scholarly journals Focusing on the Efficacy of Tizanidine in the Multiple Sclerosis Clinic

2001 ◽  
Vol 3 (1) ◽  
pp. 29-31
Author(s):  
Thomas F. Scott

ABSTRACT The use of tizanidine is well established in spasticity due to multiple sclerosis (MS), spinal cord injury, and cerebrovascular disease. Refinement of the use oftizanidine in these areas is ongoing. To date, most large studies have focused primarily on measurement of changes in abnormalities of tone and spasm frequency rather than changes related to improved function. More detailed studies may help to better elucidate the impact of tizanidine and other spasticity treatments on activities of daily living and overall quality of life of MS patients. (Int J MS Care. 2001; 3(1): 29–31)

There are several hundred neurological conditions, some more commonly occurring than others. NHS England categorizes them into sudden-onset conditions resulting from an acquired or traumatic brain or spinal cord injury; progressive deteriorating conditions such as Alzheimer’s disease, dementia, and motor neurone disease; and other conditions that might have a more fluctuating pathway such as epilepsy, Parkinson’s disease, or multiple sclerosis. Most of these conditions result in varying degrees of disability that demand considerable personal and NHS resources to improve independence and the quality of life for these people.


2012 ◽  
Vol 17 (Suppl1) ◽  
pp. 29-37 ◽  
Author(s):  
Maxwell Boakye ◽  
Barbara C. Leigh ◽  
Andrea C. Skelly

Object The aim of this study was to identify the quality of life (QOL) measures commonly used to assess patients with spinal cord injury (SCI) and to summarize studies using common QOL measures that have been validated in SCI populations to compare scores in persons with SCI with those in a control population. Methods A systematic search of PubMed was conducted to identify studies using common QOL measures in persons with SCI and those comparing scores for QOL measures in an SCI population with scores in other populations. The authors sought comparative studies utilizing QOL measures for which validity and reliability analyses had been done. Results Of 28 QOL measures found, validity and reliability studies had been conducted in patients with SCI for 5 measures. Twelve comparative studies compared QOL in SCI patients with QOL in healthy controls or in patients with other disabilities, or with normative data. The 36-Item Short Form Health Survey (SF-36) and the short version of the WHOQOL (WHOQOL-BREF) were the most widely used QOL instruments. Patients with SCI had a decreased QOL as compared with that in healthy controls or normative data, with the most pronounced deficits in the domains of physical functioning and physical role limitations. In 3 studies, patients with tetraplegia had a lower physical domain QOL than did those with paraplegia. Overall, however, the impact of injury level and injury completeness on QOL after SCI remains unclear due to a lack of longitudinal studies. Conclusions The SF-36 and WHOQOL-BREF are validated instruments that should be considered for use in SCI QOL studies. Future analysis of deficits in QOL among patients with SCI would benefit from the development of a QOL instrument specifically targeted to SCI. Longitudinal studies to assess the impact of injury level and injury completeness on SCI QOL are also needed.


2012 ◽  
Vol 34 (15) ◽  
pp. 1284-1290 ◽  
Author(s):  
Mirjana Jovanović ◽  
Mira Lakićević ◽  
Dejan Stevanović ◽  
Vedrana Milić-Rasić ◽  
Svetlana Slavnić

2018 ◽  
Vol 21 (3) ◽  
pp. 126-132
Author(s):  
Cemile Sevgi POLAT ◽  
Didem Sezgin ÖZCAN ◽  
Belma Füsun KÖSEOĞLU ◽  
Hilmi Umut TATLI ◽  
Şule ŞAHİN ONAT

Author(s):  
Agata Goraczko ◽  
Alina Zurek ◽  
Maciej Lachowicz ◽  
Katarzyna Kujawa ◽  
Grzegorz Zurek

Background: The present investigation was designed to determine cognitive performance and quality of life (QoL) in a group of elite athletes who sustained spinal cord injury (SCI). Methods: nine participants suffering a SCI participated in the study. Different cognitive functions were evaluated through the following tests: COWAT, Digit Span, Stroop color–word and QoL through the WHOQoL-BREF scale. Results: Generally, participants positively assessed their overall quality of life and health status. Although the tests conducted indicate reduced cognitive function among the athletes, it did not affect the reduction in QoL. Single correlations between the results of cognitive tests and QoL could be treated as coincidental. Conclusions: Despite the observed decline in selected cognitive functions, the participants positively assessed their quality of life and physical health.Reduced cognitive functioning could be influenced by the impact of sleep-disordered breathing, pain, depressive disorders and medication. This indicates the need for an individualized approach to define the patient’s deficits, needs and best care. Further studies with a larger group of participants are needed.


Author(s):  
Nguyen Le Bao Tien ◽  
Vo Van Thanh ◽  
Khuc Thi Hong Hanh ◽  
Pham Gia Anh ◽  
Le Thi Minh Huyen ◽  
...  

Spinal cord injury (SCI) is defined as temporary or permanent changes in spinal cord function and reflex activity. The objective of this study is to evaluate health-related quality of life (HRQoL) and activities of daily living (ADL) among postoperative surgery patients with complete cervical SCI in Vietnam and to explore the factors associated with these indices. A cross-sectional study was conducted on 88 adults in Vietnam from June 2018 to June 2019. The EQ-5D-5L, ADL, and instrumental activities of daily living (IADL) were applied. Multivariate Tobit regression was adopted to determine factors that were associated with HRQOL, ADL, and IADL. Results: Participants who were in American Spinal Cord Injury Association (ASIA) scale group A (ASIA-A) had the lowest ADL, IADL index, and HRQOL score (p < 0.001). HRQoL and ADL were affected by health insurance coverage, occupation, type of fracture, and IADL. Meanwhile, IADL was significantly associated with living areas and ASIA. Low HRQoL among patients suffering from SCI was observed. Attention should be given to outcomes related to a disability during clinical treatment and should be treated effectively in the recovery.


2018 ◽  
Vol 22 (9) ◽  
pp. 1662-1672 ◽  
Author(s):  
D. Burke ◽  
O. Lennon ◽  
B.M. Fullen

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