scholarly journals Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive lung disease

2015 ◽  
Vol 4 (3) ◽  
pp. 279-286
Author(s):  
Shuji Oh-ishi ◽  
Kenji Nemoto ◽  
Takefumi Saito
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
And Oxidative Stress

scholarly journals Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease

2013 ◽  
Vol 305 (10) ◽  
pp. R1163-R1170 ◽  
Author(s):  
Matthew J. Rossman ◽  
Ryan S. Garten ◽  
H. Jonathan Groot ◽  
Van Reese ◽  
Jia Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Antioxidant Capacity ◽  
Chronic Obstructive ◽  
Muscle Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Skeletal Muscle Fatigue ◽  
Systemic Oxidative Stress ◽  
Skeletal Muscle Dysfunction

Chronic obstructive pulmonary disease (COPD) is associated with systemic oxidative stress and skeletal muscle dysfunction. The purpose of this study was to examine the impact of intravenous ascorbate administration (AO) on biological markers of antioxidant capacity and oxidative stress, and subsequently skeletal muscle function during dynamic, small muscle mass exercise in patients with COPD. Ten patients with spirometric evidence of COPD performed single-leg knee extensor (KE) trials matched for intensity and time (isotime) following intravenous ascorbate (2 g) or saline infusion (PL). Quadriceps fatigue was quantified by changes in force elicited by maximal voluntary contraction (MVC) and magnetic femoral nerve stimulation (Qtw,pot). AO administration significantly increased antioxidant capacity, as measured by the ferric-reducing ability of plasma (PL: 1 ± 0.1 vs. AO: 5 ± 0.2 mM), and significantly reduced malondialdehyde levels (PL: 1.16 ± 0.1 vs. AO: 0.97 ± 0.1 mmol). Additionally, resting blood pressure was significantly reduced (PL: 104 ± 4 vs. AO: 93 ± 6 mmHg) and resting femoral vascular conductance was significantly elevated after AO (PL: 2.4 ± 0.2 vs. AO: 3.6 ± 0.4 ml·min−1·mmHg−1). During isotime exercise, the AO significantly attenuated both the ventilatory and metabolic responses, and patients accumulated significantly less peripheral quadriceps fatigue, as illustrated by less of a fall in MVC (PL: −11 ± 2% vs. AO: −5 ± 1%) and Qtw,pot (PL: −37 ± 1% vs. AO: −30 ± 2%). These data demonstrate a beneficial role of AO administration on skeletal muscle fatigue in patients with COPD and further implicate systemic oxidative stress as a causative factor in the skeletal muscle dysfunction observed in this population.

Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease)

2006 ◽  
Vol 109 (1-2) ◽  
pp. 162-172 ◽  
Author(s):  
Michelle J. Hansen ◽  
Rosa C. Gualano ◽  
Steve Bozinovski ◽  
Ross Vlahos ◽  
Gary P. Anderson
Keyword(s):  
Skeletal Muscle ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Muscle Wasting ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Skeletal Muscle Wasting

Intracellular acid-base and electrolyte metabolism in skeletal muscle of patients with chronic obstructive lung disease and acute respiratory failure

1986 ◽  
Vol 71 (6) ◽  
pp. 703-712 ◽  
Author(s):  
E. Fiaccadori ◽  
S. Del Canale ◽  
U. Arduini ◽  
C. Antonucci ◽  
E. Coffrini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Magnesium Content ◽  
Chronic Obstructive ◽  
Intracellular Acidosis ◽  
Total Acid

1. Quadriceps femoris muscle needle biopsies were performed in 21 patients with chronic obstructive lung disease (COLD) and acute respiratory failure (ARF) and in 21 age-matched healthy control subjects. 2. Muscle samples were analysed to obtain intracellular bicarbonate and pH values from total acid-labile carbon dioxide content. Muscle potassium, magnesium and sodium content were also determined, as well as water compartments. 3. Skeletal muscle of COLD patients with ARF showed intracellular acidosis and reduced potassium and magnesium content. Total muscle water increase was linked to extracellular water increment. 4. It was concluded that in COLD patients with ARF an overall derangement of skeletal muscle metabolism is present.

scholarly journals S51 Klotho is associated with skeletal muscle dysfunction and oxidative stress in COPD

Thorax ◽  
2013 ◽  
Vol 68 (Suppl 3) ◽  
pp. A28-A29
Author(s):  
MS Patel ◽  
AV Donaldson ◽  
SA Natanek ◽  
PLB Bruijnzeel ◽  
NS Hopkinson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
And Oxidative Stress
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