Dosimetric Comparisons of Simulation Techniques for Left-Sided Breast Cancer in the COVID-19 Era: Techniques to Reduce Viral Transmission and Respect the Therapeutic Ratio

Aromatase is one of the key enzymes possibly linked with the perpetuation or even initiation of breast cancer. Modulation of its activity by the new generation inhibitors has resulted in increased responses and improved therapeutic ratio compared with those of parent aromatase inhibitors. More recent trials have shown promising results with regard to improved therapeutic ratio compared with what is seen with presently accepted second-line hormonal approaches. Present data and laboratory research indicate that new aromatase inhibitors have the potential to play an important role as adjuvants, and possibly in the prevention of human breast cancer. It is probable that it may be as adjuvants that their real therapeutic strength in terms of a beneficial impact on survival may be realized. The absence of estrogen agonist activity of new aromatase inhibitors on lipid and bone metabolism calls for more clinical studies having late mortality in breast cancer survivors as the ultimate outcome objective; in this regard, interaction of new aromatase inhibitors with new selective estrogen receptor modulators looks promising. Achievement of these outcomes, and understanding of interactions with other therapies, await the termination of present trials and the start of new initiatives.

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Viral Transmission in Breast Cancer

Breast Cancer ◽

10.1007/978-3-642-85832-1_4 ◽

1973 ◽

pp. 15-27

Author(s):

N. H. Sarkar ◽

D. H. Moore

Keyword(s):

Breast Cancer ◽

Viral Transmission

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Biocompatible Implanted Dielectric Sensors for Breast Cancer Detection

International Journal of Handheld Computing Research ◽

10.4018/ijhcr.2014100101 ◽

2014 ◽

Vol 5 (4) ◽

pp. 1-19

Author(s):

Noah P. Svoboda ◽

Abas Sabouni

Keyword(s):

Breast Cancer ◽

Cancer Detection ◽

Breast Tissue ◽

Early Stage ◽

Experimental Testing ◽

High Sensitivity ◽

Breast Cancer Detection ◽

Simulation Techniques ◽

Lc Circuit

This article describes the development of a method for a biocompatible sensor device for the intent of in-vivo breast tissue dielectric properties measurements. This article focuses on a specific type of sensor that utilizes an LC circuit with an inter-digital capacitor (IDC) with small size and high sensitivity for early stage breast cancer detection. To meet this objective an IDC was optimized in terms of contrast and miniaturized size via simulation techniques. For experimental testing, a scaled-up prototype inter-digital capacitor and spiral square inductor sensor was fabricated, and tested with known media, such as distilled water and glycerol. The results suggest that there is a need for further development, such as fabrication and testing for the biocompatible, miniaturized sensor for breast tissue application.

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An imrt technique to increase therapeutic ratio of breast irradiation in patients with early-stage left breast cancer: limiting second malignancies

Medical Dosimetry ◽

10.1016/j.meddos.2007.10.001 ◽

2008 ◽

Vol 33 (1) ◽

pp. 71-77 ◽

Cited By ~ 20

Author(s):

Raef S. Ahmed ◽

Jennifer F. De Los Santos ◽

John B. Fiveash ◽

Kimberly S. Keene ◽

Richard A. Popple

Keyword(s):

Breast Cancer ◽

Early Stage ◽

Left Breast ◽

Breast Irradiation ◽

Second Malignancies ◽

Therapeutic Ratio

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Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared With Photons

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2015.09.018 ◽

2016 ◽

Vol 95 (1) ◽

pp. 411-421 ◽

Cited By ~ 46

Author(s):

Julie A. Bradley ◽

Roi Dagan ◽

Meng Wei Ho ◽

Michael Rutenberg ◽

Christopher G. Morris ◽

...

Keyword(s):

Breast Cancer ◽

Feasibility Trial ◽

Initial Report ◽

Therapeutic Ratio

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Can Proton Therapy Improve the Therapeutic Ratio in Breast Cancer Patients at Risk for Nodal Disease?

American Journal of Clinical Oncology ◽

10.1097/coc.0b013e318280d614 ◽

2014 ◽

Vol 37 (6) ◽

pp. 568-574 ◽

Cited By ~ 20

Author(s):

Natalie Xu ◽

Meng Wei Ho ◽

Zuofeng Li ◽

Christopher G. Morris ◽

Nancy P. Mendenhall

Keyword(s):

Breast Cancer ◽

At Risk ◽

Cancer Patients ◽

Proton Therapy ◽

Breast Cancer Patients ◽

Nodal Disease ◽

Therapeutic Ratio ◽

Patients At Risk

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Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072332 ◽

1973 ◽

Vol 31 ◽

pp. 378-379

Author(s):

G. Kasnic ◽

S. E. Stewart ◽

C. Urbanski

Keyword(s):

Breast Cancer ◽

Biological Activity ◽

Human Breast Cancer ◽

Osteogenic Sarcoma ◽

Human Tumor ◽

Structural Similarity ◽

Cell Tumor ◽

Human Breast ◽

Human Tumor Cell ◽

Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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Image Analysis of Intramembrane Particles in Freeze-Fractured Biomembranes Using Computer Simulation Techniques

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100114694 ◽

1975 ◽

Vol 33 ◽

pp. 214-215

Author(s):

D.J. Benefiel ◽

R.S. Weinstein

Keyword(s):

Membrane Proteins ◽

Freeze Fracture ◽

Integral Membrane Proteins ◽

Systematic Evaluation ◽

Intramembrane Particles ◽

Modeling Methods ◽

Simulation Techniques ◽

Freeze Fracture Electron Microscopy ◽

Fracture Electron ◽

Computer Simulation Techniques

Intramembrane particles (IMP or MAP) are components of most biomembranes. They are visualized by freeze-fracture electron microscopy, and they probably represent replicas of integral membrane proteins. The presence of MAP in biomembranes has been extensively investigated but their detailed ultrastructure has been largely ignored. In this study, we have attempted to lay groundwork for a systematic evaluation of MAP ultrastructure. Using mathematical modeling methods, we have simulated the electron optical appearances of idealized globular proteins as they might be expected to appear in replicas under defined conditions. By comparing these images with the apearances of MAPs in replicas, we have attempted to evaluate dimensional and shape distortions that may be introduced by the freeze-fracture technique and further to deduce the actual shapes of integral membrane proteins from their freezefracture images.

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