Self-nanoemulsifying drug delivery system (SNEDDS) of Amomum compactum essential oil: Design, formulation, and characterization

Considering the therapeutic effects of formulations with violate essential oils, development of an available drug delivery system is of great interest, especially assuming the fact that using essential oils as antimicrobial agents is a rather expanded in antimicrobial therapy nowadays. In this work, chitosan microparticles with encapsulated thyme essential oil were prepared by the emulsion cross-linking method. The effect of thyme oil and glutaraldehyde initial concentrations on particle size, morphology, and particle size distribution was investigated. In addition, the influence of these parameters on the encapsulation of thyme oil in chitosan microparticles, concerning thyme oil loadings and encapsulation efficiency was also tested. The particles showed a spherical shape with an average diameter from 4.71?1.42 to 13.65?4.34 m, depending on the concentration of the essential oil and glutaraldehyde that were used. The diameter of microparticles appeared to increase with increasing the thyme essential oil concentration, and decreased with the increase of glutaraldehyde concentration. It was shown that the concentration of glutaraldehyde did not affect the degree of encapsulation, but the increase in the initial concentration of thyme oil increased the degree of encapsulation of this essential oil in chitosan microparticles. All particles containing thyme essential oil, as well as essential oil of thyme itself showed significant antimicrobial activity against Staphylococcus aureus ATCC 25923, Esherichia coli ATCC 25922, Candida albicans ATCC 24433, Enterococcus faecalis ATCC 25929. This study showed a great potential of the use of thyme essential oil as an antimicrobial agent, especially when encapsulated in a drug delivery system with controlled release of the active antimicrobial component.

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Therapeutic potential of Cymbopogon schoenanthus (L.) developed into nanoparticle technology

Pharmacy Education ◽

10.46542/pe.2021.212.210214 ◽

2021 ◽

pp. 210-214

Author(s):

Lutfi Chabib ◽

Adnan Muhammad Uno J Hidayat ◽

A.M. Bagas Trianloka ◽

Muhammad Iqbal Pangestu ◽

Arman Suryani ◽

...

Keyword(s):

Drug Delivery ◽

Essential Oil ◽

Drug Delivery System ◽

Delivery System ◽

Therapeutic Potential ◽

Potential Effectiveness ◽

Comprehensive Information ◽

Anti Inflammatory ◽

Cymbopogon Schoenanthus

Introduction: One of plants that may have therapeutic potential is the Cymbopogon schoenanthus (L.) Spreng, also known as camel grass. Aim: This review aims to investigate and gather comprehensive information about camel grass plants and their potential to be developed into a nanotechnology drug delivery system. Methods: This review examined a variety of online literature. Results: It was found that camel grass contains essential oil such as piperitone. Piperitone is efficacious as an antioxidant, antimicrobial and anti-inflammatory, in addition to other properties . The development of camel grass essential oil into lipid-based nanotechnology preparations can improve its bioavailability, solubility, and stability, thereby improving its potential effectiveness.

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Biological investigation of a supersaturated self-nanoemulsifying drug delivery system of Piper cubeba essential oil

RSC Advances ◽

10.1039/c5ra22900f ◽

2015 ◽

Vol 5 (127) ◽

pp. 105206-105217 ◽

Cited By ~ 9

Author(s):

Faiyaz Shakeel ◽

Gamal A. Shazly ◽

Mohammad Raish ◽

Ajaz Ahmad ◽

Mohd Abul Kalam ◽

...

Keyword(s):

Drug Delivery ◽

Essential Oil ◽

Drug Delivery System ◽

Delivery System ◽

Inflammatory Activity ◽

Biological Investigation ◽

Anti Inflammatory

In this work, the mechanism of Piper cubeba essential oil anti-inflammatory activity alone and as a supersaturated self-nanoemulsifying drug delivery system (S-SNEDDS) was evaluated.

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Synthesis, Characterization and Cytoxicity Evaluation of Syzygium Aromaticum L. Bud (Clove) Essential Oil Nanoemulsion

10.21203/rs.3.rs-952488/v1 ◽

2021 ◽

Author(s):

Atena Vafaei Malek Abadi ◽

Ehsan Karimi ◽

Ehsan Oskoueian ◽

Ghasem Rahimi Kalateh Shah Mohammad ◽

Negin Shafaei

Keyword(s):

Drug Delivery ◽

Lipid Peroxidation ◽

Colon Cancer ◽

Essential Oil ◽

Drug Delivery System ◽

Delivery System ◽

Cytotoxic Activities ◽

Syzygium Aromaticum ◽

Antioxidant Genes ◽

Ht 29

Abstract Background: The present study performs to improve the medicinal properties of Syzygium Aromaticum L by processing S. Aromaticum L. Bud essential oil (SABE) to the Nano Emulsion drug delivery system (SABE-NE) and investigate its anti-tumor and apoptotic impacts on human HT-29 colon cancer cells and to evaluate the toxicity of SABE-NE. Applying the ultra-sonication method and characterization by DLS and FESEM analysis facilitates the nano-emulsification procedure. Then both human cancer (HT-29) and normal (HFF) cell lines were evaluated based on the SABE-NE apoptotic and cytotoxic impacts. In an in-vitro section, flow cytometry method, Cas3 gene profile, AO/PI cell staining, and MTT assays apply to analyze the apoptotic and cytotoxic activities, and in further analysis measuring liver lipid peroxidation and antioxidant genes expression (SOD, CAT, and GPx) investigate in mice organs alterations. Result: As a result, produced 131.2 nm SABE-NE induces apoptosis response and cellular death (Cas3 up-regulation and enhanced SubG1 peaks), and subsequently, the HT-29 cells' viability can reduce significantly, while HFF cells indicate confined cytotoxic impacts. Moreover, in-vivo test results on mice liver demonstrate the cytoprotective properties of SABE-NE (reduced lipid peroxidation and increased antioxidant enzymes gene expression and non-detectable cytotoxic impacts).Conclusion: We produced a novel nature nanoemulsion drug delivery system called SABE-NE, which is cell-specific apoptotic inducer and thus can be utilized as an efficient anti-cancer compound for human colon cancer treatment. However, to verify and approve its cell-specific anti-tumor activity, further supplementary studies are required.

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Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2009.08.035 ◽

2010 ◽

Vol 383 (1-2) ◽

pp. 170-177 ◽

Cited By ~ 138

Author(s):

Yi Zhao ◽

Changguang Wang ◽

Albert H.L. Chow ◽

Ke Ren ◽

Tao Gong ◽

...

Keyword(s):

Drug Delivery ◽

Essential Oil ◽

Drug Delivery System ◽

Delivery System ◽

Oral Delivery ◽

Oil Formulation

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Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

INDONESIAN JOURNAL OF PHARMACY ◽

10.22146/ijp.584 ◽

2020 ◽

pp. 238-243

Author(s):

Retno Sunarminingsih Sudibyo ◽

Lukman Mahdi ◽

Ronny Martien

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Essential Oil ◽

Zeta Potential ◽

Drug Delivery System ◽

Droplet Size ◽

Delivery System ◽

Stability Study ◽

Freeze Thaw ◽

Lattice Design

Essential oil of Curcuma mangga Val. has been reported to have cytotoxic effect against cancer cell lines. But this oil is unstable in dispensing so that a self nano-emulsifying drug delivery system (SNEDDS) of the oil was conducted to solve the problem and improve its potency. In the study, optimization, verification, characterization, and stability test of the SNEDDS formula were carried out respectively by simplex lattice design (SLD) on Design Expert ver. 10 software, droplet size and Zeta potential determinations using particle size analyzer (PSA) instrument, as well as heating-cooling and freeze-thaw methods. The best SNEDDS formula resulted was Miglyol : Tween 80 : PEG 400 = 16.034% : 68.380% : 15.586%; with transmittance of 84.47 + 1.05%, droplet size of 15.75 nm, zeta potential of -8.54 mV, polydispersity index (PDI) of 0.188, emulsifying time of 49.67 + 1.7 seconds in distilled water, 24.33 + 4.19 seconds in artificial gastric fluid and 21.33 + 2.87 seconds in artificial intestine fluid. After a freeze-thaw test there was no change on the emulsion’s clarity, color, smell, as well as no separation, which means that the formula was stable thermodynamically. The optimum SNEDDS formula resulted has small particle size, better emulsifying time in artificial gastric and intestine fluids, as well as better thermodynamic stability, which in turn will improve the cytotoxic activity of the Curcuma mangga Val. rhizome oil toward cancer cells.

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