scholarly journals Major problem of today’s generations

2018 ◽  
Vol 8 (2) ◽  
pp. 10
Author(s):  
Anurag Shukla ◽  
Shashi Pratap Singh ◽  
Noopur Srivastava ◽  
Kanchan Lata Gupta
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Clinical Studies ◽  
Effective Treatments

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. The search for an extended understanding of the causes of depression, and for the development of additional effective treatments is highly significant. Clinical and pre-clinical studies suggest stress is a key mediator in the pathophysiology of depression.

Nosological validity of dysthymia. Part I: historical, epidemiological and clinical data

1998 ◽  
Vol 13 (4) ◽  
pp. 173-180 ◽  
Author(s):  
L Waintraub ◽  
JD Guelfi
Keyword(s):  
Major Depression ◽  
Clinical Data ◽  
Clinical Studies ◽  
Clinical Pattern ◽  
The World ◽  
Diagnostic Label ◽  
Methodological Difficulties

SummaryDysthymia is the last diagnostic label introduced after a series of precursors to describe a disorder whose nosological status has long been dubious. The results of published epidemiological, as well as clinical studies about its presentation, course and outcome partly support the validity of this construct — although their interpretation is limited by methodological difficulties: same prevalence in many locations in the world, always lower than that of major depression, somewhat specific clinical pattern, course and outcome.

scholarly journals Kleptomania, mood disorder and lithium

1992 ◽  
Vol 50 (4) ◽  
pp. 543-546 ◽  
Author(s):  
Fábio Lopes Rocha ◽  
Maria Elizabete Guimarães Rocha
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Pharmacological Treatment ◽  
Lithium Therapy ◽  
Bipolar Mood Disorder

Kleptomania has been found in association with major depression in a fairly large number of reports in recent years. We describe a patient with concurrent DSM-III-R Bipolar Mood Disorder and Kleptomania, whose symptoms remitted completely, apparently in response to lithium therapy, which raised the possibility that pharmacological treatment may benefit kleptomania. Further studies are needed to establish the possible relationship between kleptomania, mood disorders and lithium therapy.

Time course for memory dysfunction in early-life and late-life major depression: A longitudinal study from the Juntendo university mood disorder project

2013 ◽  
Vol 151 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Hitoshi Maeshima ◽  
Hajime Baba ◽  
Yoshiyuki Nakano ◽  
Emi Satomura ◽  
Yuki Namekawa ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Major Depression ◽  
Mood Disorder ◽  
Early Life ◽  
Time Course ◽  
Late Life ◽  
Memory Dysfunction

Emotion socialization in mothers with mood disorders: Affective modeling and recollected responses to childhood emotion

2020 ◽  
pp. 1-14
Author(s):  
Madelyn H. Labella ◽  
Sarah K. Ruiz ◽  
Susan J. Harris ◽  
Bonnie Klimes-Dougan
Keyword(s):  
Bipolar Disorder ◽  
Early Childhood ◽  
Young Adults ◽  
Young Adult ◽  
Major Depression ◽  
Mood Disorder ◽  
Multilevel Models ◽  
Emotion Socialization ◽  
Maternal Responses ◽  
Affective Modeling

Abstract Growing evidence suggests that emotion socialization may be disrupted by maternal depression. However, little is known about emotion-related parenting by mothers with bipolar disorder or whether affective modeling in early childhood is linked to young adults’ recollections of emotion socialization practices. The current study investigates emotion socialization by mothers with histories of major depression, bipolar disorder, or no mood disorder. Affective modeling was coded from parent–child interactions in early childhood and maternal responses to negative emotions were recollected by young adult offspring (n = 131, 59.5% female, M age = 22.16, SD = 2.58). Multilevel models revealed that maternal bipolar disorder was associated with more neglecting, punishing, and magnifying responses to children's emotions, whereas maternal major depression was associated with more magnifying responses; links between maternal diagnosis and magnifying responses were robust to covariates. Young adult recollections of maternal responses to emotion were predicted by affective modeling in early childhood, providing preliminary validity evidence for the Emotions as a Child Scale. Findings provide novel evidence that major depression and bipolar disorder are associated with altered emotion socialization and that maternal affective modeling in early childhood prospectively predicts young adults’ recollections of emotion socialization in families with and without mood disorder.

scholarly journals Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lucia Carboni ◽  
Dennis J. McCarthy ◽  
Bruno Delafont ◽  
Michele Filosi ◽  
Elena Ivanchenko ◽  
...  
Keyword(s):  
Major Depression ◽  
Clinical Studies

Dysthymia and Major Depression: Distinct Conditions or Different Stages Along a One-Dimensional Continuum?

2003 ◽  
Vol 17 (4) ◽  
pp. 335-346 ◽  
Author(s):  
Patrick Pössel
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Belief Systems ◽  
Core Beliefs ◽  
One Dimensional ◽  
Negative Beliefs ◽  
Depressed Group ◽  
Positive Core ◽  
Data Point

Until recently researchers have discussed whether dysthymia and major depression represent distinct conditions or rather different stages along a one-dimensional continuum. This study addresses this question by examining the belief systems of normal, dysthymic, and depressed participants. We explored participants’ beliefs and differentiated between positive and negative as well as between core and peripheral beliefs. Normal participants showed fewer negative beliefs and negative peripheral beliefs than the dysthymic group, whereas normal participants had more positive beliefs and positive core beliefs as well as fewer negative core beliefs than the depressed group. The hypothesized one-dimensional continuum could not be demonstrated for the belief systems. Instead, the data point to the conclusion that our idea of a one-dimensional continuum reaching from normal to dysthymic to depressed was too simple. Apparently, the differences in the belief systems reported here are related to the chronic character and severity of the mood disorder.

scholarly journals Time to recovery of an inception cohort with hitherto untreated unipolar major depressive episodes

2000 ◽  
Vol 177 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Toshiaki A. Furukawa ◽  
Toshinori Kitamura ◽  
Kiyohisa Takahashi
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Tertiary Care ◽  
Inception Cohort ◽  
Major Depressive ◽  
Follow Up Study ◽  
History Of ◽  
Major Depressive Episodes ◽  
Depressive Episodes

BackgroundGeneralisability of existing studies on the naturalistic history of major depression is undermined by overrepresentation of in-patients and tertiary care academic centres, inclusion of patients already on treatment and/or incomplete follow-up.AimsTo report the time to recovery of an inception cohort of unipolar major depressive episodes.MethodA multi-centre prospective follow-up study of patients with a mood disorder, who had been selected to be representative of the untreated first-visit patients at 23 psychiatric settings from all over Japan.ResultsThe median time to recovery of the index episode after treatment commencement was 3 months (95% CI 2.5–3.6): 26% of the cohort reached asymptomatic or minimally symptomatic status by I month, 63% by 3 months, 85% by 12 months and 88% by 24 months.ConclusionsOur estimate of the episode length was 25–50% shorter than estimates reported in the literature.

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