scholarly journals TEffectR: an R package for studying the potential effects of transposable elements on gene expression with linear regression model

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e8192 ◽  
Author(s):  
Gökhan Karakülah ◽  
Nazmiye Arslan ◽  
Cihangir Yandım ◽  
Aslı Suner
Keyword(s):  
Gene Expression ◽  
Linear Regression ◽  
Transposable Elements ◽  
Regression Model ◽  
Rna Sequencing ◽  
Linear Regression Model ◽  
R Package ◽  
Breast Cancer Patients ◽  
Sequencing Data ◽  
Data Set

Introduction Recent studies highlight the crucial regulatory roles of transposable elements (TEs) on proximal gene expression in distinct biological contexts such as disease and development. However, computational tools extracting potential TE –proximal gene expression associations from RNA-sequencing data are still missing. Implementation Herein, we developed a novel R package, using a linear regression model, for studying the potential influence of TE species on proximal gene expression from a given RNA-sequencing data set. Our R package, namely TEffectR, makes use of publicly available RepeatMasker TE and Ensembl gene annotations as well as several functions of other R-packages. It calculates total read counts of TEs from sorted and indexed genome aligned BAM files provided by the user, and determines statistically significant relations between TE expression and the transcription of nearby genes under diverse biological conditions. Availability TEffectR is freely available at https://github.com/karakulahg/TEffectR along with a handy tutorial as exemplified by the analysis of RNA-sequencing data including normal and tumour tissue specimens obtained from breast cancer patients.

Applying Artificial Neural Networks. I. Estimating Nicotine in Tobacco from near Infrared Data

1995 ◽  
Vol 3 (3) ◽  
pp. 133-142 ◽  
Author(s):  
M. Hana ◽  
W.F. McClure ◽  
T.B. Whitaker ◽  
M. White ◽  
D.R. Bahler
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Linear Regression Model ◽  
Near Infrared ◽  
Back Propagation ◽  
Linear Network ◽  
Data Set ◽  
Input Layer ◽  
Propagation Network ◽  
Better Than

Two artificial neural network models were used to estimate the nicotine in tobacco: (i) a back-propagation network and (ii) a linear network. The back-propagation network consisted of an input layer, an output layer and one hidden layer. The linear network consisted of an input layer and an output layer. Both networks used the generalised delta rule for learning. Performances of both networks were compared to the multiple linear regression method MLR of calibration. The nicotine content in tobacco samples was estimated for two different data sets. Data set A contained 110 near infrared (NIR) spectra each consisting of reflected energy at eight wavelengths. Data set B consisted of 200 NIR spectra with each spectrum having 840 spectral data points. The Fast Fourier transformation was applied to data set B in order to compress each spectrum into 13 Fourier coefficients. For data set A, the linear regression model gave better results followed by the back-propagation network which was followed by the linear network. The true performance of the linear regression model was better than the back-propagation and the linear networks by 14.0% and 18.1%, respectively. For data set B, the back-propagation network gave the best result followed by MLR and the linear network. Both the linear network and MLR models gave almost the same results. The true performance of the back-propagation network model was better than the MLR and linear network by 35.14%.

scholarly journals Housing Price Prediction Based on Multiple Linear Regression

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Qingqi Zhang
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Multiple Linear Regression ◽  
Linear Regression Model ◽  
Housing Prices ◽  
Housing Price ◽  
Multiple Linear Regression Model ◽  
Data Set ◽  
Factors Affecting ◽  
Price Prediction

In this paper, the author first analyzes the major factors affecting housing prices with Spearman correlation coefficient, selects significant factors influencing general housing prices, and conducts a combined analysis algorithm. Then, the author establishes a multiple linear regression model for housing price prediction and applies the data set of real estate prices in Boston to test the method. Through the data analysis and test in this paper, it can be summarized that the multiple linear regression model can effectively predict and analyze the housing price to some extent, while the algorithm can still be improved through more advanced machine learning methods.

scholarly journals liureg: A Comprehensive R Package for the Liu Estimation of Linear Regression Model with Collinear Regressors

The R Journal ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 232
Author(s):  
Muhammad Imdadullah ◽  
Muhammad Aslam ◽  
Saima Altaf
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Linear Regression Model ◽  
R Package

scholarly journals OUTRIDER: A statistical method for detecting aberrantly expressed genes in RNA sequencing data

2018 ◽  
Author(s):  
Felix Brechtmann ◽  
Agnė Matusevičiūtė ◽  
Christian Mertes ◽  
Vicente A Yépez ◽  
Žiga Avsec ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Sequencing ◽  
Negative Binomial ◽  
Statistical Significance ◽  
P Value ◽  
Rna Seq ◽  
Sequencing Data ◽  
Data Set ◽  
Aberrant Gene Expression ◽  
Aberrant Gene

AbstractRNA sequencing (RNA-seq) is gaining popularity as a complementary assay to genome sequencing for precisely identifying the molecular causes of rare disorders. A powerful approach is to identify aberrant gene expression levels as potential pathogenic events. However, existing methods for detecting aberrant read counts in RNA-seq data either lack assessments of statistical significance, so that establishing cutoffs is arbitrary, or rely on subjective manual corrections for confounders. Here, we describe OUTRIDER (OUTlier in RNA-seq fInDER), an algorithm developed to address these issues. The algorithm uses an autoencoder to model read count expectations according to the co-variation among genes resulting from technical, environmental, or common genetic variations. Given these expectations, the RNA-seq read counts are assumed to follow a negative binomial distribution with a gene-specific dispersion. Outliers are then identified as read counts that significantly deviate from this distribution. The model is automatically fitted to achieve the best correction of artificially corrupted data. Precision–recall analyses using simulated outlier read counts demonstrated the importance of combining correction for co-variation and significance-based thresholds. OUTRIDER is open source and includes functions for filtering out genes not expressed in a data set, for identifying outlier samples with too many aberrantly expressed genes, and for the P-value-based detection of aberrant gene expression, with false discovery rate adjustment. Overall, OUTRIDER provides a computationally fast and scalable end-to-end solution for identifying aberrantly expressed genes, suitable for use by rare disease diagnostic platforms.

scholarly journals Transcriptome RNA Sequencing Data Set of Gene Expression in Moraxella catarrhalis On- and Off-Phase Variants of the Type III DNA Methyltransferase ModM3

2020 ◽  
Vol 9 (14) ◽  
Author(s):  
Luke V. Blakeway ◽  
Aimee Tan ◽  
Ian R. Peak ◽  
John M. Atack ◽  
Kate L. Seib
Keyword(s):  
Gene Expression ◽  
Rna Sequencing ◽  
Moraxella Catarrhalis ◽  
Dna Methyltransferase ◽  
Global Gene Expression ◽  
Chronic Obstructive ◽  
Sequencing Data ◽  
Data Set ◽  
Obstructive Pulmonary Disease ◽  
Content Type

Moraxella catarrhalis is a leading bacterial cause of otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we announce a transcriptome RNA sequencing data set detailing global gene expression in two M. catarrhalis CCRI-195ME variants with expression of the DNA methyltransferase ModM3 phase varied either on or off.

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