scholarly journals Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

2014 ◽  
Vol 15 (7) ◽  
pp. 2951-2957 ◽  
Author(s):  
Xiong-Fei Pan ◽  
Ying Wen ◽  
Marie Loh ◽  
Yuan-Yuan Wen ◽  
Shu-Juan Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Interleukin 4 ◽  
Southwestern China

Role of Xenobiotic-Metabolizing Enzyme Gene Polymorphisms and Interactions with Environmental Factors in Susceptibility to Gastric Cancer in Kashmir Valley

2009 ◽  
Vol 40 (1-2) ◽  
pp. 26-32 ◽  
Author(s):  
Manzoor A. Malik ◽  
Rohit Upadhyay ◽  
Rama D. Mittal ◽  
Showket A. Zargar ◽  
Dinesh R. Modi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Environmental Factors ◽  
Gene Polymorphisms ◽  
Kashmir Valley ◽  
Enzyme Gene ◽  
Metabolizing Enzyme

scholarly journals Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea

2012 ◽  
Vol 83 (1) ◽  
pp. 7 ◽  
Author(s):  
Eun-Young Kim ◽  
Hyung-Min Chin ◽  
Seung-Man Park ◽  
Hae-Myung Jeon ◽  
Woo-Chul Chung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Genetic Polymorphisms of CXCL8 (−251) Are Associated with the Susceptibility of Helicobacter pylori Infection Increased the Risk of Inflammation and Gastric Cancer in Thai Gastroduodenal Patients

2019 ◽  
Author(s):  
Wongwarut Boonyanugomol ◽  
Kamolchanok Rukseree ◽  
Worrarat Kongkasame ◽  
Prasit Palittapongarnpim ◽  
Seung-Chul Baik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Progression ◽  
Chemokine Receptor ◽  
Gene Polymorphisms ◽  
Inflammatory Responses ◽  
Increased Risk ◽  
Cxc Chemokine ◽  
H Pylori

CXC Chemokine Ligand 8 (CXCL8) plays an important role in gastric inflammation and in the progression of gastric cancer induced by Helicobacter pylori (H. pylori) infection. The association of CXCL8, CXC Chemokine Receptor 1 (CXCR1), and CXC Chemokine Receptor 2 (CXCR2) polymorphisms with H. pylori infection and gastric cancer progression needs to be investigated in a population within an enigma area consisting of multiple ethnicities, such as Thailand. To analyze the relative risk of H. pylori infection and gastric cancer among Thai gastroduodenal patients, gene polymorphisms in CXCL8 (promoter region -251) and in CXCR1 and CXCR2 (receptors for CXCL8) were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele specific-PCR (AS-PCR). We also determined the presence of cytotoxin-associated gene A (cagA) in Thai patients with H. pylori infection. Correlation between the CXCL8 (-251) polymorphism and CXCL8 gene expression was evaluated by quantitative reverse transcriptase-PCR (qRT-PCR). We found a significant association between the T/A and A/A genotypes of CXCL8 (-251) with H. pylori infection. However, no significant correlation was found between the CXCR1 (+2607) and CXCR2 (+1208) gene polymorphisms with H. pylori infection among Thai gastroduodenal subjects. Within the H. pylori-infected group of Thai gastroduodenal patients, no significant differences in cagA were observed. In addition, the A/A genotype of CXCL8 (-251) significantly correlated with the risk of gastric cancer and correlated with higher CXCL8 gene expression levels in Thai gastroduodenal patients. These results suggest that CXCL8 (-251) polymorphisms are associated with H. pylori infection, an increased risk of stronger inflammatory responses, and gastric cancer in Thai gastroduodenal patients.  

GSTT1 andGSTM1 gene polymorphisms and gastric cancer in a high-risk italian population

2005 ◽  
Vol 115 (2) ◽  
pp. 284-289 ◽  
Author(s):  
Domenico Palli ◽  
Calogero Saieva ◽  
Simonetta Gemma ◽  
Giovanna Masala ◽  
Maria Jesus Gomez-Miguel ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Gene Polymorphisms ◽  
Italian Population

scholarly journals Associations of NR5A2 Gene Polymorphisms with the Clinicopathological Characteristics and Survival of Gastric Cancer

2014 ◽  
Vol 15 (12) ◽  
pp. 22902-22917 ◽  
Author(s):  
Xunlei Zhang ◽  
Dongying Gu ◽  
Mulong Du ◽  
Meilin Wang ◽  
Chunxiang Cao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Clinicopathological Characteristics

scholarly journals A Pipeline to Call Multilevel Expression Changes between Cancer and Normal Tissues and Its Applications in Repurposing Drugs Effective for Gastric Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Wei Gao ◽  
Jianwei Yang ◽  
Changhua Zhuo ◽  
Sha Huang ◽  
Jinyuan Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Interleukin 4 ◽  
Data Quality Control ◽  
Expression Change ◽  
Normal Tissues ◽  
Differential Coexpression ◽  
Cancer Pathogenesis ◽  
Differential Gene

Differential gene analyses on gastric cancer usually focus on expression change of single genes between tumor and adjacent normal tissues. However, besides changes on single genes, there are also coexpression and expression network module changes during the development of gastric cancer. In this study, we proposed a pipeline to investigate various levels of changes between gastric cancer and adjacent normal tissues, which were used to repurpose potential drugs for treating gastric cancer. Specifically, we performed a series of analyses on 242 gastric cancer samples (33-normal, 209-cancer) downloaded from the cancer genome atlas (TCGA), including data quality control, differential gene analysis, gene coexpression network analysis, module function enrichment analysis, differential coexpression analysis, differential pathway analysis, and screening of potential therapeutic drugs. In the end, we discovered some genes and pathways that are significantly different between cancer and adjacent normal tissues (such as the interleukin-4 and interleukin-13 signaling pathway) and screened perturbed genes by 2703 drugs that have a high overlap with the identified differentially expressed genes. Our pipeline might be useful for understanding cancer pathogenesis as well as gastric cancer treatment.

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