Diagnostic Values of Serum Levels of Pepsinogens and Gastrin-17 for Screening Gastritis and Gastric Cancer in a High Risk Area in Northern Iran

Helicobacter pylori (Hp) is the major recognized risk factor for non-cardia gastric cancer (GC), but only a fraction of infected subjects develop GC, thus GC risk might reflect other genetic/environmental cofactors and/or differences in virulence among infectious Hp strains. Focusing on a high GC risk area of Northern Italy (Cremona, Lombardy) and using archived paraffin-embedded biopsies, we investigated the associations between the Hp vacA and cagA genotype variants and gastric intraepithelial neoplasia (GIN, 33 cases) versus non-neoplastic gastroduodenal lesions (NNGDLs, 37 cases). The glmM gene and the cagA and vacA (s and m) genotypes were determined by polymerase chain reaction (PCR) and sequencing. Hp was confirmed in 37/37 (100%) NNGDLs and detected in 9/33 GINs (27%), consistently with the well-known Hp loss in GC. CagA was detected in 4/9 Hp-positive GINs and in 29/37 NNGDLs. The vacA s1a and m1 subtypes were more common in GINs than in NNGDLs (6/7 vs. 12/34, p=0.014, for s1a; 7/7 vs. 18/34, p=0.020 for m1), with significant vacA s genotype-specific variance. The GIN-associated vacA s1a sequences clustered together, suggesting that aggressive Hp strains from a unique founder contribute to GC in the high-risk area studied.

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Mutagenic substances in red and white wine in Chile, a high risk area for gastric cancer

Mutation Research/Genetic Toxicology ◽

10.1016/0165-1218(87)90077-2 ◽

1987 ◽

Vol 187 (3) ◽

pp. 113-117 ◽

Cited By ~ 9

Author(s):

P. Bull ◽

L. Yanez ◽

F. Nervi

Keyword(s):

Gastric Cancer ◽

High Risk ◽

White Wine ◽

Risk Area ◽

High Risk Area

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Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study

Yearbook of Pediatrics ◽

10.1016/s0084-3954(09)79573-9 ◽

2011 ◽

Vol 2011 ◽

pp. 464-466

Author(s):

J.A. Stockman

Keyword(s):

High Risk ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Risk Area ◽

Northern Iran ◽

High Risk Area ◽

Drinking Habits ◽

Tea Drinking ◽

Control Study

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Trends in the Incidence of Stomach Cancer in Golestan Province, a High-risk Area in Northern Iran, 2004–2016

Archives of Iranian Medicine ◽

10.34172/aim.2020.28 ◽

2020 ◽

Vol 23 (6) ◽

pp. 362-368

Author(s):

Fatemeh Ghasemi-Kebria ◽

Taghi Amiriani ◽

Abdolreza Fazel ◽

Mohammad Naimi-Tabiei ◽

Alireza Norouzi ◽

...

Keyword(s):

High Risk ◽

Population Size ◽

Stomach Cancer ◽

Population Aging ◽

Incidence Rates ◽

High Risk Population ◽

Risk Area ◽

Northern Iran ◽

High Risk Area ◽

Golestan Province

Background: We aimed to present the temporal and geographical trends in the incidence of stomach cancer in the Golestan province, a high-risk area in Northern Iran. Methods: This study was conducted on stomach cancer cases registered in the Golestan Population-based Cancer Registry (GPCR) during 2004-2016. Age-standardized incidence rates (ASRs) per 100000 person-years were calculated. The Joinpoint regression analysis was used to calculate the average annual percent changes (AAPC). We also calculated the contribution of population aging, population size and risk to the overall changes in incidence rates. Results: Overall, 2964 stomach cancer patients were registered. The ASR of stomach cancer was significantly higher in men (26.9) than women (12.2) (P<0.01). There was a significant decreasing trend in incidence of stomach cancer in men (AAPC=-1.80, 95% CI: -3.30 to-0.28; P=0.02). We found a higher ASR of stomach cancer in the rural (21.4) than urban (18.1) (P=0.04) population, as well as a significant decreasing trend in its rates (AAPC=-2.14, 95% CI: -3.10to-1.17; P<0.01). The number of new cases of stomach cancer increased by 22.33% (from 215 in 2004 to 263 in 2016), of which 18.1%, 25.1% and -20.9% were due to population size, population aging and risk, respectively. Our findings suggest a higher rate for stomach cancer in eastern areas. Conclusion: We found high incidence rates as well as temporal and geographical diversities in ASR of stomach cancer in Golestan, Iran. Our results showed an increase in the number of new cases, mainly due to population size and aging. Further studies are warranted to determine the risk factors of this cancer in this high-risk population.

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