scholarly journals Assessment of Cellular Proliferation in Oral Verrucous Carcinoma and Well-Differentiated Oral Squamous Cell Carcinoma Using Ki67: A Non-Reliable Factor for Differential Diagnosis?

2012 ◽  
Vol 13 (11) ◽  
pp. 5811-5815 ◽  
Author(s):  
Massoumeh Zargaran ◽  
Nosratollah Eshghyar ◽  
Fahimeh Baghaei ◽  
Abbas Moghimbeigi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cellular Proliferation ◽  
Verrucous Carcinoma ◽  
Well Differentiated

scholarly journals Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)

Tumor Biology ◽  
2010 ◽  
Vol 32 (2) ◽  
pp. 409-416 ◽  
Author(s):  
José Vieira de Spíndula-Filho ◽  
Aparecido Divino da Cruz ◽  
Angélica Ferreira Oton-Leite ◽  
Aline Carvalho Batista ◽  
Cláudio Rodrigues Leles ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cellular Proliferation ◽  
Verrucous Carcinoma ◽  
Negative Relation

scholarly journals Oral carcinoma cuniculatum: an unacquainted entity with diagnostic challenges—a case report

2022 ◽  
Vol 34 (1) ◽  
Author(s):  
Safaa Baz ◽  
Hatem Wael Amer ◽  
Ali A. Wahed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Oral Carcinoma ◽  
Diagnostic Features ◽  
Papillary Squamous Cell Carcinoma ◽  
Well Differentiated ◽  
Carcinoma Cuniculatum

Abstract Background Oral carcinoma cuniculatum (OCC) is an unacquainted well-differentiated subtype of oral squamous cell carcinoma, which displays unique clinic-pathological features. Up to date, OCC remains rare with about 75 reported cases, and is frequently missed or even misdiagnosed. Case presentation The aim of the present work was: to report a case of OCC in mandibular gingiva and to highlight its main clinic-pathological diagnostic features: with an exophytic cobble-stone surface and a characteristic endophytic burrowing architecture, as well as to differentiate between it and other closely similar lesions including verrucous carcinoma, papillary squamous cell carcinoma, and well-differentiated conventional oral squamous cell carcinoma. Conclusions An accurate diagnosis of OCC entails awareness of the clinicians and pathologists about its entity, proper knowledge of the diagnostic clinical and histopathological evidence, and the ability to differentiate it from closely similar lesions.

Upregulated histone deacetylase 2 gene correlates with the progression of oral squamous cell carcinoma

2020 ◽  
Vol 29 (4) ◽  
pp. 543-552
Author(s):  
Akhilesh Krishna ◽  
Vineeta Singh ◽  
Shraddha Singh ◽  
Sachil Kumar ◽  
Vijay Kumar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Level ◽  
Histone Deacetylases ◽  
Cellular Proliferation ◽  
Mrna Levels ◽  
Histone Deacetylase 2

BACKGROUND: Histone deacetylases (HDACs) are considered as an essential regulator of cellular proliferation, differentiation, and apoptosis. The HDAC2 enzyme of Class I HDACs plays an important role in tumor progression of human malignancies. OBJECTIVE: The aim of the present study was to analyze the HDAC2 gene expression in pre-oral cancer and oral squamous cell carcinoma (OSCC), and its association with clinico-pathological features. METHODS: The HDAC2 protein expression was analyzed through the immunohistochemistry and western blot techniques in 82 oral pre-malignant, 90 OSCC, and 16 normal control tissues. qRT-PCR was used to quantify the mRNA fold change in all groups. RESULTS: The HDAC2 protein and mRNA levels were significantly higher in OSCC and pre-oral cancer groups compared to the controls. Immunostaining of HDAC2 protein was enhanced in 84.4% of OSCC and 67.1% of pre-cancerous tissue sections (p< 0.01). The mean protein level was analyzed as 1.96 ± 0.44 in oral carcinoma, 1.61 ± 0.39 in pre-cancer and 0.96 ± 0.10 in control tissues. In addition, HDAC2 mean protein level was associated with histological differentiation (OR = 25, p< 0.05) and tumor-node-metastasis (TNM) stages (OR = 6.2, p< 0.05) of OSCC patients. CONCLUSIONS: The upregulated HDAC2 gene in pre-cancer and OSCC tissues indicates its crucial role in the transformation of pre-malignant to malignant carcinoma. It could be a potential cancer biomarker of prognosis and targeted therapy in OSCC.

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