Differences in body circumferences, skin-fold thicknesses and lipid profiles among HIV-infected African children on and not on stavudine

Sthaulya is included under eight undesirable conditions (Ashtau Nindita), Shleshma Nanatmaa, Samtarpana Nimittaja, Atinindita, Ati Brihmana Nimittaja, and Bahu Dosha Janita Vikara. Moreover, Sushruta has emphasized on metabolic disturbances (Dhatva agnimandya) in the etiopathogenesis of Sthaulya. The World Health Organization (WHO) defines BMI between 25 -29.9 is overweight and BMI greater than 30 is obesity. The present study is a clinical study to evaluate the efficacy of Vidangadi Compound (VC) on Obesity and type II diabetes. Diagnosed patients were selected from Ayurveda Teaching Hospital at Borella from the period of January 2015 to May 2016. Thirty patients (30) who had BMI between 25 to 45 and fasting blood glucose <200 mg/dl were included in the study. Subjective assessment criteria were the sympoms of obesity with proper grading whereas objective criteria were BMI, body circumferences, skin-fold thickness, Lipid profile and FBS. Data were analyzed by using SPSS statistical software. In this study, Vidangadi Compound (VC) in the form of pill was given 1 g (each pill 500mg) at 8.00 A.M & 6.00 P.M before meal for eight weeks with 5 ml bee honey. VC improved Sphik Chalata, Anga Gaurava, Anga daurgandaya, Ati- kshudha, Daurbalya, Sewedadikya, Uthsha hani, Gathrasada, Udara Chalata, Sthana Chalata, body circumferences, BMI, Skin Fold Thickness, Fasting Blood Sugar (from 96.30Â±1.63 to 92.61Â±1.58), Triglyceride (from126.94 Â± 8.28 to 115.84 Â± 9.02) and HDL(from 46.88 Â±1.98 to52.13Â±1.01) in statistically highly significant manner (p<0.001). VC is composed of Katu (66.6%), Tikta (50% ) and Kashaya rasa (83.33%); Laghu (33.33%), Ruksha (33.3%), Thiksna (16.66%), Sukshma (16.6%) and yogavahi guna ( 16.6%); Ushana virya (50%) and Katu vipaka (83.3%). Collectively, these properties of VC are responsible in improving subjective as well as objective parameters of sthaulya especially Lipid profile and Fasting Blood Sugar significantly.

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Adverse Lipid Profiles in Lupus May Stem From Autoimmunity

Internal Medicine News ◽

10.1016/s1097-8690(05)72244-7 ◽

2005 ◽

Vol 38 (21) ◽

pp. 23 ◽

Cited By ~ 1

Author(s):

COLIN NELSON

Keyword(s):

Lipid Profiles

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No effect of vitamin D supplementation on metabolic parameters but on lipids in patients with type 2 diabetes and chronic kidney disease

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000642 ◽

2020 ◽

pp. 1-10

Author(s):

Jiwoon Kim ◽

Ji Sun Nam ◽

Heejung Kim ◽

Hye Sun Lee ◽

Jung Eun Lee

Keyword(s):

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Vitamin D ◽

Kidney Disease ◽

Vitamin D Supplementation ◽

Lipid Profiles ◽

Metabolic Parameters ◽

Injection Group ◽

Different Doses

Abstract. Background/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n = 33), the oral cholecalciferol 1,000 IU/day group (B, n = 34), or the single 200,000 IU injection group (C, n = 25, equivalent to 2,000 IU/day). 52% of the patients had less than 60 mL/min/1.73m2 of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4 ± 1.2 ng/mL vs. B, 10.7 ± 1.2 ng/mL vs. C, 14.6 ± 1.7 ng/mL; p < 0.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters.

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Cardioprotective Effects of Diet with Different Grains on Lipid Profiles and Antioxidative System in Obesity-Induced Rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000097 ◽

2012 ◽

Vol 82 (2) ◽

pp. 85-93 ◽

Cited By ~ 9

Author(s):

Y. Kim ◽

H. Shin ◽

S. Lee

Keyword(s):

Aortic Wall ◽

Plasma Lipids ◽

Antioxidant Activities ◽

Plasma Lipid ◽

Density Lipoprotein ◽

Thiobarbituric Acid ◽

Lipid Profiles ◽

Dietary Lipids ◽

Male Rats

In the present study, the nutritional quality of four grains including adlay (AD), buckwheat (BW), glutinous barley (GB), and white rice (WR) were evaluated in terms of plasma lipid parameters, gut transit time, and thickness of the aortic wall in rats. The rats were then raised for 4 weeks on the high-fat diet based on the American Institute of Nutrition-93 (AIN-93 G) diets containing 1 % cholesterol and 20 % dietary lipids. Forty male rats were divided into 4 groups and raised for 4 weeks with a diet containing one of the following grains: WR, AD, BW, or WB. The level of thiobarbituric acid-reactive substances (TBARS) in liver was shown to be higher in rats by the order of those fed WR, AD, GB, and BW. This indicates that other grains decreased oxidative stress in vivo more than WR. The superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase levels in the AD, BW, and GB groups were significantly higher than those in the WR group (p < 0.05). Plasma lipid profiles differed significantly according to grain combination, and decreased aortic wall thickness was consistent with the finding of decreased plasma low-density lipoprotein cholesterol (LDL-C) (p < 0.05) and increased high-density lipoprotein (HDL-C) in rats fed AD, BW, and GB (p < 0.001). The antioxidant and hypolipidemic capacities of grains are quite high, especially those of adlay, buckwheat, and glutinous barley. In conclusion, this study has demonstrated that the whole grains had a cardioprotective effect. This effect was related to several mechanisms that corresponded to lowering plasma lipids, decreasing TBARS, and increasing antioxidant activities.

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Variations in the Lipid Profile of Patients with Chronic Renal Failure, Treated with Folic Acid

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.73.3.215 ◽

2003 ◽

Vol 73 (3) ◽

pp. 215-220 ◽

Cited By ~ 1

Author(s):

de Gómez Dumm ◽

Giammona ◽

Touceda

Keyword(s):

Renal Failure ◽

Folic Acid ◽

Chronic Renal Failure ◽

Density Lipoprotein ◽

Plasma Homocysteine ◽

Lipid Profiles ◽

Erythrocyte Membranes ◽

Favorable Effect ◽

High Dose ◽

Acid Therapy

Dyslipidemia and increases in plasma homocysteine usually occur at end-stage renal disease; both are recognized as risk factors for atherosclerosis. Folate administration reduces homocysteine concentration. In this study we determined the effect of a high dose of folic acid (40 mg intravenous injection three times a week) on plasma and red blood cell lipid profiles in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (baseline) and after 21, 42, and 64 days of treatment. Folic acid supplementation decreased plasma homocysteine. Plasma triglyceride levels decreased whereas polyunsaturated fatty acid values increased after 21 days; then they returned to baseline levels at the end of treatment. Total cholesterol and low-density lipoprotein (LDL) cholesterol were higher than those of the baseline during all the study, whereas high-density lipoprotein (HDL) cholesterol was reduced. In erythrocyte membranes, folic acid therapy enhanced cholesterol/phospholipid ratios and the fluorescence anisotropy of diphenyl-hexatriene. We conclude that large doses of folic acid produce a favorable effect, reducing plasma homocysteine levels and protecting patients from atherosclerosis. However, as this therapy induces significant alterations in both plasma and erythrocyte membrane lipid profiles, plasma lipid values should be controlled throughout the treatment of patients with renal failure.

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