scholarly journals Impact of Cellular Immune Function on Prognosis of Lung Cancer Patients after Cytokine-induced Killer Cell Therapy

2014 ◽  
Vol 15 (15) ◽  
pp. 6009-6014 ◽  
Author(s):  
Congguo Jin ◽  
Jia Li ◽  
Yeying Wang ◽  
Xiaoqun Chen ◽  
Yanhua Che ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Therapy ◽  
Immune Function ◽  
Cancer Patients ◽  
Killer Cell ◽  
Cellular Immune Function ◽  
Lung Cancer Patients ◽  
Cellular Immune

Autologous cytokine-induced killer cell therapy in lung cancer patients: A retrospective study

2015 ◽  
Vol 70 ◽  
pp. 248-252 ◽  
Author(s):  
Jinying Zhang ◽  
Lingjun Zhu ◽  
Haina Du ◽  
Xiang He ◽  
Yongmei Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retrospective Study ◽  
Cell Therapy ◽  
Cancer Patients ◽  
Killer Cell ◽  
Lung Cancer Patients

scholarly journals A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy

2010 ◽  
Vol 101 (11) ◽  
pp. 2333-2340 ◽  
Author(s):  
Kohsuke Okita ◽  
Shinichiro Motohashi ◽  
Ryo Shinnakasu ◽  
Kaoru Nagato ◽  
Kazuki Yamasaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cell ◽  
Cell Therapy ◽  
Cancer Patients ◽  
Interferon Γ ◽  
Lung Cancer Patients ◽  
Dendritic Cell Therapy

Sense of coherence in lung cancer patients: Association with coping, immune function, and fatigue

2017 ◽  
Vol 66 ◽  
pp. e25
Author(s):  
C. Siwik ◽  
W. Rebholz ◽  
K. Phillips ◽  
E. Cash ◽  
F.S. Dhabhar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune Function ◽  
Cancer Patients ◽  
Sense Of Coherence ◽  
Lung Cancer Patients

Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients

2018 ◽  
Vol 67 (8) ◽  
pp. 1221-1230 ◽  
Author(s):  
Ronny Ben-Avi ◽  
Ronit Farhi ◽  
Alon Ben-Nun ◽  
Marina Gorodner ◽  
Eyal Greenberg ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Therapy ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Adoptive Cell Therapy ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Infiltrating Lymphocytes

Targeting CD38 to improve anti-PD-1/CTLA-4 combination therapy in lung cancer.

2018 ◽  
Vol 36 (5_suppl) ◽  
pp. 144-144 ◽  
Author(s):  
Limo Chen ◽  
Yanli Li ◽  
Xiaohui Yi ◽  
Don Lynn Gibbons
Keyword(s):  
Lung Cancer ◽  
Tumor Microenvironment ◽  
Combination Therapy ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Primary Resistance ◽  
Lung Cancer Patients ◽  
Cd38 Expression ◽  
Pathologic Analysis ◽  
Cellular Immune

144 Background: The combination of anti-PD-1 and anti-CTLA-4 is a promising strategy that is being clinically explored to treat a variety of cancer types. Some patients display primary resistance to this combination treatment, while others relapse after treatment. Although some cancer patients have long-term durable responses to the combination therapy of anti-PD-1 and anti-CTLA-4, physicians have been looking for biomarkers that predict response. Methods: Using multiple immunocompetent syngeneic and K-rasLA1/+p53R172H?g/+ spontaneous animal models of lung cancer, we have explored the mechanisms of resistance to anti-PD-1/CTLA-4 combination therapy by evaluating the molecular and cellular immune profiles of the tumor microenvironment. Antibody-mediated cell depletion assays were also conducted to validate the mechanisms. Lastly, to determine the applicability to patients, we analyzed 791 lung cancer patients’ specimens with immunohistochemistry staining and mined many immune markers in multiple large independent patient databases (~1900 tumors). Results: We observed that tumor bearing mice treated with combined PD-1 and CTLA-4 blocking antibodies developed resistance through the up-regulation of CD38, and that targeting CD38 abolished the resistance in a manner dependent on B7-costimulation. Additionally, combined PD-1 and CTLA-4 blockade eradicates CD38-deficient tumors in mice. Further study revealed that control of tumors by triple blockade of CD38, PD-1, and CTLA-4 depended on improved functionality of CD4+/CD8+ TILs, which were reactivated by enriched CD103+ dendritic cells in the tumor microenvironment. Pathologic analysis revealed positive immunohistochemical staining for CD38 on tumor cells in 15-23% of cases and bioinformatic analyses revealed a strong correlation between CD38 expression and an immune inflammatory signature. Conclusions: Targeting CD38 improves the efficacy of anti-PD-1/CTLA-4 combination therapy in lung cancer. CD38 on tumor cells could potentially serve as a novel biomarker of resistance for immune checkpoint inhibition.

Natural Killer Cell Activity in Lung Cancer Patients

CHEST Journal ◽  
1987 ◽  
Vol 92 (6) ◽  
pp. 1022-1024 ◽  
Author(s):  
Ching-Chi Lin ◽  
Yuh-Chi Kuo ◽  
Wen-Chu Huang ◽  
Ching-Yuang Lin
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cancer Patients ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Lung Cancer Patients ◽  
Killer Cell Activity

scholarly journals Effects of magnanimous therapy on emotional, psychosomatic and immune functions of lung cancer patients

2020 ◽  
pp. 135910531990131
Author(s):  
Xuewei Huang ◽  
Qianyu Liu ◽  
Wendy Wen Li ◽  
Lanlan Wu ◽  
Anni Yan
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Killer Cell ◽  
Depression Scale ◽  
Advanced Lung Cancer ◽  
Controlled Study ◽  
Immune Functions ◽  
Lung Cancer Patients ◽  
Cell Functions ◽  
The Individual

This study was a randomised controlled study on the effects of the individual computer magnanimous therapy and group computer magnanimous therapy on emotional, psychosomatic and immune function among advanced lung cancer patients. Patients were examined at baseline and 2 weeks later using the Psychosomatic Status Scale for Cancer Patients, Hospital Anxiety Depression Scale and IgA, IgG, IgM and natural killer cell functions. The results showed that individual computer magnanimous therapy and group computer magnanimous therapy were beneficial for advanced lung cancer patients in improving depression, anxiety, psychosomatic status and immune functions. The improvements of immune functions may be related to the improvements of the participants’ emotional and psychosocial status.

Analyses on the Clinical Usefulness of Natural Killer Cell Activity in Non-Small Cell Lung Cancer Patients

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A663
Author(s):  
Sue In Choi ◽  
Kwnag Ho In ◽  
Kyung Ho Kang ◽  
Jae Jeong Shim ◽  
Chol Shin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cell ◽  
Cancer Patients ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Killer Cell Activity

Cellular Immune Response to Anaerobic Exercise among Gymnasts and Untrained Girls

1998 ◽  
Vol 10 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Baruch Wolach ◽  
Bareket Falk ◽  
Einat Kodesh ◽  
Judith Radnay ◽  
Hava Shapiro ◽  
...  
Keyword(s):  
Immune Function ◽  
Killer Cell ◽  
Anaerobic Exercise ◽  
Cellular Immune Function ◽  
Leukocyte Number ◽  
Baseline Values ◽  
Exercise Induced ◽  
Cellular Immune ◽  
Female Gymnasts ◽  
Induced Changes

The purpose of the present study was to investigate the effect of anaerobic exercise on aspects of cellular immune function among 10–12-year-old highly trained female gymnasts (n = 7) compared with age- and maturity-matched untrained girls (n = 6). Blood samples were drawn before, immediately after, and 24 hr following exercise. Leukocyte number, particularly neutrophils and lymphocytes, increased following 30 s of supramaximal exercise and returned to baseline values following 24 hr in both groups. Total T-cell and B-cell concentrations, as well as T-helper (CD4) and T-suppressor (CD8) number increased immediately after exercise and decreased following 24 hr in both groups. The CD4:CD8 ratio was reduced following exercise mainly due to an increase in CD8. Natural killer cell count was elevated following exercise and continued to be elevated 24 hr following exercise in both groups. In summary, the exercise-induced changes in cellular immune function among both groups were similar to changes described in adults.

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