters such as glucose and lipids.

Serum levels of vitamin B12 in cobalamin deficient subjects with or without diabetes mellitus

2018 ◽  
Author(s):  
Duygu Nurdan Avci ◽  
Canan Ersoy ◽  
Soner Cander ◽  
Ozen Oz Gul ◽  
Pinar Sisman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin B12 ◽  
Serum Levels
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