Cellular Immune Response to Anaerobic Exercise among Gymnasts and Untrained Girls

1998 ◽  
Vol 10 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Baruch Wolach ◽  
Bareket Falk ◽  
Einat Kodesh ◽  
Judith Radnay ◽  
Hava Shapiro ◽  
...  
Keyword(s):  
Immune Function ◽  
Killer Cell ◽  
Anaerobic Exercise ◽  
Cellular Immune Function ◽  
Leukocyte Number ◽  
Baseline Values ◽  
Exercise Induced ◽  
Cellular Immune ◽  
Female Gymnasts ◽  
Induced Changes

The purpose of the present study was to investigate the effect of anaerobic exercise on aspects of cellular immune function among 10–12-year-old highly trained female gymnasts (n = 7) compared with age- and maturity-matched untrained girls (n = 6). Blood samples were drawn before, immediately after, and 24 hr following exercise. Leukocyte number, particularly neutrophils and lymphocytes, increased following 30 s of supramaximal exercise and returned to baseline values following 24 hr in both groups. Total T-cell and B-cell concentrations, as well as T-helper (CD4) and T-suppressor (CD8) number increased immediately after exercise and decreased following 24 hr in both groups. The CD4:CD8 ratio was reduced following exercise mainly due to an increase in CD8. Natural killer cell count was elevated following exercise and continued to be elevated 24 hr following exercise in both groups. In summary, the exercise-induced changes in cellular immune function among both groups were similar to changes described in adults.

scholarly journals Impact of Cellular Immune Function on Prognosis of Lung Cancer Patients after Cytokine-induced Killer Cell Therapy

2014 ◽  
Vol 15 (15) ◽  
pp. 6009-6014 ◽  
Author(s):  
Congguo Jin ◽  
Jia Li ◽  
Yeying Wang ◽  
Xiaoqun Chen ◽  
Yanhua Che ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Therapy ◽  
Immune Function ◽  
Cancer Patients ◽  
Killer Cell ◽  
Cellular Immune Function ◽  
Lung Cancer Patients ◽  
Cellular Immune

scholarly journals Marital distress prospectively predicts poorer cellular immune function

2013 ◽  
Vol 38 (11) ◽  
pp. 2713-2719 ◽  
Author(s):  
Lisa M. Jaremka ◽  
Ronald Glaser ◽  
William B. Malarkey ◽  
Janice K. Kiecolt-Glaser
Keyword(s):  
Immune Function ◽  
Marital Distress ◽  
Cellular Immune Function ◽  
Cellular Immune

Exercise-induced changes in immune function: effects of zinc supplementation

1994 ◽  
Vol 76 (6) ◽  
pp. 2298-2303 ◽  
Author(s):  
A. Singh ◽  
M. L. Failla ◽  
P. A. Deuster
Keyword(s):  
Immune Function ◽  
Zinc Supplementation ◽  
Thymidine Incorporation ◽  
Phase 1 ◽  
Antioxidant Effect ◽  
Oxygen Species ◽  
Respiratory Burst Activity ◽  
Double Blind ◽  
Exercise Induced ◽  
Induced Changes

To examine the effect of zinc (Zn) supplementation on exercise-induced changes in immune function, five male runners were randomly assigned in a double-blind crossover design to take a supplement (S; 25 mg of Zn and 1.5 mg of copper) or placebo (P) twice daily for 6 days. On morning 4 of each phase, 1 h after taking S or P, subjects ran on a treadmill at 70–75% of maximal oxygen uptake until exhaustion (approximately 2 h). Blood samples were obtained before (Pre), immediately after (Post), and 1 (Rec1) and 2 (Rec2) days after the run. [3H]thymidine incorporation by mitogen-treated mononuclear cell cultures was significantly lower (P < 0.05) Post than Pre, Rec1, or Rec2 for both S and P. Respiratory burst activity of isolated neutrophils was enhanced after exercise with P but not with S (P: Pre 12.0 +/- 1.1 vs. Post 17.6 +/- 2.3 nmol O2-/10(6) cells; S: Pre 11.7 +/- 0.3 vs. Post 12.1 +/- 1.2 nmol O2-/10(6) cells). Thus supplemental Zn blocked the exercise-induced increase in reactive oxygen species. Whether this antioxidant effect of Zn will benefit individuals exposed to chronic physical stress remains to be determined.

Effect of Hypertonic Saline Infusion on Postoperative Cellular Immune Function

2004 ◽  
Vol 100 (5) ◽  
pp. 1108-1118 ◽  
Author(s):  
Jens A. Kølsen-Petersen ◽  
Jens-Ole D. Nielsen ◽  
Else M. Tonnesen
Keyword(s):  
Immune Response ◽  
Immune Function ◽  
Hypertonic Saline ◽  
Cellular Immune Response ◽  
Killer Cell ◽  
Cell Activity ◽  
Abdominal Hysterectomy ◽  
Delayed Type Hypersensitivity ◽  
Laboratory Animals ◽  
Cellular Immune

Background Previous studies found hypertonicity to affect immune responses in intact laboratory animals and in human blood cell cultures. In this study, the authors investigated the cellular immune response to surgery after preoperative infusion of hypertonic saline in humans. Methods Sixty-two women scheduled to undergo abdominal hysterectomy were randomly assigned to single-blinded infusion of 4 ml/kg NaCl, 7.5%; 4 ml/kg NaCl, 0.9%; or 32 ml/kg NaCl, 0.9%, over 20 min. Blood was collected at baseline, during surgery, and 1, 24, and 48 h after surgery for the determination of leukocyte and differential counts, flow cytometric phenotyping of mononuclear cells, and natural killer cell activity against K 562 tumor cells. Phytohemagglutinin-induced lymphocyte proliferation, plasma elastase, and neutrophil chemotaxis were measured at the same time points except during surgery. The authors tested cell-mediated immune function in vivo by delayed-type hypersensitivity reaction in the skin. Results Surgery induced well-known changes in the cellular immune response, which were unrelated to the tonicity or volume of the infused fluids. Conclusion Infusion of a clinically relevant dose of hypertonic saline did not seem to modify the postoperative cellular immune response after elective abdominal hysterectomy.

scholarly journals Immunologic and clinical effects of repeated blood exchange in familial erythrophagocytic lymphohistiocytosis

Blood ◽  
1982 ◽  
Vol 60 (4) ◽  
pp. 814-821 ◽  
Author(s):  
S Ladisch ◽  
W Ho ◽  
D Matheson ◽  
R Pilkington ◽  
G Hartman
Keyword(s):  
Immune Function ◽  
Inhibitory Activity ◽  
Clinical Effects ◽  
Cellular Immune Function ◽  
Susceptibility To Infection ◽  
Blood Exchange ◽  
Cellular Immunodeficiency ◽  
Cellular Immune ◽  
Immune Defects

Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated plasma or blood exchange would decrease plasma inhibitory activity and improve cellular immune function in FEL. Following this treatment, reduction in plasma inhibitory activity, reversal of depressed antigen-specific lymphocyte proliferative responses and monocyte antibody-dependent cytotoxic function in vitro, and clinical improvement were complete in two and partial in one of three patients studied. Relapse, which was ultimately fatal, was associated with recurrence of the immune defects. These findings suggest that cellular immunodeficiency in FEL is acquired and possibly related to circulating immunosuppressive activity, the removal of which is associated with transient immunologic and clinical recovery.

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